Here's a list of John C. Reilly's co-stars in chronological order: Tom Cruise, Leonardo DiCaprio, Sean Penn, Daniel Day-Lewis, Cate Blanchett. Then in 2006, Reilly made the boldest move in his career—he shot Talledega Nights and overnight his call sheet changed to list Will Farrell, Molly Shannon, Seann William Scott, Jonah Hill, Rob Corddry and Ed Helms. (Eclectic? Well, he is a Gemini.) For five years, Reilly's been so successful in comedies that his "serious" career has been practically forgotten, even his Oscar nomination for sadly shuffle-stepping in the shoes of Chicago's sucker husband. But his newest film Terri lets him merge his two interests to play the Assistant Principal and guidance counselor to a troubled teen. Boxoffice sat down with Reilly to hear how he explains—and fights for—his unusual career.