| 1 | How the Grinch Stole Christmas (2000) (Universal) | $415,395,000 | $87,989,000 | $29,330,000 | Nov 17, 2000 |
| 2 | Cast Away (Fox) | $373,205,000 | $46,141,000 | $15,380,000 | Dec 22, 2000 |
| 3 | Mission: Impossible II (Paramount) | $344,095,000 | $92,403,000 | $30,801,000 | May 24, 2000 |
| 4 | Gladiator (2000) (DreamWorks) | $299,841,000 | $55,620,000 | $18,540,000 | May 05, 2000 |
| 5 | What Women Want (2000) (Paramount) | $292,024,000 | $53,696,000 | $17,899,000 | Dec 15, 2000 |
| 6 | The Perfect Storm (Warner Bros.) | $291,715,000 | $66,016,000 | $22,005,000 | Jun 30, 2000 |
| 7 | Meet the Parents (Universal) | $265,560,000 | $45,721,000 | $15,240,000 | Oct 06, 2000 |
| 8 | X-Men (Fox) | $251,270,000 | $87,014,000 | $29,005,000 | Jul 14, 2000 |
| 9 | Scary Movie (Miramax / Dimension) | $250,824,000 | $67,645,000 | $22,548,000 | Jul 07, 2000 |
| 10 | What Lies Beneath (DreamWorks) | $248,332,000 | $47,448,000 | $15,816,000 | Jul 21, 2000 |
| 11 | Dinosaur (Disney) | $220,040,000 | $62,067,000 | $20,689,000 | May 19, 2000 |
| 12 | Crouching Tiger, Hidden Dragon (Sony Pictures Classics) | $204,593,000 | $1,058,000 | $353,000 | Dec 08, 2000 |
| 13 | Erin Brockovich (Universal) | $200,627,000 | $44,949,000 | $14,983,000 | Mar 17, 2000 |
| 14 | Charlie's Angels (2000) (Sony / Columbia) | $200,163,000 | $64,103,000 | $21,368,000 | Nov 03, 2000 |
| 15 | Traffic (USA Films) | $198,263,000 | $24,790,000 | $8,263,000 | Dec 27, 2000 |
| 16 | Nutty Professor II: The Klumps (Universal) | $196,975,000 | $67,918,000 | $22,639,000 | Jul 28, 2000 |
| 17 | Big Momma's House (Fox) | $187,789,000 | $40,989,000 | $13,663,000 | Jun 02, 2000 |
| 18 | Remember the Titans (Disney) | $184,746,000 | $33,395,000 | $11,132,000 | Sep 29, 2000 |
| 19 | The Patriot (Sony / Columbia) | $181,034,000 | $35,805,000 | $11,935,000 | Jun 28, 2000 |
| 20 | Chicken Run (DreamWorks) | $170,657,000 | $27,964,000 | $9,321,000 | Jun 21, 2000 |
| 21 | Miss Congeniality (Warner Bros.) | $170,614,000 | $22,130,000 | $7,377,000 | Dec 22, 2000 |
| 22 | Gone in 60 Seconds (Disney) | $162,373,000 | $40,471,000 | $13,490,000 | Jun 09, 2000 |
| 23 | Unbreakable (Disney) | $151,771,000 | $48,452,000 | $16,151,000 | Nov 22, 2000 |
| 24 | Me, Myself & Irene (Fox) | $144,677,000 | $38,672,000 | $12,891,000 | Jun 23, 2000 |
| 25 | Space Cowboys (Warner Bros.) | $144,509,000 | $28,903,000 | $9,634,000 | Aug 04, 2000 |
| 26 | The Emperor's New Groove (Disney) | $142,652,000 | $15,674,000 | $5,225,000 | Dec 15, 2000 |
| 27 | Scream 3 (Miramax / Dimension) | $142,398,000 | $55,451,000 | $18,484,000 | Feb 04, 2000 |
| 28 | U-571 (Universal) | $123,195,000 | $31,235,000 | $10,412,000 | Apr 21, 2000 |
| 29 | Rugrats in Paris: The Movie (Paramount) | $122,213,000 | $36,290,000 | $12,097,000 | Nov 17, 2000 |
| 30 | The Family Man (Universal) | $121,072,000 | $24,127,000 | $8,042,000 | Dec 22, 2000 |
| 31 | Hollow Man (Sony / Columbia) | $116,945,000 | $42,194,000 | $14,065,000 | Aug 04, 2000 |
| 32 | Chocolat (2000) (Miramax) | $114,229,000 | $252,000 | $84,000 | Dec 15, 2000 |
| 33 | Shaft (Paramount) | $112,353,000 | $34,687,000 | $11,562,000 | Jun 16, 2000 |
| 34 | Disney's The Kid (Disney) | $111,326,000 | $20,267,000 | $6,756,000 | Jul 07, 2000 |
| 35 | Vertical Limit (Sony / Columbia) | $110,609,000 | $24,772,000 | $8,257,000 | Dec 08, 2000 |
| 36 | Road Trip (DreamWorks) | $109,487,000 | $24,735,000 | $8,245,000 | May 19, 2000 |
| 37 | Bring It On (Universal) | $109,229,000 | $27,732,000 | $9,244,000 | Aug 25, 2000 |
| 38 | 102 Dalmatians (Disney) | $106,959,000 | $31,764,000 | $10,588,000 | Nov 22, 2000 |
| 39 | Rules of Engagement (Paramount) | $97,977,000 | $23,979,000 | $7,993,000 | Apr 07, 2000 |
| 40 | The Cell (New Line) | $97,975,000 | $27,979,000 | $9,326,000 | Aug 18, 2000 |
| 41 | Mission to Mars (Disney) | $97,255,000 | $36,509,000 | $12,170,000 | Mar 10, 2000 |
| 42 | Coyote Ugly (Disney) | $97,100,000 | $27,666,000 | $9,222,000 | Aug 04, 2000 |
| 43 | Fantasia 2000 (Disney) | $96,891,000 | $3,659,000 | $1,220,000 | Jan 01, 2000 |
| 44 | Snow Day (Paramount) | $95,876,000 | $22,894,000 | $7,631,000 | Feb 11, 2000 |
| 45 | Next Friday (New Line) | $91,577,000 | $23,148,000 | $7,716,000 | Jan 12, 2000 |
| 46 | The Whole Nine Yards (Warner Bros.) | $91,471,000 | $21,936,000 | $7,312,000 | Feb 18, 2000 |
| 47 | Shanghai Noon (Disney) | $90,952,000 | $24,931,000 | $8,310,000 | May 26, 2000 |
| 48 | Romeo Must Die (Warner Bros.) | $89,413,000 | $28,776,000 | $9,592,000 | Mar 22, 2000 |
| 49 | Final Destination (New Line) | $85,193,000 | $15,999,000 | $5,333,000 | Mar 17, 2000 |
| 50 | Finding Forrester (Sony / Columbia) | $82,752,000 | $1,120,000 | $373,000 | Dec 22, 2000 |
| 51 | The Road to El Dorado (DreamWorks) | $81,249,000 | $20,521,000 | $6,840,000 | Mar 31, 2000 |
| 52 | Men of Honor (Fox) | $77,982,000 | $21,308,000 | $7,103,000 | Nov 10, 2000 |
| 53 | Dude, Where's My Car? (Fox) | $74,645,000 | $22,117,000 | $7,372,000 | Dec 15, 2000 |
| 54 | The Tigger Movie (Disney) | $72,768,000 | $15,058,000 | $5,019,000 | Feb 11, 2000 |
| 55 | O Brother, Where Art Thou? (Disney) | $72,703,000 | $312,000 | $104,000 | Dec 22, 2000 |
| 56 | Frequency (New Line) | $71,899,000 | $14,417,000 | $4,806,000 | Apr 28, 2000 |
| 57 | The Replacements (Warner Bros.) | $71,464,000 | $17,634,000 | $5,878,000 | Aug 11, 2000 |
| 58 | Pokemon: The Movie 2000 (Warner Bros.) | $69,900,000 | $31,270,000 | $10,423,000 | Jul 21, 2000 |
| 59 | The Beach (Fox) | $63,554,000 | $24,405,000 | $8,135,000 | Feb 11, 2000 |
| 60 | The Exorcist: The Version You've Never Seen (Warner Bros.) | $63,372,000 | $13,060,000 | $4,353,000 | Sep 22, 2000 |
| 61 | Little Nicky (New Line) | $63,041,000 | $25,661,000 | $8,554,000 | Nov 10, 2000 |
| 62 | Pitch Black (USA Films) | $62,683,000 | $18,584,000 | $6,195,000 | Feb 18, 2000 |
| 63 | The Original Kings of Comedy (Paramount) | $60,993,000 | $17,657,000 | $5,886,000 | Aug 18, 2000 |
| 64 | Bedazzled (2000) (Fox) | $60,521,000 | $20,936,000 | $6,979,000 | Oct 20, 2000 |
| 65 | Autumn in New York (MGM) | $60,321,000 | $17,551,000 | $5,850,000 | Aug 11, 2000 |
| 66 | 28 Days (Sony / Columbia) | $59,376,000 | $16,470,000 | $5,490,000 | Apr 14, 2000 |
| 67 | Keeping the Faith (Disney) | $59,179,000 | $12,905,000 | $4,302,000 | Apr 14, 2000 |
| 68 | Bounce (Miramax) | $58,793,000 | $18,248,000 | $6,083,000 | Nov 17, 2000 |
| 69 | Hanging Up (Sony / Columbia) | $57,587,000 | $25,096,000 | $8,365,000 | Feb 18, 2000 |
| 70 | The Flintstones in Viva Rock Vegas (Universal) | $56,339,000 | $16,802,000 | $5,601,000 | Apr 28, 2000 |
| 71 | The Skulls (Universal) | $55,983,000 | $17,630,000 | $5,877,000 | Mar 31, 2000 |
| 72 | The 6th Day (Sony / Columbia) | $55,277,000 | $20,801,000 | $6,934,000 | Nov 17, 2000 |
| 73 | Thirteen Days (New Line) | $55,258,000 | $15,605,000 | $5,202,000 | Dec 25, 2000 |
| 74 | My Dog Skip (Warner Bros.) | $54,527,000 | $91,000 | $30,000 | Jan 14, 2000 |
| 75 | Where the Heart Is (Fox) | $53,948,000 | $13,247,000 | $4,416,000 | Apr 28, 2000 |
| 76 | Pay It Forward (Warner Bros.) | $53,543,000 | $15,385,000 | $5,128,000 | Oct 20, 2000 |
| 77 | Dracula 2000 (Miramax / Dimension) | $52,750,000 | $13,796,000 | $4,599,000 | Dec 22, 2000 |
| 78 | Return to Me (MGM) | $52,271,000 | $12,493,000 | $4,164,000 | Apr 07, 2000 |
| 79 | Proof of Life (Warner Bros.) | $52,072,000 | $16,306,000 | $5,435,000 | Dec 08, 2000 |
| 80 | Almost Famous (DreamWorks) | $51,971,000 | $3,697,000 | $1,232,000 | Sep 15, 2000 |
| 81 | The Legend of Bagger Vance (DreamWorks) | $49,391,000 | $18,396,000 | $6,132,000 | Nov 03, 2000 |
| 82 | Snatch (Sony / Screen Gems) | $48,447,000 | $45,000 | $15,000 | Dec 08, 2000 |
| 83 | The Art of War (Warner Bros.) | $48,256,000 | $16,631,000 | $5,544,000 | Aug 25, 2000 |
| 84 | Bless the Child (Paramount) | $46,933,000 | $15,037,000 | $5,012,000 | Aug 11, 2000 |
| 85 | The Watcher (Universal) | $46,240,000 | $14,477,000 | $4,826,000 | Sep 08, 2000 |
| 86 | Love & Basketball (New Line) | $43,864,000 | $13,002,000 | $4,334,000 | Apr 21, 2000 |
| 87 | High Fidelity (Disney) | $43,589,000 | $10,270,000 | $3,423,000 | Mar 31, 2000 |
| 88 | Book of Shadows: Blair Witch 2 (Artisan) | $42,231,000 | $21,124,000 | $7,041,000 | Oct 27, 2000 |
| 89 | The Adventures of Rocky & Bullwinkle (Universal) | $41,541,000 | $10,885,000 | $3,628,000 | Jun 30, 2000 |
| 90 | Nurse Betty (USA Films) | $40,208,000 | $11,415,000 | $3,805,000 | Sep 08, 2000 |
| 91 | Reindeer Games (Miramax / Dimension) | $37,329,000 | $12,984,000 | $4,328,000 | Feb 25, 2000 |
| 92 | Titan A.E. (Fox) | $36,346,000 | $14,979,000 | $4,993,000 | Jun 16, 2000 |
| 93 | Billy Elliot (Universal Focus) | $35,135,000 | $345,000 | $115,000 | Oct 13, 2000 |
| 94 | Boys and Girls (Miramax / Dimension) | $34,823,000 | $11,196,000 | $3,732,000 | Jun 16, 2000 |
| 95 | Battlefield Earth (Warner Bros.) | $34,299,000 | $18,448,000 | $6,149,000 | May 12, 2000 |
| 96 | Urban Legends: Final Cut (Sony / Columbia) | $34,294,000 | $13,587,000 | $4,529,000 | Sep 22, 2000 |
| 97 | Down to You (Miramax) | $32,060,000 | $12,144,000 | $4,048,000 | Jan 21, 2000 |
| 98 | Wonder Boys (Paramount) | $30,979,000 | $9,279,000 | $3,093,000 | Feb 23, 2000 |
| 99 | Best in Show (Warner Bros.) | $29,896,000 | $660,000 | $220,000 | Sep 29, 2000 |
| 100 | The Ninth Gate (Artisan) | $29,810,000 | $10,579,000 | $3,526,000 | Mar 10, 2000 |
| 101 | Michael Jordan to the Max (IMAX) | $29,793,000 | $924,000 | $308,000 | May 05, 2000 |
| 102 | The Contender (DreamWorks) | $28,550,000 | $8,568,000 | $2,856,000 | Oct 13, 2000 |
| 103 | Red Planet (Warner Bros.) | $27,924,000 | $13,931,000 | $4,644,000 | Nov 10, 2000 |
| 104 | Small Time Crooks (DreamWorks) | $27,582,000 | $6,200,000 | $2,067,000 | May 19, 2000 |
| 105 | Center Stage (Sony / Columbia) | $27,475,000 | $7,355,000 | $2,452,000 | May 12, 2000 |
| 106 | Boiler Room (New Line) | $27,109,000 | $10,739,000 | $3,580,000 | Feb 18, 2000 |
| 107 | Lost Souls (New Line) | $26,861,000 | $12,707,000 | $4,236,000 | Oct 13, 2000 |
| 108 | Eye of the Beholder (Destination) | $26,359,000 | $9,520,000 | $3,173,000 | Jan 28, 2000 |
| 109 | Thomas and the Magic Railroad (Destination) | $25,453,000 | $6,637,000 | $2,212,000 | Jul 26, 2000 |
| 110 | Cirque du Soleil: Journey of Man (Sony Pictures Classics) | $24,963,000 | $80,000 | $27,000 | May 05, 2000 |
| 111 | Loser (Sony / Columbia) | $24,949,000 | $9,598,000 | $3,199,000 | Jul 21, 2000 |
| 112 | All the Pretty Horses (Miramax) | $24,824,000 | $7,764,000 | $2,588,000 | Dec 25, 2000 |
| 113 | Drowning Mona (Destination) | $24,770,000 | $9,268,000 | $3,089,000 | Mar 03, 2000 |
| 114 | Bait (Warner Bros.) | $24,481,000 | $8,763,000 | $2,921,000 | Sep 15, 2000 |
| 115 | Dungeons & Dragons (New Line) | $24,314,000 | $11,561,000 | $3,854,000 | Dec 08, 2000 |
| 116 | American Psycho (Lionsgate) | $24,074,000 | $7,925,000 | $2,642,000 | Apr 14, 2000 |
| 117 | The Next Best Thing (Paramount) | $23,945,000 | $9,377,000 | $3,126,000 | Mar 03, 2000 |
| 118 | Get Carter (Warner Bros.) | $23,909,000 | $10,603,000 | $3,534,000 | Oct 06, 2000 |
| 119 | Supernova (MGM) | $22,732,000 | $10,754,000 | $3,585,000 | Jan 14, 2000 |
| 120 | The Ladies Man (Paramount) | $21,751,000 | $8,668,000 | $2,889,000 | Oct 13, 2000 |
| 121 | The Little Vampire (New Line) | $21,681,000 | $9,137,000 | $3,046,000 | Oct 27, 2000 |
| 122 | Dr. T and the Women (Artisan) | $20,948,000 | $8,008,000 | $2,669,000 | Oct 12, 2000 |
| 123 | The Crew (Disney) | $20,803,000 | $6,473,000 | $2,158,000 | Aug 25, 2000 |
| 124 | Highlander: Endgame (Miramax / Dimension) | $20,465,000 | $9,941,000 | $3,314,000 | Sep 01, 2000 |
| 125 | Ready to Rumble (Warner Bros.) | $19,800,000 | $8,399,000 | $2,800,000 | Apr 07, 2000 |
| 126 | Saving Grace (Fine Line) | $19,454,000 | $459,000 | $153,000 | Aug 04, 2000 |
| 127 | The Gift (2000) (Paramount Classics) | $19,183,000 | $19,000 | $6,000 | Dec 22, 2000 |
| 128 | The Legend of Drunken Master (Miramax / Dimension) | $18,459,000 | $6,142,000 | $2,047,000 | Oct 20, 2000 |
| 129 | Cyberworld 3-D (IMAX) | $17,976,000 | $444,000 | $148,000 | Oct 06, 2000 |
| 130 | Here on Earth (Fox) | $16,809,000 | $7,205,000 | $2,402,000 | Mar 15, 2000 |
| 131 | Lucky Numbers (Paramount) | $16,041,000 | $7,247,000 | $2,416,000 | Oct 27, 2000 |
| 132 | Godzilla 2000 (Sony / TriStar) | $16,034,000 | $7,041,000 | $2,347,000 | Aug 18, 2000 |
| 133 | 3 Strikes (MGM) | $15,707,000 | $5,886,000 | $1,962,000 | Mar 03, 2000 |
| 134 | Digimon: The Movie (Fox) | $15,385,000 | $6,762,000 | $2,254,000 | Oct 06, 2000 |
| 135 | You Can Count on Me (Paramount Classics) | $14,670,000 | $189,000 | $63,000 | Nov 10, 2000 |
| 136 | Whatever It Takes (Sony / Columbia) | $13,971,000 | $6,556,000 | $2,185,000 | Mar 24, 2000 |
| 137 | Pollock (Sony Pictures Classics) | $13,735,000 | $71,000 | $24,000 | Dec 15, 2000 |
| 138 | Shadow of the Vampire (Lionsgate) | $13,248,000 | $240,000 | $80,000 | Dec 29, 2000 |
| 139 | Quills (Fox Searchlight) | $11,286,000 | $398,000 | $133,000 | Nov 24, 2000 |
| 140 | Screwed (Universal) | $11,226,000 | $5,336,000 | $1,779,000 | May 12, 2000 |
| 141 | State and Main (Fine Line) | $11,093,000 | $927,000 | $309,000 | Dec 22, 2000 |
| 142 | I Dreamed of Africa (Sony / Columbia) | $10,624,000 | $3,852,000 | $1,284,000 | May 05, 2000 |
| 143 | What Planet Are You From? (Sony / Columbia) | $10,050,000 | $4,806,000 | $1,602,000 | Mar 03, 2000 |
| 144 | Croupier (Shooting Gallery) | $9,906,000 | $101,000 | $34,000 | Apr 21, 2000 |
| 145 | The Way of the Gun (Artisan) | $9,673,000 | $3,436,000 | $1,145,000 | Sep 08, 2000 |
| 146 | Where the Money Is (USA Films) | $9,043,000 | $4,015,000 | $1,338,000 | Apr 14, 2000 |
| 147 | The In Crowd (Warner Bros.) | $8,436,000 | $2,405,000 | $802,000 | Jul 21, 2000 |
| 148 | Black and White (Sony / Columbia) | $8,431,000 | $3,534,000 | $1,178,000 | Apr 07, 2000 |
| 149 | Gossip (Warner Bros.) | $8,160,000 | $3,709,000 | $1,236,000 | Apr 21, 2000 |
| 150 | Woman on Top (Fox Searchlight) | $8,019,000 | $3,208,000 | $1,069,000 | Sep 22, 2000 |
| 151 | The Virgin Suicides (Paramount Classics) | $7,837,000 | $376,000 | $125,000 | Apr 21, 2000 |
| 152 | Duets (Disney) | $7,571,000 | $3,199,000 | $1,066,000 | Sep 15, 2000 |
| 153 | Held Up (Trimark) | $7,517,000 | $3,053,000 | $1,018,000 | May 12, 2000 |
| 154 | The Tao of Steve (Sony Classics) | $6,937,000 | $147,000 | $49,000 | Aug 04, 2000 |
| 155 | Before Night Falls (Fine Line) | $6,776,000 | $136,000 | $45,000 | Dec 22, 2000 |
| 156 | Dancer in the Dark (Fine Line) | $6,685,000 | $146,000 | $49,000 | Sep 22, 2000 |
| 157 | East is East (Miramax) | $6,673,000 | $86,000 | $29,000 | Apr 14, 2000 |
| 158 | Whipped (Destination) | $6,644,000 | $4,360,000 | $1,453,000 | Sep 01, 2000 |
| 159 | Requiem for a Dream (Artisan) | $5,808,000 | $103,000 | $34,000 | Oct 06, 2000 |
| 160 | The Big Blue: Director's Cut (2000) (IDP) | $5,720,000 | $23,000 | $8,000 | Jul 14, 2000 |
| 161 | Malèna (Miramax) | $5,508,000 | $99,000 | $33,000 | Dec 22, 2000 |
| 162 | Price of Glory (New Line) | $5,496,000 | $2,575,000 | $858,000 | Mar 31, 2000 |
| 163 | Ghost Dog: Way of the Samurai (Artisan) | $5,285,000 | $266,000 | $89,000 | Mar 03, 2000 |
| 164 | The Big Kahuna (Lions Gate) | $5,057,000 | $129,000 | $43,000 | Apr 28, 2000 |
| 165 | Beautiful (Destination) | $5,044,000 | $2,251,000 | $750,000 | Sep 29, 2000 |
