| 1 | How the Grinch Stole Christmas (2000) (Universal) | $434,694,000 | $92,077,000 | $30,692,000 | Nov 17, 2000 |
| 2 | Cast Away (Fox) | $390,543,000 | $48,284,000 | $16,095,000 | Dec 22, 2000 |
| 3 | Mission: Impossible II (Paramount) | $360,081,000 | $96,696,000 | $32,232,000 | May 24, 2000 |
| 4 | Gladiator (2000) (DreamWorks) | $313,771,000 | $58,204,000 | $19,401,000 | May 05, 2000 |
| 5 | What Women Want (2000) (Paramount) | $305,591,000 | $56,191,000 | $18,730,000 | Dec 15, 2000 |
| 6 | The Perfect Storm (Warner Bros.) | $305,267,000 | $69,083,000 | $23,028,000 | Jun 30, 2000 |
| 7 | Meet the Parents (Universal) | $277,897,000 | $47,846,000 | $15,949,000 | Oct 06, 2000 |
| 8 | X-Men (Fox) | $262,944,000 | $91,056,000 | $30,352,000 | Jul 14, 2000 |
| 9 | Scary Movie (Miramax / Dimension) | $262,476,000 | $70,787,000 | $23,596,000 | Jul 07, 2000 |
| 10 | What Lies Beneath (DreamWorks) | $259,869,000 | $49,653,000 | $16,551,000 | Jul 21, 2000 |
| 11 | Dinosaur (Disney) | $230,263,000 | $64,950,000 | $21,650,000 | May 19, 2000 |
| 12 | Crouching Tiger, Hidden Dragon (Sony Pictures Classics) | $214,098,000 | $1,107,000 | $369,000 | Dec 08, 2000 |
| 13 | Erin Brockovich (Universal) | $209,947,000 | $47,037,000 | $15,679,000 | Mar 17, 2000 |
| 14 | Charlie's Angels (2000) (Sony / Columbia) | $209,462,000 | $67,081,000 | $22,360,000 | Nov 03, 2000 |
| 15 | Traffic (USA Films) | $207,474,000 | $25,941,000 | $8,647,000 | Dec 27, 2000 |
| 16 | Nutty Professor II: The Klumps (Universal) | $206,126,000 | $71,073,000 | $23,691,000 | Jul 28, 2000 |
| 17 | Big Momma's House (Fox) | $196,513,000 | $42,893,000 | $14,298,000 | Jun 02, 2000 |
| 18 | Remember the Titans (Disney) | $193,329,000 | $34,946,000 | $11,649,000 | Sep 29, 2000 |
| 19 | The Patriot (Sony / Columbia) | $189,445,000 | $37,468,000 | $12,489,000 | Jun 28, 2000 |
| 20 | Chicken Run (DreamWorks) | $178,586,000 | $29,264,000 | $9,755,000 | Jun 21, 2000 |
| 21 | Miss Congeniality (Warner Bros.) | $178,540,000 | $23,158,000 | $7,719,000 | Dec 22, 2000 |
| 22 | Gone in 60 Seconds (Disney) | $169,916,000 | $42,351,000 | $14,117,000 | Jun 09, 2000 |
| 23 | Unbreakable (Disney) | $158,822,000 | $50,703,000 | $16,901,000 | Nov 22, 2000 |
| 24 | Me, Myself & Irene (Fox) | $151,398,000 | $40,469,000 | $13,490,000 | Jun 23, 2000 |
| 25 | Space Cowboys (Warner Bros.) | $151,222,000 | $30,246,000 | $10,082,000 | Aug 04, 2000 |
| 26 | The Emperor's New Groove (Disney) | $149,279,000 | $16,402,000 | $5,467,000 | Dec 15, 2000 |
| 27 | Scream 3 (Miramax / Dimension) | $149,014,000 | $58,027,000 | $19,342,000 | Feb 04, 2000 |
| 28 | U-571 (Universal) | $128,919,000 | $32,686,000 | $10,895,000 | Apr 21, 2000 |
| 29 | Rugrats in Paris: The Movie (Paramount) | $127,891,000 | $37,976,000 | $12,659,000 | Nov 17, 2000 |
| 30 | The Family Man (Universal) | $126,697,000 | $25,248,000 | $8,416,000 | Dec 22, 2000 |
| 31 | Hollow Man (Sony / Columbia) | $122,378,000 | $44,155,000 | $14,718,000 | Aug 04, 2000 |
| 32 | Chocolat (2000) (Miramax) | $119,535,000 | $263,000 | $88,000 | Dec 15, 2000 |
| 33 | Shaft (2000) (Paramount) | $117,572,000 | $36,299,000 | $12,100,000 | Jun 16, 2000 |
| 34 | Disney's The Kid (Disney) | $116,498,000 | $21,209,000 | $7,070,000 | Jul 07, 2000 |
| 35 | Vertical Limit (Sony / Columbia) | $115,748,000 | $25,923,000 | $8,641,000 | Dec 08, 2000 |
| 36 | Road Trip (DreamWorks) | $114,573,000 | $25,885,000 | $8,628,000 | May 19, 2000 |
| 37 | Bring It On (Universal) | $114,304,000 | $29,021,000 | $9,674,000 | Aug 25, 2000 |
| 38 | 102 Dalmatians (Disney) | $111,928,000 | $33,240,000 | $11,080,000 | Nov 22, 2000 |
| 39 | Rules of Engagement (Paramount) | $102,529,000 | $25,093,000 | $8,364,000 | Apr 07, 2000 |
| 40 | The Cell (New Line) | $102,527,000 | $29,278,000 | $9,759,000 | Aug 18, 2000 |
| 41 | Mission to Mars (Disney) | $101,773,000 | $38,205,000 | $12,735,000 | Mar 10, 2000 |
| 42 | Coyote Ugly (Disney) | $101,611,000 | $28,951,000 | $9,650,000 | Aug 04, 2000 |
| 43 | Fantasia 2000 (Disney) | $101,393,000 | $3,829,000 | $1,276,000 | Jan 01, 2000 |
| 44 | Snow Day (Paramount) | $100,330,000 | $23,957,000 | $7,986,000 | Feb 11, 2000 |
| 45 | Next Friday (New Line) | $95,832,000 | $24,224,000 | $8,075,000 | Jan 12, 2000 |
| 46 | The Whole Nine Yards (Warner Bros.) | $95,720,000 | $22,955,000 | $7,652,000 | Feb 18, 2000 |
| 47 | Shanghai Noon (Disney) | $95,177,000 | $26,089,000 | $8,696,000 | May 26, 2000 |
| 48 | Romeo Must Die (Warner Bros.) | $93,567,000 | $30,113,000 | $10,038,000 | Mar 22, 2000 |
| 49 | Final Destination (New Line) | $89,150,000 | $16,743,000 | $5,581,000 | Mar 17, 2000 |
| 50 | Finding Forrester (Sony / Columbia) | $86,597,000 | $1,172,000 | $391,000 | Dec 22, 2000 |
| 51 | The Road to El Dorado (DreamWorks) | $85,023,000 | $21,474,000 | $7,158,000 | Mar 31, 2000 |
| 52 | Men of Honor (Fox) | $81,605,000 | $22,298,000 | $7,433,000 | Nov 10, 2000 |
| 53 | Dude, Where's My Car? (Fox) | $78,113,000 | $23,145,000 | $7,715,000 | Dec 15, 2000 |
| 54 | The Tigger Movie (Disney) | $76,149,000 | $15,758,000 | $5,253,000 | Feb 11, 2000 |
| 55 | O Brother, Where Art Thou? (Disney) | $76,080,000 | $326,000 | $109,000 | Dec 22, 2000 |
| 56 | Frequency (New Line) | $75,240,000 | $15,087,000 | $5,029,000 | Apr 28, 2000 |
| 57 | The Replacements (Warner Bros.) | $74,784,000 | $18,453,000 | $6,151,000 | Aug 11, 2000 |
| 58 | Pokemon: The Movie 2000 (Warner Bros.) | $73,147,000 | $32,723,000 | $10,908,000 | Jul 21, 2000 |
| 59 | The Beach (Fox) | $66,506,000 | $25,539,000 | $8,513,000 | Feb 11, 2000 |
| 60 | The Exorcist: The Version You've Never Seen (Warner Bros.) | $66,316,000 | $13,667,000 | $4,556,000 | Sep 22, 2000 |
| 61 | Little Nicky (New Line) | $65,970,000 | $26,853,000 | $8,951,000 | Nov 10, 2000 |
| 62 | Pitch Black (USA Films) | $65,595,000 | $19,448,000 | $6,483,000 | Feb 18, 2000 |
| 63 | The Original Kings of Comedy (Paramount) | $63,826,000 | $18,478,000 | $6,159,000 | Aug 18, 2000 |
| 64 | Bedazzled (2000) (Fox) | $63,332,000 | $21,909,000 | $7,303,000 | Oct 20, 2000 |
| 65 | Autumn in New York (MGM) | $63,123,000 | $18,366,000 | $6,122,000 | Aug 11, 2000 |
| 66 | 28 Days (Sony / Columbia) | $62,134,000 | $17,235,000 | $5,745,000 | Apr 14, 2000 |
| 67 | Keeping the Faith (Disney) | $61,929,000 | $13,504,000 | $4,501,000 | Apr 14, 2000 |
| 68 | Bounce (Miramax) | $61,524,000 | $19,096,000 | $6,365,000 | Nov 17, 2000 |
| 69 | Hanging Up (Sony / Columbia) | $60,262,000 | $26,262,000 | $8,754,000 | Feb 18, 2000 |
| 70 | The Flintstones in Viva Rock Vegas (Universal) | $58,956,000 | $17,582,000 | $5,861,000 | Apr 28, 2000 |
| 71 | The Skulls (Universal) | $58,583,000 | $18,449,000 | $6,150,000 | Mar 31, 2000 |
| 72 | The 6th Day (Sony / Columbia) | $57,845,000 | $21,767,000 | $7,256,000 | Nov 17, 2000 |
| 73 | Thirteen Days (New Line) | $57,825,000 | $16,330,000 | $5,443,000 | Dec 25, 2000 |
| 74 | My Dog Skip (Warner Bros.) | $57,060,000 | $95,000 | $32,000 | Jan 14, 2000 |
| 75 | Where the Heart Is (Fox) | $56,454,000 | $13,863,000 | $4,621,000 | Apr 28, 2000 |
| 76 | Pay It Forward (Warner Bros.) | $56,031,000 | $16,100,000 | $5,367,000 | Oct 20, 2000 |
| 77 | Dracula 2000 (Miramax / Dimension) | $55,200,000 | $14,437,000 | $4,812,000 | Dec 22, 2000 |
| 78 | Return to Me (MGM) | $54,699,000 | $13,073,000 | $4,358,000 | Apr 07, 2000 |
| 79 | Proof of Life (Warner Bros.) | $54,491,000 | $17,064,000 | $5,688,000 | Dec 08, 2000 |
| 80 | Almost Famous (DreamWorks) | $54,386,000 | $3,869,000 | $1,290,000 | Sep 15, 2000 |
| 81 | The Legend of Bagger Vance (DreamWorks) | $51,686,000 | $19,251,000 | $6,417,000 | Nov 03, 2000 |
| 82 | Snatch (Sony / Screen Gems) | $50,698,000 | $47,000 | $16,000 | Dec 08, 2000 |
| 83 | The Art of War (Warner Bros.) | $50,498,000 | $17,403,000 | $5,801,000 | Aug 25, 2000 |
| 84 | Bless the Child (Paramount) | $49,114,000 | $15,736,000 | $5,245,000 | Aug 11, 2000 |
| 85 | The Watcher (Universal) | $48,388,000 | $15,150,000 | $5,050,000 | Sep 08, 2000 |
| 86 | Love & Basketball (New Line) | $45,902,000 | $13,606,000 | $4,535,000 | Apr 21, 2000 |
| 87 | High Fidelity (Disney) | $45,614,000 | $10,747,000 | $3,582,000 | Mar 31, 2000 |
| 88 | Book of Shadows: Blair Witch 2 (Artisan) | $44,193,000 | $22,105,000 | $7,368,000 | Oct 27, 2000 |
| 89 | The Adventures of Rocky & Bullwinkle (Universal) | $43,471,000 | $11,391,000 | $3,797,000 | Jun 30, 2000 |
| 90 | Nurse Betty (USA Films) | $42,076,000 | $11,945,000 | $3,982,000 | Sep 08, 2000 |
| 91 | Reindeer Games (Miramax / Dimension) | $39,064,000 | $13,587,000 | $4,529,000 | Feb 25, 2000 |
| 92 | Titan A.E. (Fox) | $38,035,000 | $15,674,000 | $5,225,000 | Jun 16, 2000 |
| 93 | Billy Elliot (Universal Focus) | $36,767,000 | $361,000 | $120,000 | Oct 13, 2000 |
| 94 | Boys and Girls (Miramax / Dimension) | $36,441,000 | $11,716,000 | $3,905,000 | Jun 16, 2000 |
| 95 | Battlefield Earth (Warner Bros.) | $35,892,000 | $19,305,000 | $6,435,000 | May 12, 2000 |
| 96 | Urban Legends: Final Cut (Sony / Columbia) | $35,887,000 | $14,218,000 | $4,739,000 | Sep 22, 2000 |
| 97 | Down to You (Miramax) | $33,549,000 | $12,708,000 | $4,236,000 | Jan 21, 2000 |
| 98 | Wonder Boys (Paramount) | $32,418,000 | $9,710,000 | $3,237,000 | Feb 23, 2000 |
| 99 | Best in Show (Warner Bros.) | $31,285,000 | $691,000 | $230,000 | Sep 29, 2000 |
| 100 | The Ninth Gate (Artisan) | $31,195,000 | $11,070,000 | $3,690,000 | Mar 10, 2000 |
| 101 | Michael Jordan to the Max (IMAX) | $31,177,000 | $966,000 | $322,000 | May 05, 2000 |
| 102 | The Contender (DreamWorks) | $29,876,000 | $8,966,000 | $2,989,000 | Oct 13, 2000 |
| 103 | Red Planet (Warner Bros.) | $29,221,000 | $14,579,000 | $4,860,000 | Nov 10, 2000 |
| 104 | Small Time Crooks (DreamWorks) | $28,864,000 | $6,488,000 | $2,163,000 | May 19, 2000 |
| 105 | Center Stage (Sony / Columbia) | $28,752,000 | $7,697,000 | $2,566,000 | May 12, 2000 |
| 106 | Boiler Room (New Line) | $28,368,000 | $11,238,000 | $3,746,000 | Feb 18, 2000 |
| 107 | Lost Souls (New Line) | $28,109,000 | $13,297,000 | $4,432,000 | Oct 13, 2000 |
| 108 | Eye of the Beholder (Destination) | $27,583,000 | $9,962,000 | $3,321,000 | Jan 28, 2000 |
| 109 | Thomas and the Magic Railroad (Destination) | $26,635,000 | $6,945,000 | $2,315,000 | Jul 26, 2000 |
| 110 | Cirque du Soleil: Journey of Man (Sony Pictures Classics) | $26,123,000 | $83,000 | $28,000 | May 05, 2000 |
| 111 | Loser (Sony / Columbia) | $26,108,000 | $10,044,000 | $3,348,000 | Jul 21, 2000 |
| 112 | All the Pretty Horses (Miramax) | $25,977,000 | $8,125,000 | $2,708,000 | Dec 25, 2000 |
| 113 | Drowning Mona (Destination) | $25,921,000 | $9,699,000 | $3,233,000 | Mar 03, 2000 |
| 114 | Bait (Warner Bros.) | $25,619,000 | $9,170,000 | $3,057,000 | Sep 15, 2000 |
| 115 | Dungeons & Dragons (2000) (New Line) | $25,443,000 | $12,098,000 | $4,033,000 | Dec 08, 2000 |
| 116 | American Psycho (Lionsgate) | $25,192,000 | $8,293,000 | $2,764,000 | Apr 14, 2000 |
| 117 | The Next Best Thing (Paramount) | $25,058,000 | $9,813,000 | $3,271,000 | Mar 03, 2000 |
| 118 | Get Carter (Warner Bros.) | $25,019,000 | $11,096,000 | $3,699,000 | Oct 06, 2000 |
| 119 | Supernova (MGM) | $23,788,000 | $11,253,000 | $3,751,000 | Jan 14, 2000 |
| 120 | The Ladies Man (Paramount) | $22,761,000 | $9,071,000 | $3,024,000 | Oct 13, 2000 |
| 121 | The Little Vampire (New Line) | $22,688,000 | $9,561,000 | $3,187,000 | Oct 27, 2000 |
| 122 | Dr. T and the Women (Artisan) | $21,922,000 | $8,380,000 | $2,793,000 | Oct 12, 2000 |
| 123 | The Crew (Disney) | $21,770,000 | $6,773,000 | $2,258,000 | Aug 25, 2000 |
| 124 | Highlander: Endgame (Miramax / Dimension) | $21,416,000 | $10,403,000 | $3,468,000 | Sep 01, 2000 |
| 125 | Ready to Rumble (Warner Bros.) | $20,719,000 | $8,789,000 | $2,930,000 | Apr 07, 2000 |
| 126 | Saving Grace (Fine Line) | $20,358,000 | $481,000 | $160,000 | Aug 04, 2000 |
| 127 | The Gift (2000) (Paramount Classics) | $20,074,000 | $20,000 | $7,000 | Dec 22, 2000 |
| 128 | The Legend of Drunken Master (Miramax / Dimension) | $19,317,000 | $6,428,000 | $2,143,000 | Oct 20, 2000 |
| 129 | Cyberworld 3-D (IMAX) | $18,811,000 | $465,000 | $155,000 | Oct 06, 2000 |
| 130 | Here on Earth (Fox) | $17,589,000 | $7,540,000 | $2,513,000 | Mar 15, 2000 |
| 131 | Lucky Numbers (Paramount) | $16,787,000 | $7,583,000 | $2,528,000 | Oct 27, 2000 |
| 132 | Godzilla 2000 (Sony / TriStar) | $16,779,000 | $7,368,000 | $2,456,000 | Aug 18, 2000 |
| 133 | 3 Strikes (MGM) | $16,436,000 | $6,159,000 | $2,053,000 | Mar 03, 2000 |
| 134 | Digimon: The Movie (Fox) | $16,100,000 | $7,076,000 | $2,359,000 | Oct 06, 2000 |
| 135 | You Can Count on Me (Paramount Classics) | $15,351,000 | $198,000 | $66,000 | Nov 10, 2000 |
| 136 | Whatever It Takes (Sony / Columbia) | $14,620,000 | $6,861,000 | $2,287,000 | Mar 24, 2000 |
| 137 | Pollock (Sony Pictures Classics) | $14,373,000 | $74,000 | $25,000 | Dec 15, 2000 |
| 138 | Shadow of the Vampire (Lionsgate) | $13,863,000 | $251,000 | $84,000 | Dec 29, 2000 |
| 139 | Quills (Fox Searchlight) | $11,811,000 | $417,000 | $139,000 | Nov 24, 2000 |
| 140 | Screwed (Universal) | $11,747,000 | $5,584,000 | $1,861,000 | May 12, 2000 |
| 141 | State and Main (Fine Line) | $11,608,000 | $970,000 | $323,000 | Dec 22, 2000 |
| 142 | I Dreamed of Africa (Sony / Columbia) | $11,118,000 | $4,031,000 | $1,344,000 | May 05, 2000 |
| 143 | What Planet Are You From? (Sony / Columbia) | $10,517,000 | $5,029,000 | $1,676,000 | Mar 03, 2000 |
| 144 | Croupier (Shooting Gallery) | $10,367,000 | $106,000 | $35,000 | Apr 21, 2000 |
| 145 | The Way of the Gun (Artisan) | $10,123,000 | $3,596,000 | $1,199,000 | Sep 08, 2000 |
| 146 | Where the Money Is (USA Films) | $9,464,000 | $4,202,000 | $1,401,000 | Apr 14, 2000 |
| 147 | The In Crowd (Warner Bros.) | $8,827,000 | $2,517,000 | $839,000 | Jul 21, 2000 |
| 148 | Black and White (Sony / Columbia) | $8,822,000 | $3,699,000 | $1,233,000 | Apr 07, 2000 |
| 149 | Gossip (Warner Bros.) | $8,539,000 | $3,881,000 | $1,294,000 | Apr 21, 2000 |
| 150 | Woman on Top (Fox Searchlight) | $8,392,000 | $3,357,000 | $1,119,000 | Sep 22, 2000 |
| 151 | The Virgin Suicides (Paramount Classics) | $8,201,000 | $393,000 | $131,000 | Apr 21, 2000 |
| 152 | Duets (Disney) | $7,923,000 | $3,348,000 | $1,116,000 | Sep 15, 2000 |
| 153 | Held Up (Trimark) | $7,866,000 | $3,194,000 | $1,065,000 | May 12, 2000 |
| 154 | The Tao of Steve (Sony Classics) | $7,259,000 | $153,000 | $51,000 | Aug 04, 2000 |
| 155 | Before Night Falls (Fine Line) | $7,091,000 | $142,000 | $47,000 | Dec 22, 2000 |
| 156 | Dancer in the Dark (Fine Line) | $6,996,000 | $153,000 | $51,000 | Sep 22, 2000 |
| 157 | East is East (Miramax) | $6,983,000 | $90,000 | $30,000 | Apr 14, 2000 |
| 158 | Whipped (Destination) | $6,953,000 | $4,563,000 | $1,521,000 | Sep 01, 2000 |
| 159 | Requiem for a Dream (Artisan) | $6,077,000 | $108,000 | $36,000 | Oct 06, 2000 |
| 160 | The Big Blue: Director's Cut (2000) (IDP) | $5,986,000 | $24,000 | $8,000 | Jul 14, 2000 |
| 161 | Malèna (Miramax) | $5,764,000 | $104,000 | $35,000 | Dec 22, 2000 |
| 162 | Price of Glory (New Line) | $5,752,000 | $2,694,000 | $898,000 | Mar 31, 2000 |
| 163 | Ghost Dog: The Way of the Samurai (Artisan) | $5,530,000 | $278,000 | $93,000 | Mar 03, 2000 |
| 164 | The Big Kahuna (Lions Gate) | $5,292,000 | $135,000 | $45,000 | Apr 28, 2000 |
| 165 | Beautiful (Destination) | $5,279,000 | $2,356,000 | $785,000 | Sep 29, 2000 |
| 166 | The House of Mirth (Sony Classics) | $5,088,000 | $82,000 | $27,000 | Dec 22, 2000 |
