| 1 | How the Grinch Stole Christmas (2000) (Universal) | $441,930,000 | $93,610,000 | $31,203,000 | Nov 17, 2000 |
| 2 | Cast Away (Fox) | $397,045,000 | $49,088,000 | $16,363,000 | Dec 22, 2000 |
| 3 | Mission: Impossible II (Paramount) | $366,076,000 | $98,306,000 | $32,769,000 | May 24, 2000 |
| 4 | Gladiator (2000) (DreamWorks) | $318,995,000 | $59,173,000 | $19,724,000 | May 05, 2000 |
| 5 | What Women Want (2000) (Paramount) | $310,678,000 | $57,126,000 | $19,042,000 | Dec 15, 2000 |
| 6 | The Perfect Storm (Warner Bros.) | $310,349,000 | $70,233,000 | $23,411,000 | Jun 30, 2000 |
| 7 | Meet the Parents (Universal) | $282,524,000 | $48,642,000 | $16,214,000 | Oct 06, 2000 |
| 8 | X-Men (Fox) | $267,321,000 | $92,572,000 | $30,857,000 | Jul 14, 2000 |
| 9 | Scary Movie (Miramax / Dimension) | $266,846,000 | $71,966,000 | $23,989,000 | Jul 07, 2000 |
| 10 | What Lies Beneath (DreamWorks) | $264,196,000 | $50,479,000 | $16,826,000 | Jul 21, 2000 |
| 11 | Dinosaur (Disney) | $234,096,000 | $66,032,000 | $22,011,000 | May 19, 2000 |
| 12 | Crouching Tiger, Hidden Dragon (Sony Pictures Classics) | $217,662,000 | $1,125,000 | $375,000 | Dec 08, 2000 |
| 13 | Erin Brockovich (Universal) | $213,443,000 | $47,820,000 | $15,940,000 | Mar 17, 2000 |
| 14 | Charlie's Angels (2000) (Sony / Columbia) | $212,949,000 | $68,197,000 | $22,732,000 | Nov 03, 2000 |
| 15 | Traffic (USA Films) | $210,928,000 | $26,373,000 | $8,791,000 | Dec 27, 2000 |
| 16 | Nutty Professor II: The Klumps (Universal) | $209,557,000 | $72,257,000 | $24,086,000 | Jul 28, 2000 |
| 17 | Big Momma's House (Fox) | $199,785,000 | $43,607,000 | $14,536,000 | Jun 02, 2000 |
| 18 | Remember the Titans (Disney) | $196,547,000 | $35,528,000 | $11,843,000 | Sep 29, 2000 |
| 19 | The Patriot (Sony / Columbia) | $192,599,000 | $38,092,000 | $12,697,000 | Jun 28, 2000 |
| 20 | Chicken Run (DreamWorks) | $181,559,000 | $29,751,000 | $9,917,000 | Jun 21, 2000 |
| 21 | Miss Congeniality (Warner Bros.) | $181,513,000 | $23,544,000 | $7,848,000 | Dec 22, 2000 |
| 22 | Gone in 60 Seconds (Disney) | $172,745,000 | $43,056,000 | $14,352,000 | Jun 09, 2000 |
| 23 | Unbreakable (Disney) | $161,466,000 | $51,548,000 | $17,183,000 | Nov 22, 2000 |
| 24 | Me, Myself & Irene (Fox) | $153,919,000 | $41,142,000 | $13,714,000 | Jun 23, 2000 |
| 25 | Space Cowboys (Warner Bros.) | $153,740,000 | $30,749,000 | $10,250,000 | Aug 04, 2000 |
| 26 | The Emperor's New Groove (Disney) | $151,764,000 | $16,675,000 | $5,558,000 | Dec 15, 2000 |
| 27 | Scream 3 (Miramax / Dimension) | $151,494,000 | $58,993,000 | $19,664,000 | Feb 04, 2000 |
| 28 | U-571 (Universal) | $131,065,000 | $33,230,000 | $11,077,000 | Apr 21, 2000 |
| 29 | Rugrats in Paris: The Movie (Paramount) | $130,020,000 | $38,608,000 | $12,869,000 | Nov 17, 2000 |
| 30 | The Family Man (Universal) | $128,806,000 | $25,668,000 | $8,556,000 | Dec 22, 2000 |
| 31 | Hollow Man (Sony / Columbia) | $124,415,000 | $44,890,000 | $14,963,000 | Aug 04, 2000 |
| 32 | Chocolat (2000) (Miramax) | $121,525,000 | $268,000 | $89,000 | Dec 15, 2000 |
| 33 | Shaft (2000) (Paramount) | $119,530,000 | $36,903,000 | $12,301,000 | Jun 16, 2000 |
| 34 | Disney's The Kid (Disney) | $118,437,000 | $21,562,000 | $7,187,000 | Jul 07, 2000 |
| 35 | Vertical Limit (Sony / Columbia) | $117,675,000 | $26,355,000 | $8,785,000 | Dec 08, 2000 |
| 36 | Road Trip (DreamWorks) | $116,481,000 | $26,316,000 | $8,772,000 | May 19, 2000 |
| 37 | Bring It On (Universal) | $116,206,000 | $29,504,000 | $9,835,000 | Aug 25, 2000 |
| 38 | 102 Dalmatians (Disney) | $113,791,000 | $33,793,000 | $11,264,000 | Nov 22, 2000 |
| 39 | Rules of Engagement (Paramount) | $104,236,000 | $25,511,000 | $8,504,000 | Apr 07, 2000 |
| 40 | The Cell (New Line) | $104,234,000 | $29,766,000 | $9,922,000 | Aug 18, 2000 |
| 41 | Mission to Mars (Disney) | $103,467,000 | $38,841,000 | $12,947,000 | Mar 10, 2000 |
| 42 | Coyote Ugly (Disney) | $103,302,000 | $29,433,000 | $9,811,000 | Aug 04, 2000 |
| 43 | Fantasia 2000 (Disney) | $103,081,000 | $3,893,000 | $1,298,000 | Jan 01, 2000 |
| 44 | Snow Day (Paramount) | $102,001,000 | $24,356,000 | $8,119,000 | Feb 11, 2000 |
| 45 | Next Friday (New Line) | $97,427,000 | $24,627,000 | $8,209,000 | Jan 12, 2000 |
| 46 | The Whole Nine Yards (Warner Bros.) | $97,314,000 | $23,337,000 | $7,779,000 | Feb 18, 2000 |
| 47 | Shanghai Noon (Disney) | $96,762,000 | $26,523,000 | $8,841,000 | May 26, 2000 |
| 48 | Romeo Must Die (Warner Bros.) | $95,124,000 | $30,615,000 | $10,205,000 | Mar 22, 2000 |
| 49 | Final Destination (New Line) | $90,635,000 | $17,021,000 | $5,674,000 | Mar 17, 2000 |
| 50 | Finding Forrester (Sony / Columbia) | $88,038,000 | $1,192,000 | $397,000 | Dec 22, 2000 |
| 51 | The Road to El Dorado (DreamWorks) | $86,439,000 | $21,832,000 | $7,277,000 | Mar 31, 2000 |
| 52 | Men of Honor (Fox) | $82,964,000 | $22,670,000 | $7,557,000 | Nov 10, 2000 |
| 53 | Dude, Where's My Car? (Fox) | $79,414,000 | $23,530,000 | $7,843,000 | Dec 15, 2000 |
| 54 | The Tigger Movie (Disney) | $77,417,000 | $16,020,000 | $5,340,000 | Feb 11, 2000 |
| 55 | O Brother, Where Art Thou? (Disney) | $77,347,000 | $332,000 | $111,000 | Dec 22, 2000 |
| 56 | Frequency (New Line) | $76,492,000 | $15,338,000 | $5,113,000 | Apr 28, 2000 |
| 57 | The Replacements (Warner Bros.) | $76,029,000 | $18,761,000 | $6,254,000 | Aug 11, 2000 |
| 58 | Pokemon: The Movie 2000 (Warner Bros.) | $74,365,000 | $33,268,000 | $11,089,000 | Jul 21, 2000 |
| 59 | The Beach (Fox) | $67,613,000 | $25,964,000 | $8,655,000 | Feb 11, 2000 |
| 60 | The Exorcist: The Version You've Never Seen (Warner Bros.) | $67,420,000 | $13,894,000 | $4,631,000 | Sep 22, 2000 |
| 61 | Little Nicky (New Line) | $67,068,000 | $27,300,000 | $9,100,000 | Nov 10, 2000 |
| 62 | Pitch Black (USA Films) | $66,687,000 | $19,772,000 | $6,591,000 | Feb 18, 2000 |
| 63 | The Original Kings of Comedy (Paramount) | $64,889,000 | $18,785,000 | $6,262,000 | Aug 18, 2000 |
| 64 | Bedazzled (2000) (Fox) | $64,387,000 | $22,274,000 | $7,425,000 | Oct 20, 2000 |
| 65 | Autumn in New York (MGM) | $64,174,000 | $18,672,000 | $6,224,000 | Aug 11, 2000 |
| 66 | 28 Days (Sony / Columbia) | $63,169,000 | $17,522,000 | $5,841,000 | Apr 14, 2000 |
| 67 | Keeping the Faith (Disney) | $62,960,000 | $13,729,000 | $4,576,000 | Apr 14, 2000 |
| 68 | Bounce (Miramax) | $62,549,000 | $19,414,000 | $6,471,000 | Nov 17, 2000 |
| 69 | Hanging Up (Sony / Columbia) | $61,265,000 | $26,699,000 | $8,900,000 | Feb 18, 2000 |
| 70 | The Flintstones in Viva Rock Vegas (Universal) | $59,937,000 | $17,875,000 | $5,958,000 | Apr 28, 2000 |
| 71 | The Skulls (Universal) | $59,559,000 | $18,756,000 | $6,252,000 | Mar 31, 2000 |
| 72 | The 6th Day (Sony / Columbia) | $58,808,000 | $22,129,000 | $7,376,000 | Nov 17, 2000 |
| 73 | Thirteen Days (New Line) | $58,788,000 | $16,602,000 | $5,534,000 | Dec 25, 2000 |
| 74 | My Dog Skip (Warner Bros.) | $58,010,000 | $97,000 | $32,000 | Jan 14, 2000 |
| 75 | Where the Heart Is (Fox) | $57,394,000 | $14,093,000 | $4,698,000 | Apr 28, 2000 |
| 76 | Pay It Forward (Warner Bros.) | $56,964,000 | $16,368,000 | $5,456,000 | Oct 20, 2000 |
| 77 | Dracula 2000 (Miramax / Dimension) | $56,119,000 | $14,677,000 | $4,892,000 | Dec 22, 2000 |
| 78 | Return to Me (MGM) | $55,610,000 | $13,291,000 | $4,430,000 | Apr 07, 2000 |
| 79 | Proof of Life (Warner Bros.) | $55,399,000 | $17,348,000 | $5,783,000 | Dec 08, 2000 |
| 80 | Almost Famous (DreamWorks) | $55,291,000 | $3,934,000 | $1,311,000 | Sep 15, 2000 |
| 81 | The Legend of Bagger Vance (DreamWorks) | $52,546,000 | $19,572,000 | $6,524,000 | Nov 03, 2000 |
| 82 | Snatch (Sony / Screen Gems) | $51,542,000 | $47,000 | $16,000 | Dec 08, 2000 |
| 83 | The Art of War (Warner Bros.) | $51,338,000 | $17,693,000 | $5,898,000 | Aug 25, 2000 |
| 84 | Bless the Child (Paramount) | $49,931,000 | $15,998,000 | $5,333,000 | Aug 11, 2000 |
| 85 | The Watcher (Universal) | $49,193,000 | $15,402,000 | $5,134,000 | Sep 08, 2000 |
| 86 | Love & Basketball (New Line) | $46,666,000 | $13,832,000 | $4,611,000 | Apr 21, 2000 |
| 87 | High Fidelity (Disney) | $46,374,000 | $10,926,000 | $3,642,000 | Mar 31, 2000 |
| 88 | Book of Shadows: Blair Witch 2 (Artisan) | $44,928,000 | $22,473,000 | $7,491,000 | Oct 27, 2000 |
| 89 | The Adventures of Rocky & Bullwinkle (Universal) | $44,195,000 | $11,580,000 | $3,860,000 | Jun 30, 2000 |
| 90 | Nurse Betty (USA Films) | $42,776,000 | $12,144,000 | $4,048,000 | Sep 08, 2000 |
| 91 | Reindeer Games (Miramax / Dimension) | $39,714,000 | $13,814,000 | $4,605,000 | Feb 25, 2000 |
| 92 | Titan A.E. (Fox) | $38,668,000 | $15,935,000 | $5,312,000 | Jun 16, 2000 |
| 93 | Billy Elliot (Universal Focus) | $37,379,000 | $367,000 | $122,000 | Oct 13, 2000 |
| 94 | Boys and Girls (Miramax / Dimension) | $37,048,000 | $11,911,000 | $3,970,000 | Jun 16, 2000 |
| 95 | Battlefield Earth (Warner Bros.) | $36,490,000 | $19,627,000 | $6,542,000 | May 12, 2000 |
| 96 | Urban Legends: Final Cut (Sony / Columbia) | $36,485,000 | $14,455,000 | $4,818,000 | Sep 22, 2000 |
| 97 | Down to You (Miramax) | $34,108,000 | $12,920,000 | $4,307,000 | Jan 21, 2000 |
| 98 | Wonder Boys (Paramount) | $32,958,000 | $9,872,000 | $3,291,000 | Feb 23, 2000 |
| 99 | Best in Show (Warner Bros.) | $31,806,000 | $703,000 | $234,000 | Sep 29, 2000 |
| 100 | The Ninth Gate (Artisan) | $31,715,000 | $11,255,000 | $3,752,000 | Mar 10, 2000 |
| 101 | Michael Jordan to the Max (IMAX) | $31,696,000 | $983,000 | $328,000 | May 05, 2000 |
| 102 | The Contender (DreamWorks) | $30,374,000 | $9,116,000 | $3,039,000 | Oct 13, 2000 |
| 103 | Red Planet (Warner Bros.) | $29,708,000 | $14,821,000 | $4,940,000 | Nov 10, 2000 |
| 104 | Small Time Crooks (DreamWorks) | $29,344,000 | $6,596,000 | $2,199,000 | May 19, 2000 |
| 105 | Center Stage (Sony / Columbia) | $29,230,000 | $7,825,000 | $2,608,000 | May 12, 2000 |
| 106 | Boiler Room (New Line) | $28,841,000 | $11,425,000 | $3,808,000 | Feb 18, 2000 |
| 107 | Lost Souls (New Line) | $28,577,000 | $13,519,000 | $4,506,000 | Oct 13, 2000 |
| 108 | Eye of the Beholder (Destination) | $28,042,000 | $10,128,000 | $3,376,000 | Jan 28, 2000 |
| 109 | Thomas and the Magic Railroad (Destination) | $27,079,000 | $7,061,000 | $2,354,000 | Jul 26, 2000 |
| 110 | Cirque du Soleil: Journey of Man (Sony Pictures Classics) | $26,558,000 | $85,000 | $28,000 | May 05, 2000 |
| 111 | Loser (Sony / Columbia) | $26,542,000 | $10,211,000 | $3,404,000 | Jul 21, 2000 |
| 112 | All the Pretty Horses (Miramax) | $26,410,000 | $8,260,000 | $2,753,000 | Dec 25, 2000 |
| 113 | Drowning Mona (Destination) | $26,352,000 | $9,861,000 | $3,287,000 | Mar 03, 2000 |
| 114 | Bait (Warner Bros.) | $26,045,000 | $9,322,000 | $3,107,000 | Sep 15, 2000 |
| 115 | Dungeons & Dragons (2000) (New Line) | $25,867,000 | $12,300,000 | $4,100,000 | Dec 08, 2000 |
| 116 | American Psycho (Lionsgate) | $25,612,000 | $8,431,000 | $2,810,000 | Apr 14, 2000 |
| 117 | The Next Best Thing (Paramount) | $25,475,000 | $9,976,000 | $3,325,000 | Mar 03, 2000 |
| 118 | Get Carter (Warner Bros.) | $25,436,000 | $11,281,000 | $3,760,000 | Oct 06, 2000 |
| 119 | Supernova (2000) (MGM) | $24,184,000 | $11,441,000 | $3,814,000 | Jan 14, 2000 |
| 120 | The Ladies Man (Paramount) | $23,140,000 | $9,222,000 | $3,074,000 | Oct 13, 2000 |
| 121 | The Little Vampire (New Line) | $23,066,000 | $9,720,000 | $3,240,000 | Oct 27, 2000 |
| 122 | Dr. T and the Women (Artisan) | $22,286,000 | $8,519,000 | $2,840,000 | Oct 12, 2000 |
| 123 | The Crew (Disney) | $22,132,000 | $6,886,000 | $2,295,000 | Aug 25, 2000 |
| 124 | Highlander: Endgame (Miramax / Dimension) | $21,773,000 | $10,576,000 | $3,525,000 | Sep 01, 2000 |
| 125 | Ready to Rumble (Warner Bros.) | $21,064,000 | $8,935,000 | $2,978,000 | Apr 07, 2000 |
| 126 | Saving Grace (Fine Line) | $20,697,000 | $489,000 | $163,000 | Aug 04, 2000 |
| 127 | The Gift (2000) (Paramount Classics) | $20,408,000 | $20,000 | $7,000 | Dec 22, 2000 |
| 128 | The Legend of Drunken Master (Miramax / Dimension) | $19,638,000 | $6,535,000 | $2,178,000 | Oct 20, 2000 |
| 129 | Cyberworld 3-D (IMAX) | $19,125,000 | $473,000 | $158,000 | Oct 06, 2000 |
| 130 | Here on Earth (Fox) | $17,882,000 | $7,666,000 | $2,555,000 | Mar 15, 2000 |
| 131 | Lucky Numbers (Paramount) | $17,066,000 | $7,710,000 | $2,570,000 | Oct 27, 2000 |
| 132 | Godzilla 2000 (Sony / TriStar) | $17,058,000 | $7,491,000 | $2,497,000 | Aug 18, 2000 |
| 133 | 3 Strikes (MGM) | $16,710,000 | $6,262,000 | $2,087,000 | Mar 03, 2000 |
| 134 | Digimon: The Movie (Fox) | $16,368,000 | $7,194,000 | $2,398,000 | Oct 06, 2000 |
| 135 | You Can Count on Me (Paramount Classics) | $15,607,000 | $201,000 | $67,000 | Nov 10, 2000 |
| 136 | Whatever It Takes (Sony / Columbia) | $14,863,000 | $6,975,000 | $2,325,000 | Mar 24, 2000 |
| 137 | Pollock (Sony Pictures Classics) | $14,612,000 | $75,000 | $25,000 | Dec 15, 2000 |
| 138 | Shadow of the Vampire (Lionsgate) | $14,094,000 | $255,000 | $85,000 | Dec 29, 2000 |
| 139 | Quills (Fox Searchlight) | $12,007,000 | $424,000 | $141,000 | Nov 24, 2000 |
| 140 | Screwed (Universal) | $11,943,000 | $5,677,000 | $1,892,000 | May 12, 2000 |
| 141 | State and Main (Fine Line) | $11,801,000 | $986,000 | $329,000 | Dec 22, 2000 |
| 142 | I Dreamed of Africa (Sony / Columbia) | $11,303,000 | $4,098,000 | $1,366,000 | May 05, 2000 |
| 143 | What Planet Are You From? (Sony / Columbia) | $10,692,000 | $5,113,000 | $1,704,000 | Mar 03, 2000 |
| 144 | Croupier (Shooting Gallery) | $10,539,000 | $108,000 | $36,000 | Apr 21, 2000 |
| 145 | The Way of the Gun (Artisan) | $10,291,000 | $3,655,000 | $1,218,000 | Sep 08, 2000 |
| 146 | Where the Money Is (USA Films) | $9,621,000 | $4,272,000 | $1,424,000 | Apr 14, 2000 |
| 147 | The In Crowd (Warner Bros.) | $8,974,000 | $2,559,000 | $853,000 | Jul 21, 2000 |
| 148 | Black and White (Sony / Columbia) | $8,969,000 | $3,760,000 | $1,253,000 | Apr 07, 2000 |
| 149 | Gossip (Warner Bros.) | $8,681,000 | $3,946,000 | $1,315,000 | Apr 21, 2000 |
| 150 | Woman on Top (Fox Searchlight) | $8,531,000 | $3,413,000 | $1,138,000 | Sep 22, 2000 |
| 151 | The Virgin Suicides (Paramount Classics) | $8,338,000 | $400,000 | $133,000 | Apr 21, 2000 |
| 152 | Duets (Disney) | $8,055,000 | $3,403,000 | $1,134,000 | Sep 15, 2000 |
| 153 | Held Up (Trimark) | $7,997,000 | $3,248,000 | $1,083,000 | May 12, 2000 |
| 154 | The Tao of Steve (Sony Classics) | $7,380,000 | $156,000 | $52,000 | Aug 04, 2000 |
| 155 | Before Night Falls (Fine Line) | $7,209,000 | $145,000 | $48,000 | Dec 22, 2000 |
| 156 | Dancer in the Dark (Fine Line) | $7,112,000 | $156,000 | $52,000 | Sep 22, 2000 |
| 157 | East is East (Miramax) | $7,099,000 | $91,000 | $30,000 | Apr 14, 2000 |
| 158 | Whipped (Destination) | $7,068,000 | $4,639,000 | $1,546,000 | Sep 01, 2000 |
| 159 | Requiem for a Dream (Artisan) | $6,179,000 | $110,000 | $37,000 | Oct 06, 2000 |
| 160 | The Big Blue: Director's Cut (2000) (IDP) | $6,085,000 | $24,000 | $8,000 | Jul 14, 2000 |
| 161 | Malèna (Miramax) | $5,860,000 | $106,000 | $35,000 | Dec 22, 2000 |
| 162 | Price of Glory (New Line) | $5,847,000 | $2,739,000 | $913,000 | Mar 31, 2000 |
| 163 | Ghost Dog: The Way of the Samurai (Artisan) | $5,622,000 | $283,000 | $94,000 | Mar 03, 2000 |
| 164 | The Big Kahuna (Lions Gate) | $5,380,000 | $138,000 | $46,000 | Apr 28, 2000 |
| 165 | Beautiful (Destination) | $5,366,000 | $2,395,000 | $798,000 | Sep 29, 2000 |
| 166 | The House of Mirth (Sony Classics) | $5,173,000 | $83,000 | $28,000 | Dec 22, 2000 |
| 167 | Isn't She Great (Universal) | $5,035,000 | $2,324,000 | $775,000 | Jan 28, 2000 |
