| 1 | How the Grinch Stole Christmas (2000) (Universal) | $428,904,000 | $90,851,000 | $30,284,000 | Nov 17, 2000 |
| 2 | Cast Away (Fox) | $385,342,000 | $47,641,000 | $15,880,000 | Dec 22, 2000 |
| 3 | Mission: Impossible II (Paramount) | $355,285,000 | $95,408,000 | $31,803,000 | May 24, 2000 |
| 4 | Gladiator (2000) (DreamWorks) | $309,592,000 | $57,429,000 | $19,143,000 | May 05, 2000 |
| 5 | What Women Want (2000) (Paramount) | $301,521,000 | $55,442,000 | $18,481,000 | Dec 15, 2000 |
| 6 | The Perfect Storm (Warner Bros.) | $301,201,000 | $68,163,000 | $22,721,000 | Jun 30, 2000 |
| 7 | Meet the Parents (Universal) | $274,196,000 | $47,208,000 | $15,736,000 | Oct 06, 2000 |
| 8 | X-Men (Fox) | $259,442,000 | $89,844,000 | $29,948,000 | Jul 14, 2000 |
| 9 | Scary Movie (Miramax / Dimension) | $258,980,000 | $69,845,000 | $23,282,000 | Jul 07, 2000 |
| 10 | What Lies Beneath (DreamWorks) | $256,408,000 | $48,992,000 | $16,331,000 | Jul 21, 2000 |
| 11 | Dinosaur (Disney) | $227,196,000 | $64,085,000 | $21,362,000 | May 19, 2000 |
| 12 | Crouching Tiger, Hidden Dragon (Sony Pictures Classics) | $211,247,000 | $1,092,000 | $364,000 | Dec 08, 2000 |
| 13 | Erin Brockovich (Universal) | $207,151,000 | $46,411,000 | $15,470,000 | Mar 17, 2000 |
| 14 | Charlie's Angels (2000) (Sony / Columbia) | $206,672,000 | $66,187,000 | $22,062,000 | Nov 03, 2000 |
| 15 | Traffic (USA Films) | $204,710,000 | $25,596,000 | $8,532,000 | Dec 27, 2000 |
| 16 | Nutty Professor II: The Klumps (Universal) | $203,381,000 | $70,127,000 | $23,376,000 | Jul 28, 2000 |
| 17 | Big Momma's House (Fox) | $193,896,000 | $42,322,000 | $14,107,000 | Jun 02, 2000 |
| 18 | Remember the Titans (Disney) | $190,754,000 | $34,481,000 | $11,494,000 | Sep 29, 2000 |
| 19 | The Patriot (Sony / Columbia) | $186,921,000 | $36,969,000 | $12,323,000 | Jun 28, 2000 |
| 20 | Chicken Run (DreamWorks) | $176,207,000 | $28,874,000 | $9,625,000 | Jun 21, 2000 |
| 21 | Miss Congeniality (Warner Bros.) | $176,162,000 | $22,850,000 | $7,617,000 | Dec 22, 2000 |
| 22 | Gone in 60 Seconds (Disney) | $167,653,000 | $41,787,000 | $13,929,000 | Jun 09, 2000 |
| 23 | Unbreakable (Disney) | $156,707,000 | $50,028,000 | $16,676,000 | Nov 22, 2000 |
| 24 | Me, Myself & Irene (Fox) | $149,382,000 | $39,930,000 | $13,310,000 | Jun 23, 2000 |
| 25 | Space Cowboys (Warner Bros.) | $149,208,000 | $29,843,000 | $9,948,000 | Aug 04, 2000 |
| 26 | The Emperor's New Groove (Disney) | $147,291,000 | $16,184,000 | $5,395,000 | Dec 15, 2000 |
| 27 | Scream 3 (Miramax / Dimension) | $147,029,000 | $57,254,000 | $19,085,000 | Feb 04, 2000 |
| 28 | U-571 (Universal) | $127,202,000 | $32,251,000 | $10,750,000 | Apr 21, 2000 |
| 29 | Rugrats in Paris: The Movie (Paramount) | $126,188,000 | $37,470,000 | $12,490,000 | Nov 17, 2000 |
| 30 | The Family Man (Universal) | $125,010,000 | $24,912,000 | $8,304,000 | Dec 22, 2000 |
| 31 | Hollow Man (Sony / Columbia) | $120,748,000 | $43,567,000 | $14,522,000 | Aug 04, 2000 |
| 32 | Chocolat (2000) (Miramax) | $117,943,000 | $260,000 | $87,000 | Dec 15, 2000 |
| 33 | Shaft (Paramount) | $116,006,000 | $35,815,000 | $11,938,000 | Jun 16, 2000 |
| 34 | Disney's The Kid (Disney) | $114,946,000 | $20,927,000 | $6,976,000 | Jul 07, 2000 |
| 35 | Vertical Limit (Sony / Columbia) | $114,206,000 | $25,578,000 | $8,526,000 | Dec 08, 2000 |
| 36 | Road Trip (DreamWorks) | $113,047,000 | $25,540,000 | $8,513,000 | May 19, 2000 |
| 37 | Bring It On (Universal) | $112,781,000 | $28,634,000 | $9,545,000 | Aug 25, 2000 |
| 38 | 102 Dalmatians (Disney) | $110,437,000 | $32,797,000 | $10,932,000 | Nov 22, 2000 |
| 39 | Rules of Engagement (Paramount) | $101,164,000 | $24,759,000 | $8,253,000 | Apr 07, 2000 |
| 40 | The Cell (New Line) | $101,161,000 | $28,888,000 | $9,629,000 | Aug 18, 2000 |
| 41 | Mission to Mars (Disney) | $100,417,000 | $37,696,000 | $12,565,000 | Mar 10, 2000 |
| 42 | Coyote Ugly (Disney) | $100,257,000 | $28,566,000 | $9,522,000 | Aug 04, 2000 |
| 43 | Fantasia 2000 (Disney) | $100,042,000 | $3,778,000 | $1,259,000 | Jan 01, 2000 |
| 44 | Snow Day (Paramount) | $98,994,000 | $23,638,000 | $7,879,000 | Feb 11, 2000 |
| 45 | Next Friday (New Line) | $94,555,000 | $23,901,000 | $7,967,000 | Jan 12, 2000 |
| 46 | The Whole Nine Yards (Warner Bros.) | $94,445,000 | $22,649,000 | $7,550,000 | Feb 18, 2000 |
| 47 | Shanghai Noon (Disney) | $93,910,000 | $25,742,000 | $8,581,000 | May 26, 2000 |
| 48 | Romeo Must Die (Warner Bros.) | $92,321,000 | $29,712,000 | $9,904,000 | Mar 22, 2000 |
| 49 | Final Destination (New Line) | $87,963,000 | $16,520,000 | $5,507,000 | Mar 17, 2000 |
| 50 | Finding Forrester (Sony / Columbia) | $85,443,000 | $1,157,000 | $386,000 | Dec 22, 2000 |
| 51 | The Road to El Dorado (DreamWorks) | $83,891,000 | $21,188,000 | $7,063,000 | Mar 31, 2000 |
| 52 | Men of Honor (Fox) | $80,518,000 | $22,001,000 | $7,334,000 | Nov 10, 2000 |
| 53 | Dude, Where's My Car? (Fox) | $77,073,000 | $22,837,000 | $7,612,000 | Dec 15, 2000 |
| 54 | The Tigger Movie (Disney) | $75,135,000 | $15,548,000 | $5,183,000 | Feb 11, 2000 |
| 55 | O Brother, Where Art Thou? (Disney) | $75,067,000 | $322,000 | $107,000 | Dec 22, 2000 |
| 56 | Frequency (New Line) | $74,238,000 | $14,886,000 | $4,962,000 | Apr 28, 2000 |
| 57 | The Replacements (Warner Bros.) | $73,788,000 | $18,208,000 | $6,069,000 | Aug 11, 2000 |
| 58 | Pokemon: The Movie 2000 (Warner Bros.) | $72,173,000 | $32,287,000 | $10,762,000 | Jul 21, 2000 |
| 59 | The Beach (Fox) | $65,621,000 | $25,199,000 | $8,400,000 | Feb 11, 2000 |
| 60 | The Exorcist: The Version You've Never Seen (Warner Bros.) | $65,433,000 | $13,485,000 | $4,495,000 | Sep 22, 2000 |
| 61 | Little Nicky (New Line) | $65,091,000 | $26,495,000 | $8,832,000 | Nov 10, 2000 |
| 62 | Pitch Black (USA Films) | $64,721,000 | $19,189,000 | $6,396,000 | Feb 18, 2000 |
| 63 | The Original Kings of Comedy (Paramount) | $62,976,000 | $18,232,000 | $6,077,000 | Aug 18, 2000 |
| 64 | Bedazzled (2000) (Fox) | $62,489,000 | $21,617,000 | $7,206,000 | Oct 20, 2000 |
| 65 | Autumn in New York (MGM) | $62,282,000 | $18,121,000 | $6,040,000 | Aug 11, 2000 |
| 66 | 28 Days (Sony / Columbia) | $61,307,000 | $17,006,000 | $5,669,000 | Apr 14, 2000 |
| 67 | Keeping the Faith (Disney) | $61,104,000 | $13,325,000 | $4,442,000 | Apr 14, 2000 |
| 68 | Bounce (Miramax) | $60,705,000 | $18,842,000 | $6,281,000 | Nov 17, 2000 |
| 69 | Hanging Up (Sony / Columbia) | $59,459,000 | $25,912,000 | $8,637,000 | Feb 18, 2000 |
| 70 | The Flintstones in Viva Rock Vegas (Universal) | $58,171,000 | $17,348,000 | $5,783,000 | Apr 28, 2000 |
| 71 | The Skulls (Universal) | $57,803,000 | $18,204,000 | $6,068,000 | Mar 31, 2000 |
| 72 | The 6th Day (Sony / Columbia) | $57,075,000 | $21,477,000 | $7,159,000 | Nov 17, 2000 |
| 73 | Thirteen Days (New Line) | $57,055,000 | $16,112,000 | $5,371,000 | Dec 25, 2000 |
| 74 | My Dog Skip (Warner Bros.) | $56,300,000 | $94,000 | $31,000 | Jan 14, 2000 |
| 75 | Where the Heart Is (Fox) | $55,702,000 | $13,678,000 | $4,559,000 | Apr 28, 2000 |
| 76 | Pay It Forward (Warner Bros.) | $55,285,000 | $15,885,000 | $5,295,000 | Oct 20, 2000 |
| 77 | Dracula 2000 (Miramax / Dimension) | $54,465,000 | $14,245,000 | $4,748,000 | Dec 22, 2000 |
| 78 | Return to Me (MGM) | $53,970,000 | $12,899,000 | $4,300,000 | Apr 07, 2000 |
| 79 | Proof of Life (Warner Bros.) | $53,766,000 | $16,836,000 | $5,612,000 | Dec 08, 2000 |
| 80 | Almost Famous (DreamWorks) | $53,661,000 | $3,818,000 | $1,273,000 | Sep 15, 2000 |
| 81 | The Legend of Bagger Vance (DreamWorks) | $50,997,000 | $18,995,000 | $6,332,000 | Nov 03, 2000 |
| 82 | Snatch (Sony / Screen Gems) | $50,022,000 | $46,000 | $15,000 | Dec 08, 2000 |
| 83 | The Art of War (Warner Bros.) | $49,825,000 | $17,171,000 | $5,724,000 | Aug 25, 2000 |
| 84 | Bless the Child (Paramount) | $48,460,000 | $15,526,000 | $5,175,000 | Aug 11, 2000 |
| 85 | The Watcher (Universal) | $47,743,000 | $14,948,000 | $4,983,000 | Sep 08, 2000 |
| 86 | Love & Basketball (New Line) | $45,291,000 | $13,424,000 | $4,475,000 | Apr 21, 2000 |
| 87 | High Fidelity (Disney) | $45,007,000 | $10,604,000 | $3,535,000 | Mar 31, 2000 |
| 88 | Book of Shadows: Blair Witch 2 (Artisan) | $43,604,000 | $21,811,000 | $7,270,000 | Oct 27, 2000 |
| 89 | The Adventures of Rocky & Bullwinkle (Universal) | $42,892,000 | $11,239,000 | $3,746,000 | Jun 30, 2000 |
| 90 | Nurse Betty (USA Films) | $41,515,000 | $11,786,000 | $3,929,000 | Sep 08, 2000 |
| 91 | Reindeer Games (Miramax / Dimension) | $38,543,000 | $13,407,000 | $4,469,000 | Feb 25, 2000 |
| 92 | Titan A.E. (Fox) | $37,528,000 | $15,466,000 | $5,155,000 | Jun 16, 2000 |
| 93 | Billy Elliot (Universal Focus) | $36,277,000 | $356,000 | $119,000 | Oct 13, 2000 |
| 94 | Boys and Girls (Miramax / Dimension) | $35,956,000 | $11,560,000 | $3,853,000 | Jun 16, 2000 |
| 95 | Battlefield Earth (Warner Bros.) | $35,414,000 | $19,048,000 | $6,349,000 | May 12, 2000 |
| 96 | Urban Legends: Final Cut (Sony / Columbia) | $35,409,000 | $14,029,000 | $4,676,000 | Sep 22, 2000 |
| 97 | Down to You (Miramax) | $33,102,000 | $12,539,000 | $4,180,000 | Jan 21, 2000 |
| 98 | Wonder Boys (Paramount) | $31,986,000 | $9,581,000 | $3,194,000 | Feb 23, 2000 |
| 99 | Best in Show (Warner Bros.) | $30,869,000 | $682,000 | $227,000 | Sep 29, 2000 |
| 100 | The Ninth Gate (Artisan) | $30,780,000 | $10,923,000 | $3,641,000 | Mar 10, 2000 |
| 101 | Michael Jordan to the Max (IMAX) | $30,762,000 | $954,000 | $318,000 | May 05, 2000 |
| 102 | The Contender (DreamWorks) | $29,478,000 | $8,847,000 | $2,949,000 | Oct 13, 2000 |
| 103 | Red Planet (Warner Bros.) | $28,832,000 | $14,384,000 | $4,795,000 | Nov 10, 2000 |
| 104 | Small Time Crooks (DreamWorks) | $28,479,000 | $6,401,000 | $2,134,000 | May 19, 2000 |
| 105 | Center Stage (Sony / Columbia) | $28,369,000 | $7,595,000 | $2,532,000 | May 12, 2000 |
| 106 | Boiler Room (New Line) | $27,991,000 | $11,088,000 | $3,696,000 | Feb 18, 2000 |
| 107 | Lost Souls (New Line) | $27,734,000 | $13,120,000 | $4,373,000 | Oct 13, 2000 |
| 108 | Eye of the Beholder (Destination) | $27,216,000 | $9,829,000 | $3,276,000 | Jan 28, 2000 |
| 109 | Thomas and the Magic Railroad (Destination) | $26,280,000 | $6,853,000 | $2,284,000 | Jul 26, 2000 |
| 110 | Cirque du Soleil: Journey of Man (Sony Pictures Classics) | $25,775,000 | $82,000 | $27,000 | May 05, 2000 |
| 111 | Loser (Sony / Columbia) | $25,760,000 | $9,910,000 | $3,303,000 | Jul 21, 2000 |
| 112 | All the Pretty Horses (Miramax) | $25,631,000 | $8,017,000 | $2,672,000 | Dec 25, 2000 |
| 113 | Drowning Mona (Destination) | $25,575,000 | $9,570,000 | $3,190,000 | Mar 03, 2000 |
| 114 | Bait (Warner Bros.) | $25,278,000 | $9,048,000 | $3,016,000 | Sep 15, 2000 |
| 115 | Dungeons & Dragons (New Line) | $25,104,000 | $11,937,000 | $3,979,000 | Dec 08, 2000 |
| 116 | American Psycho (Lionsgate) | $24,857,000 | $8,182,000 | $2,727,000 | Apr 14, 2000 |
| 117 | The Next Best Thing (Paramount) | $24,724,000 | $9,682,000 | $3,227,000 | Mar 03, 2000 |
| 118 | Get Carter (Warner Bros.) | $24,686,000 | $10,948,000 | $3,649,000 | Oct 06, 2000 |
| 119 | Supernova (MGM) | $23,471,000 | $11,103,000 | $3,701,000 | Jan 14, 2000 |
| 120 | The Ladies Man (Paramount) | $22,458,000 | $8,950,000 | $2,983,000 | Oct 13, 2000 |
| 121 | The Little Vampire (New Line) | $22,386,000 | $9,434,000 | $3,145,000 | Oct 27, 2000 |
| 122 | Dr. T and the Women (Artisan) | $21,630,000 | $8,268,000 | $2,756,000 | Oct 12, 2000 |
| 123 | The Crew (Disney) | $21,480,000 | $6,683,000 | $2,228,000 | Aug 25, 2000 |
| 124 | Highlander: Endgame (Miramax / Dimension) | $21,131,000 | $10,264,000 | $3,421,000 | Sep 01, 2000 |
| 125 | Ready to Rumble (Warner Bros.) | $20,443,000 | $8,672,000 | $2,891,000 | Apr 07, 2000 |
| 126 | Saving Grace (Fine Line) | $20,087,000 | $474,000 | $158,000 | Aug 04, 2000 |
| 127 | The Gift (2000) (Paramount Classics) | $19,807,000 | $20,000 | $7,000 | Dec 22, 2000 |
| 128 | The Legend of Drunken Master (Miramax / Dimension) | $19,059,000 | $6,342,000 | $2,114,000 | Oct 20, 2000 |
| 129 | Cyberworld 3-D (IMAX) | $18,561,000 | $459,000 | $153,000 | Oct 06, 2000 |
| 130 | Here on Earth (Fox) | $17,355,000 | $7,440,000 | $2,480,000 | Mar 15, 2000 |
| 131 | Lucky Numbers (Paramount) | $16,563,000 | $7,482,000 | $2,494,000 | Oct 27, 2000 |
| 132 | Godzilla 2000 (Sony / TriStar) | $16,555,000 | $7,270,000 | $2,423,000 | Aug 18, 2000 |
| 133 | 3 Strikes (MGM) | $16,217,000 | $6,077,000 | $2,026,000 | Mar 03, 2000 |
| 134 | Digimon: The Movie (Fox) | $15,886,000 | $6,982,000 | $2,327,000 | Oct 06, 2000 |
| 135 | You Can Count on Me (Paramount Classics) | $15,147,000 | $195,000 | $65,000 | Nov 10, 2000 |
| 136 | Whatever It Takes (Sony / Columbia) | $14,425,000 | $6,769,000 | $2,256,000 | Mar 24, 2000 |
| 137 | Pollock (Sony Pictures Classics) | $14,181,000 | $73,000 | $24,000 | Dec 15, 2000 |
| 138 | Shadow of the Vampire (Lionsgate) | $13,678,000 | $248,000 | $83,000 | Dec 29, 2000 |
| 139 | Quills (Fox Searchlight) | $11,653,000 | $411,000 | $137,000 | Nov 24, 2000 |
| 140 | Screwed (Universal) | $11,591,000 | $5,510,000 | $1,837,000 | May 12, 2000 |
| 141 | State and Main (Fine Line) | $11,454,000 | $957,000 | $319,000 | Dec 22, 2000 |
| 142 | I Dreamed of Africa (Sony / Columbia) | $10,970,000 | $3,977,000 | $1,326,000 | May 05, 2000 |
| 143 | What Planet Are You From? (Sony / Columbia) | $10,377,000 | $4,962,000 | $1,654,000 | Mar 03, 2000 |
| 144 | Croupier (Shooting Gallery) | $10,229,000 | $105,000 | $35,000 | Apr 21, 2000 |
| 145 | The Way of the Gun (Artisan) | $9,988,000 | $3,548,000 | $1,183,000 | Sep 08, 2000 |
| 146 | Where the Money Is (USA Films) | $9,337,000 | $4,146,000 | $1,382,000 | Apr 14, 2000 |
| 147 | The In Crowd (Warner Bros.) | $8,710,000 | $2,483,000 | $828,000 | Jul 21, 2000 |
| 148 | Black and White (Sony / Columbia) | $8,705,000 | $3,649,000 | $1,216,000 | Apr 07, 2000 |
| 149 | Gossip (Warner Bros.) | $8,425,000 | $3,829,000 | $1,276,000 | Apr 21, 2000 |
| 150 | Woman on Top (Fox Searchlight) | $8,280,000 | $3,312,000 | $1,104,000 | Sep 22, 2000 |
| 151 | The Virgin Suicides (Paramount Classics) | $8,092,000 | $388,000 | $129,000 | Apr 21, 2000 |
| 152 | Duets (Disney) | $7,818,000 | $3,303,000 | $1,101,000 | Sep 15, 2000 |
| 153 | Held Up (Trimark) | $7,762,000 | $3,152,000 | $1,051,000 | May 12, 2000 |
| 154 | The Tao of Steve (Sony Classics) | $7,162,000 | $151,000 | $50,000 | Aug 04, 2000 |
| 155 | Before Night Falls (Fine Line) | $6,997,000 | $141,000 | $47,000 | Dec 22, 2000 |
| 156 | Dancer in the Dark (Fine Line) | $6,902,000 | $151,000 | $50,000 | Sep 22, 2000 |
| 157 | East is East (Miramax) | $6,890,000 | $88,000 | $29,000 | Apr 14, 2000 |
| 158 | Whipped (Destination) | $6,860,000 | $4,502,000 | $1,501,000 | Sep 01, 2000 |
| 159 | Requiem for a Dream (Artisan) | $5,997,000 | $107,000 | $36,000 | Oct 06, 2000 |
| 160 | The Big Blue: Director's Cut (2000) (IDP) | $5,906,000 | $23,000 | $8,000 | Jul 14, 2000 |
| 161 | Malèna (Miramax) | $5,687,000 | $103,000 | $34,000 | Dec 22, 2000 |
| 162 | Price of Glory (New Line) | $5,675,000 | $2,658,000 | $886,000 | Mar 31, 2000 |
| 163 | Ghost Dog: Way of the Samurai (Artisan) | $5,457,000 | $274,000 | $91,000 | Mar 03, 2000 |
| 164 | The Big Kahuna (Lions Gate) | $5,222,000 | $134,000 | $45,000 | Apr 28, 2000 |
| 165 | Beautiful (Destination) | $5,208,000 | $2,325,000 | $775,000 | Sep 29, 2000 |
| 166 | The House of Mirth (Sony Classics) | $5,021,000 | $80,000 | $27,000 | Dec 22, 2000 |
