| 1 | Toy Story 3 (Disney) | $452,876,000 | $120,373,000 | $40,124,000 | Jun 18, 2010 |
| 2 | Alice in Wonderland (2010) (Disney) | $364,688,000 | $126,696,000 | $42,232,000 | Mar 05, 2010 |
| 3 | Iron Man 2 (Paramount) | $340,612,000 | $139,814,000 | $46,605,000 | May 07, 2010 |
| 4 | The Twilight Saga: Eclipse (Summit) | $327,957,000 | $70,748,000 | $23,583,000 | Jun 30, 2010 |
| 5 | Harry Potter and the Deathly Hallows: Part 1 (Warner Bros.) | $322,993,000 | $136,426,000 | $45,475,000 | Nov 19, 2010 |
| 6 | Inception (Warner Bros.) | $319,275,000 | $68,515,000 | $22,838,000 | Jul 16, 2010 |
| 7 | Despicable Me (Universal) | $274,466,000 | $61,544,000 | $20,515,000 | Jul 09, 2010 |
| 8 | Shrek Forever After (Paramount / DreamWorks) | $260,151,000 | $77,303,000 | $25,768,000 | May 21, 2010 |
| 9 | How to Train Your Dragon (Paramount / DreamWorks) | $237,437,000 | $47,723,000 | $15,908,000 | Mar 26, 2010 |
| 10 | Tangled (Disney) | $219,148,000 | $53,217,000 | $17,739,000 | Nov 24, 2010 |
| 11 | The Karate Kid (2010) (Sony / Columbia) | $192,706,000 | $60,746,000 | $20,249,000 | Jun 11, 2010 |
| 12 | TRON: Legacy (Disney) | $187,764,000 | $48,044,000 | $16,015,000 | Dec 17, 2010 |
| 13 | True Grit (2010) (Paramount) | $186,659,000 | $27,096,000 | $9,032,000 | Dec 22, 2010 |
| 14 | Clash of the Titans (2010) (Warner Bros.) | $178,109,000 | $66,823,000 | $22,274,000 | Apr 02, 2010 |
| 15 | Grown Ups (Sony / Columbia) | $176,785,000 | $44,203,000 | $14,734,000 | Jun 25, 2010 |
| 16 | Little Fockers (Universal) | $161,984,000 | $33,647,000 | $11,216,000 | Dec 22, 2010 |
| 17 | Megamind (Paramount / DreamWorks) | $161,960,000 | $50,216,000 | $16,739,000 | Nov 05, 2010 |
| 18 | The King's Speech (Weinstein Company) | $151,463,000 | $388,000 | $129,000 | Nov 26, 2010 |
| 19 | The Last Airbender (Paramount) | $143,610,000 | $44,005,000 | $14,668,000 | Jul 01, 2010 |
| 20 | Shutter Island (Paramount) | $139,695,000 | $44,810,000 | $14,937,000 | Feb 19, 2010 |
| 21 | The Other Guys (Sony / Columbia) | $130,099,000 | $38,787,000 | $12,929,000 | Aug 06, 2010 |
| 22 | Salt (Sony / Columbia) | $129,108,000 | $39,297,000 | $13,099,000 | Jul 23, 2010 |
| 23 | Jackass 3D (Paramount) | $127,927,000 | $54,949,000 | $18,316,000 | Oct 15, 2010 |
| 24 | Valentine's Day (Warner Bros. / New Line) | $120,568,000 | $61,395,000 | $20,465,000 | Feb 12, 2010 |
| 25 | Black Swan (Fox Searchlight) | $116,715,000 | $1,576,000 | $525,000 | Dec 03, 2010 |
| 26 | Robin Hood (2010) (Universal) | $114,876,000 | $39,354,000 | $13,118,000 | May 14, 2010 |
| 27 | The Chronicles of Narnia: The Voyage of the Dawn Treader (Fox) | $113,913,000 | $26,196,000 | $8,732,000 | Dec 10, 2010 |
| 28 | The Expendables (Lionsgate) | $112,474,000 | $38,003,000 | $12,668,000 | Aug 13, 2010 |
| 29 | Due Date (Warner Bros.) | $109,714,000 | $35,672,000 | $11,891,000 | Nov 05, 2010 |
| 30 | Yogi Bear (Warner Bros.) | $109,394,000 | $17,909,000 | $5,970,000 | Dec 17, 2010 |
| 31 | Date Night (Fox) | $107,719,000 | $27,508,000 | $9,169,000 | Apr 09, 2010 |
| 32 | The Social Network (Sony / Columbia) | $105,811,000 | $24,494,000 | $8,165,000 | Oct 01, 2010 |
| 33 | Sex and the City 2 (Warner Bros. / New Line) | $104,049,000 | $33,831,000 | $11,277,000 | May 27, 2010 |
| 34 | The Book of Eli (Warner Bros.) | $103,489,000 | $35,782,000 | $11,927,000 | Jan 15, 2010 |
| 35 | The Fighter (Paramount) | $102,160,000 | $327,000 | $109,000 | Dec 10, 2010 |
| 36 | The Town (Warner Bros.) | $100,599,000 | $25,981,000 | $8,660,000 | Sep 17, 2010 |
| 37 | Prince of Persia: The Sands of Time (Disney) | $99,042,000 | $32,842,000 | $10,947,000 | May 28, 2010 |
| 38 | Red (2010) (Summit) | $98,628,000 | $23,747,000 | $7,916,000 | Oct 15, 2010 |
| 39 | Percy Jackson and the Olympians: The Lightning Thief (Fox) | $96,862,000 | $34,087,000 | $11,362,000 | Feb 12, 2010 |
| 40 | Paranormal Activity 2 (Paramount) | $92,487,000 | $44,391,000 | $14,797,000 | Oct 22, 2010 |
| 41 | Unstoppable (2010) (Fox) | $89,006,000 | $24,759,000 | $8,253,000 | Nov 12, 2010 |
| 42 | Eat Pray Love (Sony / Columbia) | $87,927,000 | $25,213,000 | $8,404,000 | Aug 13, 2010 |
| 43 | Dear John (Sony / Screen Gems) | $87,317,000 | $33,249,000 | $11,083,000 | Feb 05, 2010 |
| 44 | The A-Team (Fox) | $84,269,000 | $28,012,000 | $9,337,000 | Jun 11, 2010 |
| 45 | Knight and Day (Fox) | $83,397,000 | $21,978,000 | $7,326,000 | Jun 23, 2010 |
| 46 | Dinner for Schmucks (Paramount / DreamWorks) | $79,690,000 | $25,675,000 | $8,558,000 | Jul 30, 2010 |
| 47 | The Tourist (Sony / Columbia) | $73,803,000 | $17,976,000 | $5,992,000 | Dec 10, 2010 |
| 48 | The Bounty Hunter (Sony / Columbia) | $73,181,000 | $22,574,000 | $7,525,000 | Mar 19, 2010 |
| 49 | Diary of a Wimpy Kid (Fox) | $69,844,000 | $24,145,000 | $8,048,000 | Mar 19, 2010 |
| 50 | The Sorcerer's Apprentice (Disney) | $68,914,000 | $19,227,000 | $6,409,000 | Jul 14, 2010 |
| 51 | A Nightmare on Elm Street (2010) (Warner Bros. / New Line) | $68,831,000 | $35,904,000 | $11,968,000 | Apr 30, 2010 |
| 52 | The Last Song (Disney) | $68,695,000 | $17,468,000 | $5,823,000 | Mar 31, 2010 |
| 53 | The Wolfman (Universal) | $67,636,000 | $34,352,000 | $11,451,000 | Feb 12, 2010 |
| 54 | Get Him to the Greek (Universal) | $66,539,000 | $19,174,000 | $6,391,000 | Jun 04, 2010 |
| 55 | Resident Evil: Afterlife (Sony / Screen Gems) | $65,616,000 | $29,082,000 | $9,694,000 | Sep 10, 2010 |
| 56 | Tyler Perry's Why Did I Get Married Too? (Lionsgate) | $65,580,000 | $31,962,000 | $10,654,000 | Apr 02, 2010 |
| 57 | The Tooth Fairy (Fox) | $65,500,000 | $15,289,000 | $5,096,000 | Jan 22, 2010 |
| 58 | Secretariat (Disney) | $65,163,000 | $13,853,000 | $4,618,000 | Oct 08, 2010 |
| 59 | Easy A (Sony / Screen Gems) | $63,731,000 | $19,352,000 | $6,451,000 | Sep 17, 2010 |
| 60 | Takers (Sony / Screen Gems) | $63,014,000 | $22,384,000 | $7,461,000 | Aug 27, 2010 |
| 61 | Legend of the Guardians: The Owls of Ga'Hoole (Warner Bros.) | $60,756,000 | $17,583,000 | $5,861,000 | Sep 24, 2010 |
| 62 | Life As We Know It (Warner Bros.) | $58,245,000 | $15,830,000 | $5,277,000 | Oct 08, 2010 |
| 63 | Letters to Juliet (Summit) | $57,872,000 | $14,776,000 | $4,925,000 | May 14, 2010 |
| 64 | Wall Street: Money Never Sleeps (Fox) | $57,263,000 | $20,746,000 | $6,915,000 | Sep 24, 2010 |
| 65 | Predators (Fox) | $56,746,000 | $27,020,000 | $9,007,000 | Jul 09, 2010 |
| 66 | Hubble 3D (Warner Bros. / IMAX) | $56,429,000 | $448,000 | $149,000 | Mar 19, 2010 |
| 67 | Hot Tub Time Machine (MGM) | $54,877,000 | $15,300,000 | $5,100,000 | Mar 26, 2010 |
| 68 | Kick-Ass (Lionsgate) | $52,458,000 | $21,638,000 | $7,213,000 | Apr 16, 2010 |
| 69 | Killers (2010) (Lionsgate) | $51,354,000 | $17,282,000 | $5,761,000 | Jun 04, 2010 |
| 70 | Saw 3D (Lionsgate) | $49,881,000 | $26,441,000 | $8,814,000 | Oct 29, 2010 |
| 71 | Cop Out (Warner Bros.) | $48,970,000 | $19,873,000 | $6,624,000 | Feb 26, 2010 |
| 72 | Cats & Dogs: The Revenge of Kitty Galore (Warner Bros.) | $47,563,000 | $13,400,000 | $4,467,000 | Jul 30, 2010 |
| 73 | Edge of Darkness (Warner Bros.) | $47,266,000 | $18,785,000 | $6,262,000 | Jan 29, 2010 |
| 74 | Gulliver's Travels (2010) (Fox) | $46,683,000 | $6,883,000 | $2,294,000 | Dec 25, 2010 |
| 75 | Death at a Funeral (2010) (Sony / Screen Gems) | $46,640,000 | $17,697,000 | $5,899,000 | Apr 16, 2010 |
| 76 | Step Up 3D (Disney) | $46,269,000 | $17,255,000 | $5,752,000 | Aug 06, 2010 |
| 77 | The Last Exorcism (Lionsgate) | $44,779,000 | $22,225,000 | $7,408,000 | Aug 27, 2010 |
| 78 | Legion (Sony / Screen Gems) | $43,834,000 | $19,099,000 | $6,366,000 | Jan 22, 2010 |
| 79 | Burlesque (Sony / Screen Gems) | $43,040,000 | $13,038,000 | $4,346,000 | Nov 24, 2010 |
| 80 | The Crazies (Overture) | $42,694,000 | $17,534,000 | $5,845,000 | Feb 26, 2010 |
| 81 | For Colored Girls (Lionsgate) | $41,173,000 | $21,277,000 | $7,092,000 | Nov 05, 2010 |
| 82 | The Back-up Plan (CBS Films) | $40,911,000 | $13,315,000 | $4,438,000 | Apr 23, 2010 |
| 83 | Vampires Suck (Fox) | $40,007,000 | $13,316,000 | $4,439,000 | Aug 18, 2010 |
| 84 | The American (Focus) | $38,856,000 | $14,380,000 | $4,793,000 | Sep 01, 2010 |
| 85 | Green Zone (Universal) | $38,252,000 | $15,615,000 | $5,205,000 | Mar 12, 2010 |
| 86 | Marmaduke (Fox) | $36,715,000 | $12,658,000 | $4,219,000 | Jun 04, 2010 |
| 87 | Devil (Universal) | $36,667,000 | $13,411,000 | $4,470,000 | Sep 17, 2010 |
| 88 | Hereafter (Warner Bros.) | $35,735,000 | $240,000 | $80,000 | Oct 15, 2010 |
| 89 | When in Rome (Disney) | $35,650,000 | $13,477,000 | $4,492,000 | Jan 29, 2010 |
| 90 | Love and Other Drugs (Fox) | $35,321,000 | $10,628,000 | $3,543,000 | Nov 24, 2010 |
| 91 | She's Out of My League (Paramount) | $34,515,000 | $10,667,000 | $3,556,000 | Mar 12, 2010 |
| 92 | Scott Pilgrim vs. the World (Universal) | $34,401,000 | $11,578,000 | $3,859,000 | Aug 13, 2010 |
| 93 | Charlie St. Cloud (Universal) | $34,006,000 | $13,511,000 | $4,504,000 | Jul 30, 2010 |
| 94 | Morning Glory (2010) (Paramount) | $33,842,000 | $10,043,000 | $3,348,000 | Nov 10, 2010 |
| 95 | How Do You Know (Sony / Columbia) | $32,970,000 | $8,168,000 | $2,723,000 | Dec 17, 2010 |
| 96 | Daybreakers (Lionsgate) | $32,848,000 | $16,529,000 | $5,510,000 | Jan 08, 2010 |
| 97 | Nanny McPhee Returns (Universal) | $31,659,000 | $9,175,000 | $3,058,000 | Aug 20, 2010 |
| 98 | The Switch (2010) (Miramax) | $30,314,000 | $9,207,000 | $3,069,000 | Aug 20, 2010 |
| 99 | Brooklyn's Finest (Overture) | $29,642,000 | $14,569,000 | $4,856,000 | Mar 05, 2010 |
| 100 | Machete (Fox) | $29,020,000 | $12,458,000 | $4,153,000 | Sep 03, 2010 |
| 101 | Ramona and Beezus (Fox) | $28,555,000 | $8,523,000 | $2,841,000 | Jul 23, 2010 |
| 102 | Leap Year (2010) (Universal) | $28,284,000 | $10,043,000 | $3,348,000 | Jan 08, 2010 |
| 103 | You Again (Disney) | $28,047,000 | $9,175,000 | $3,058,000 | Sep 24, 2010 |
| 104 | Alpha and Omega (Lionsgate) | $27,398,000 | $9,938,000 | $3,313,000 | Sep 17, 2010 |
| 105 | Piranha 3D (Weinstein Company) | $27,285,000 | $11,029,000 | $3,676,000 | Aug 20, 2010 |
| 106 | Lottery Ticket (Warner Bros.) | $26,976,000 | $11,624,000 | $3,875,000 | Aug 20, 2010 |
| 107 | The Spy Next Door (Lionsgate) | $26,526,000 | $10,614,000 | $3,538,000 | Jan 15, 2010 |
| 108 | From Paris with Love (Lionsgate) | $26,274,000 | $8,903,000 | $2,968,000 | Feb 05, 2010 |
| 109 | The Losers (Warner Bros.) | $25,744,000 | $10,265,000 | $3,422,000 | Apr 23, 2010 |
| 110 | Faster (2010) (CBS Films) | $25,361,000 | $9,301,000 | $3,100,000 | Nov 24, 2010 |
| 111 | Just Wright (Fox Searchlight) | $23,488,000 | $9,041,000 | $3,014,000 | May 14, 2010 |
| 112 | Skyline (Universal / Rogue) | $23,346,000 | $12,759,000 | $4,253,000 | Nov 12, 2010 |
| 113 | The Next Three Days (Lionsgate) | $23,079,000 | $7,140,000 | $2,380,000 | Nov 19, 2010 |
| 114 | The Kids Are All Right (Focus) | $22,711,000 | $537,000 | $179,000 | Jul 09, 2010 |
| 115 | Our Family Wedding (Fox Searchlight) | $22,098,000 | $8,326,000 | $2,775,000 | Mar 12, 2010 |
| 116 | Country Strong (Sony / Screen Gems) | $22,064,000 | $33,000 | $11,000 | Dec 22, 2010 |
| 117 | Oceans (Disneynature) | $21,195,000 | $6,612,000 | $2,204,000 | Apr 22, 2010 |
| 118 | Remember Me (Summit) | $20,808,000 | $8,827,000 | $2,942,000 | Mar 12, 2010 |
| 119 | 127 Hours (Fox Searchlight) | $20,008,000 | $289,000 | $96,000 | Nov 05, 2010 |
| 120 | Going the Distance (2010) (Warner Bros. / New Line) | $19,429,000 | $7,513,000 | $2,504,000 | Sep 03, 2010 |
| 121 | Furry Vengeance (Summit) | $19,239,000 | $7,232,000 | $2,411,000 | Apr 30, 2010 |
| 122 | Splice (Warner Bros) | $18,562,000 | $8,059,000 | $2,686,000 | Jun 04, 2010 |
| 123 | The Ghost Writer (Summit) | $16,960,000 | $200,000 | $67,000 | Feb 19, 2010 |
| 124 | Youth in Revolt (The Weinstein Company) | $16,669,000 | $7,517,000 | $2,506,000 | Jan 08, 2010 |
| 125 | My Soul to Take (Universal / Rogue) | $16,090,000 | $7,467,000 | $2,489,000 | Oct 08, 2010 |
| 126 | Repo Men (Universal) | $15,053,000 | $6,685,000 | $2,228,000 | Mar 19, 2010 |
| 127 | Case 39 (Paramount Vantage) | $14,472,000 | $5,839,000 | $1,946,000 | Oct 01, 2010 |
| 128 | Extraordinary Measures (CBS Films) | $13,622,000 | $6,561,000 | $2,187,000 | Jan 22, 2010 |
| 129 | Let Me In (Relativity / Overture) | $13,242,000 | $5,617,000 | $1,872,000 | Oct 01, 2010 |
| 130 | Jonah Hex (Warner Bros.) | $11,510,000 | $5,870,000 | $1,957,000 | Jun 18, 2010 |
| 131 | The Girl with the Dragon Tattoo (2009) (Music Box) | $11,016,000 | $366,000 | $122,000 | Mar 19, 2010 |
| 132 | Blue Valentine (2010) (Weinstein Company) | $10,592,000 | $211,000 | $70,000 | Dec 29, 2010 |
| 133 | Fair Game (2010) (Summit) | $10,411,000 | $710,000 | $237,000 | Nov 05, 2010 |
| 134 | Get Low (Sony Pictures Classics) | $10,014,000 | $96,000 | $32,000 | Jul 30, 2010 |
| 135 | MacGruber (Universal / Rogue) | $9,304,000 | $4,412,000 | $1,471,000 | May 21, 2010 |
| 136 | The Girl Who Played With Fire (Music Box) | $8,335,000 | $988,000 | $329,000 | Jul 09, 2010 |
| 137 | Cyrus (Fox Searchlight) | $8,136,000 | $198,000 | $66,000 | Jun 18, 2010 |
| 138 | Babies (Focus) | $7,988,000 | $2,359,000 | $786,000 | May 07, 2010 |
| 139 | Conviction (Fox Searchlight) | $7,402,000 | $112,000 | $37,000 | Oct 15, 2010 |
| 140 | City Island (Anchor Bay) | $7,280,000 | $35,000 | $12,000 | Mar 19, 2010 |
| 141 | The Last Station (Sony Pictures Classics) | $7,222,000 | $80,000 | $27,000 | Jan 15, 2010 |
| 142 | Winter's Bone (Roadside Attractions) | $7,128,000 | $93,000 | $31,000 | Jun 11, 2010 |
| 143 | Waiting for 'Superman' (Paramount Vantage) | $7,003,000 | $152,000 | $51,000 | Sep 24, 2010 |
| 144 | The Secret in Their Eyes (2010) (Sony Pictures Classics) | $6,975,000 | $183,000 | $61,000 | Apr 16, 2010 |
| 145 | It's Kind of a Funny Story (Focus) | $6,944,000 | $2,197,000 | $732,000 | Oct 08, 2010 |
| 146 | The Warrior's Way (Relativity Media) | $6,174,000 | $3,327,000 | $1,109,000 | Dec 03, 2010 |
| 147 | The Girl Who Kicked the Hornet's Nest (Music Box) | $5,663,000 | $789,000 | $263,000 | Oct 29, 2010 |
| 148 | Biutiful (Roadside Attractions) | $5,567,000 | $49,000 | $16,000 | Dec 29, 2010 |
| 149 | I Am Love (Magnolia) | $5,462,000 | $133,000 | $44,000 | Jun 18, 2010 |
| 150 | Mao's Last Dancer (Samuel Goldwyn) | $5,257,000 | $218,000 | $73,000 | Aug 20, 2010 |
