| 1 | Toy Story 3 (Disney) | $487,591,000 | $129,600,000 | $43,200,000 | Jun 18, 2010 |
| 2 | Alice in Wonderland (2010) (Disney) | $392,643,000 | $136,408,000 | $45,469,000 | Mar 05, 2010 |
| 3 | Iron Man 2 (Paramount) | $366,721,000 | $150,532,000 | $50,177,000 | May 07, 2010 |
| 4 | The Twilight Saga: Eclipse (Summit) | $353,096,000 | $76,172,000 | $25,391,000 | Jun 30, 2010 |
| 5 | Harry Potter and the Deathly Hallows: Part 1 (Warner Bros.) | $347,752,000 | $146,884,000 | $48,961,000 | Nov 19, 2010 |
| 6 | Inception (Warner Bros.) | $343,749,000 | $73,767,000 | $24,589,000 | Jul 16, 2010 |
| 7 | Despicable Me (Universal) | $295,505,000 | $66,261,000 | $22,087,000 | Jul 09, 2010 |
| 8 | Shrek Forever After (Paramount / DreamWorks) | $280,093,000 | $83,228,000 | $27,743,000 | May 21, 2010 |
| 9 | How to Train Your Dragon (Paramount / DreamWorks) | $255,637,000 | $51,381,000 | $17,127,000 | Mar 26, 2010 |
| 10 | Tangled (Disney) | $235,947,000 | $57,297,000 | $19,099,000 | Nov 24, 2010 |
| 11 | The Karate Kid (2010) (Sony / Columbia) | $207,478,000 | $65,402,000 | $21,801,000 | Jun 11, 2010 |
| 12 | TRON: Legacy (Disney) | $202,157,000 | $51,727,000 | $17,242,000 | Dec 17, 2010 |
| 13 | True Grit (2010) (Paramount) | $200,968,000 | $29,173,000 | $9,724,000 | Dec 22, 2010 |
| 14 | Clash of the Titans (2010) (Warner Bros.) | $191,762,000 | $71,945,000 | $23,982,000 | Apr 02, 2010 |
| 15 | Grown Ups (Sony / Columbia) | $190,336,000 | $47,591,000 | $15,864,000 | Jun 25, 2010 |
| 16 | Little Fockers (Universal) | $174,401,000 | $36,227,000 | $12,076,000 | Dec 22, 2010 |
| 17 | Megamind (Paramount / DreamWorks) | $174,375,000 | $54,065,000 | $18,022,000 | Nov 05, 2010 |
| 18 | The King's Speech (Weinstein Company) | $163,074,000 | $418,000 | $139,000 | Nov 26, 2010 |
| 19 | The Last Airbender (Paramount) | $154,619,000 | $47,378,000 | $15,793,000 | Jul 01, 2010 |
| 20 | Shutter Island (Paramount) | $150,403,000 | $48,244,000 | $16,081,000 | Feb 19, 2010 |
| 21 | The Other Guys (Sony / Columbia) | $140,072,000 | $41,760,000 | $13,920,000 | Aug 06, 2010 |
| 22 | Salt (Sony / Columbia) | $139,005,000 | $42,310,000 | $14,103,000 | Jul 23, 2010 |
| 23 | Jackass 3D (Paramount) | $137,734,000 | $59,161,000 | $19,720,000 | Oct 15, 2010 |
| 24 | Valentine's Day (Warner Bros. / New Line) | $129,811,000 | $66,101,000 | $22,034,000 | Feb 12, 2010 |
| 25 | Black Swan (Fox Searchlight) | $125,662,000 | $1,696,000 | $565,000 | Dec 03, 2010 |
| 26 | Robin Hood (2010) (Universal) | $123,682,000 | $42,371,000 | $14,124,000 | May 14, 2010 |
| 27 | The Chronicles of Narnia: The Voyage of the Dawn Treader (Fox) | $122,645,000 | $28,204,000 | $9,401,000 | Dec 10, 2010 |
| 28 | The Expendables (Lionsgate) | $121,096,000 | $40,916,000 | $13,639,000 | Aug 13, 2010 |
| 29 | Due Date (Warner Bros.) | $118,124,000 | $38,407,000 | $12,802,000 | Nov 05, 2010 |
| 30 | Yogi Bear (Warner Bros.) | $117,780,000 | $19,282,000 | $6,427,000 | Dec 17, 2010 |
| 31 | Date Night (Fox) | $115,977,000 | $29,617,000 | $9,872,000 | Apr 09, 2010 |
| 32 | The Social Network (Sony / Columbia) | $113,922,000 | $26,372,000 | $8,791,000 | Oct 01, 2010 |
| 33 | Sex and the City 2 (Warner Bros. / New Line) | $112,024,000 | $36,424,000 | $12,141,000 | May 27, 2010 |
| 34 | The Book of Eli (Warner Bros.) | $111,422,000 | $38,525,000 | $12,842,000 | Jan 15, 2010 |
| 35 | The Fighter (Paramount) | $109,991,000 | $352,000 | $117,000 | Dec 10, 2010 |
| 36 | The Town (Warner Bros.) | $108,310,000 | $27,972,000 | $9,324,000 | Sep 17, 2010 |
| 37 | Prince of Persia: The Sands of Time (Disney) | $106,634,000 | $35,359,000 | $11,786,000 | May 28, 2010 |
| 38 | Red (2010) (Summit) | $106,188,000 | $25,568,000 | $8,523,000 | Oct 15, 2010 |
| 39 | Percy Jackson and the Olympians: The Lightning Thief (Fox) | $104,287,000 | $36,699,000 | $12,233,000 | Feb 12, 2010 |
| 40 | Paranormal Activity 2 (Paramount) | $99,577,000 | $47,793,000 | $15,931,000 | Oct 22, 2010 |
| 41 | Unstoppable (2010) (Fox) | $95,829,000 | $26,657,000 | $8,886,000 | Nov 12, 2010 |
| 42 | Eat Pray Love (Sony / Columbia) | $94,667,000 | $27,146,000 | $9,049,000 | Aug 13, 2010 |
| 43 | Dear John (Sony / Screen Gems) | $94,010,000 | $35,798,000 | $11,933,000 | Feb 05, 2010 |
| 44 | The A-Team (Fox) | $90,729,000 | $30,159,000 | $10,053,000 | Jun 11, 2010 |
| 45 | Knight and Day (Fox) | $89,790,000 | $23,663,000 | $7,888,000 | Jun 23, 2010 |
| 46 | Dinner for Schmucks (Paramount / DreamWorks) | $85,799,000 | $27,643,000 | $9,214,000 | Jul 30, 2010 |
| 47 | The Tourist (Sony / Columbia) | $79,460,000 | $19,354,000 | $6,451,000 | Dec 10, 2010 |
| 48 | The Bounty Hunter (Sony / Columbia) | $78,791,000 | $24,305,000 | $8,102,000 | Mar 19, 2010 |
| 49 | Diary of a Wimpy Kid (Fox) | $75,198,000 | $25,996,000 | $8,665,000 | Mar 19, 2010 |
| 50 | The Sorcerer's Apprentice (Disney) | $74,196,000 | $20,701,000 | $6,900,000 | Jul 14, 2010 |
| 51 | A Nightmare on Elm Street (2010) (Warner Bros. / New Line) | $74,107,000 | $38,657,000 | $12,886,000 | Apr 30, 2010 |
| 52 | The Last Song (Disney) | $73,961,000 | $18,807,000 | $6,269,000 | Mar 31, 2010 |
| 53 | The Wolfman (Universal) | $72,820,000 | $36,985,000 | $12,328,000 | Feb 12, 2010 |
| 54 | Get Him to the Greek (Universal) | $71,639,000 | $20,644,000 | $6,881,000 | Jun 04, 2010 |
| 55 | Resident Evil: Afterlife (Sony / Screen Gems) | $70,645,000 | $31,312,000 | $10,437,000 | Sep 10, 2010 |
| 56 | Tyler Perry's Why Did I Get Married Too? (Lionsgate) | $70,607,000 | $34,412,000 | $11,471,000 | Apr 02, 2010 |
| 57 | The Tooth Fairy (Fox) | $70,520,000 | $16,461,000 | $5,487,000 | Jan 22, 2010 |
| 58 | Secretariat (Disney) | $70,158,000 | $14,915,000 | $4,972,000 | Oct 08, 2010 |
| 59 | Easy A (Sony / Screen Gems) | $68,616,000 | $20,836,000 | $6,945,000 | Sep 17, 2010 |
| 60 | Takers (Sony / Screen Gems) | $67,845,000 | $24,100,000 | $8,033,000 | Aug 27, 2010 |
| 61 | Legend of the Guardians: The Owls of Ga'Hoole (Warner Bros.) | $65,413,000 | $18,930,000 | $6,310,000 | Sep 24, 2010 |
| 62 | Life As We Know It (Warner Bros.) | $62,710,000 | $17,044,000 | $5,681,000 | Oct 08, 2010 |
| 63 | Letters to Juliet (Summit) | $62,308,000 | $15,909,000 | $5,303,000 | May 14, 2010 |
| 64 | Wall Street: Money Never Sleeps (Fox) | $61,653,000 | $22,336,000 | $7,445,000 | Sep 24, 2010 |
| 65 | Predators (Fox) | $61,096,000 | $29,092,000 | $9,697,000 | Jul 09, 2010 |
| 66 | Hubble 3D (Warner Bros. / IMAX) | $60,951,000 | $483,000 | $161,000 | Mar 19, 2010 |
| 67 | Hot Tub Time Machine (MGM) | $59,084,000 | $16,473,000 | $5,491,000 | Mar 26, 2010 |
| 68 | Kick-Ass (Lionsgate) | $56,479,000 | $23,297,000 | $7,766,000 | Apr 16, 2010 |
| 69 | Killers (2010) (Lionsgate) | $55,291,000 | $18,607,000 | $6,202,000 | Jun 04, 2010 |
| 70 | Saw 3D (Lionsgate) | $53,705,000 | $28,468,000 | $9,489,000 | Oct 29, 2010 |
| 71 | Cop Out (Warner Bros.) | $52,724,000 | $21,396,000 | $7,132,000 | Feb 26, 2010 |
| 72 | Cats & Dogs: The Revenge of Kitty Galore (Warner Bros.) | $51,209,000 | $14,427,000 | $4,809,000 | Jul 30, 2010 |
| 73 | Edge of Darkness (Warner Bros.) | $50,889,000 | $20,225,000 | $6,742,000 | Jan 29, 2010 |
| 74 | Gulliver's Travels (2010) (Fox) | $50,262,000 | $7,411,000 | $2,470,000 | Dec 25, 2010 |
| 75 | Death at a Funeral (2010) (Sony / Screen Gems) | $50,215,000 | $19,054,000 | $6,351,000 | Apr 16, 2010 |
| 76 | Step Up 3D (Disney) | $49,816,000 | $18,578,000 | $6,193,000 | Aug 06, 2010 |
| 77 | The Last Exorcism (Lionsgate) | $48,211,000 | $23,929,000 | $7,976,000 | Aug 27, 2010 |
| 78 | Legion (Sony / Screen Gems) | $47,194,000 | $20,563,000 | $6,854,000 | Jan 22, 2010 |
| 79 | Burlesque (Sony / Screen Gems) | $46,339,000 | $14,037,000 | $4,679,000 | Nov 24, 2010 |
| 80 | The Crazies (Overture) | $45,966,000 | $18,878,000 | $6,293,000 | Feb 26, 2010 |
| 81 | For Colored Girls (Lionsgate) | $44,329,000 | $22,908,000 | $7,636,000 | Nov 05, 2010 |
| 82 | The Back-up Plan (CBS Films) | $44,047,000 | $14,336,000 | $4,779,000 | Apr 23, 2010 |
| 83 | Vampires Suck (Fox) | $43,074,000 | $14,337,000 | $4,779,000 | Aug 18, 2010 |
| 84 | The American (Focus) | $41,834,000 | $15,483,000 | $5,161,000 | Sep 01, 2010 |
| 85 | Green Zone (Universal) | $41,185,000 | $16,812,000 | $5,604,000 | Mar 12, 2010 |
| 86 | Marmaduke (Fox) | $39,529,000 | $13,628,000 | $4,543,000 | Jun 04, 2010 |
| 87 | Devil (Universal) | $39,478,000 | $14,439,000 | $4,813,000 | Sep 17, 2010 |
| 88 | Hereafter (Warner Bros.) | $38,475,000 | $259,000 | $86,000 | Oct 15, 2010 |
| 89 | When in Rome (Disney) | $38,383,000 | $14,510,000 | $4,837,000 | Jan 29, 2010 |
| 90 | Love and Other Drugs (Fox) | $38,028,000 | $11,443,000 | $3,814,000 | Nov 24, 2010 |
| 91 | She's Out of My League (Paramount) | $37,160,000 | $11,485,000 | $3,828,000 | Mar 12, 2010 |
| 92 | Scott Pilgrim vs. the World (Universal) | $37,038,000 | $12,466,000 | $4,155,000 | Aug 13, 2010 |
| 93 | Charlie St. Cloud (Universal) | $36,613,000 | $14,547,000 | $4,849,000 | Jul 30, 2010 |
| 94 | Morning Glory (2010) (Paramount) | $36,436,000 | $10,813,000 | $3,604,000 | Nov 10, 2010 |
| 95 | How Do You Know (Sony / Columbia) | $35,497,000 | $8,794,000 | $2,931,000 | Dec 17, 2010 |
| 96 | Daybreakers (Lionsgate) | $35,366,000 | $17,796,000 | $5,932,000 | Jan 08, 2010 |
| 97 | Nanny McPhee Returns (Universal) | $34,085,000 | $9,878,000 | $3,293,000 | Aug 20, 2010 |
| 98 | The Switch (2010) (Miramax) | $32,638,000 | $9,912,000 | $3,304,000 | Aug 20, 2010 |
| 99 | Brooklyn's Finest (Overture) | $31,915,000 | $15,685,000 | $5,228,000 | Mar 05, 2010 |
| 100 | Machete (Fox) | $31,245,000 | $13,413,000 | $4,471,000 | Sep 03, 2010 |
| 101 | Ramona and Beezus (Fox) | $30,744,000 | $9,177,000 | $3,059,000 | Jul 23, 2010 |
| 102 | Leap Year (2010) (Universal) | $30,452,000 | $10,812,000 | $3,604,000 | Jan 08, 2010 |
| 103 | You Again (Disney) | $30,197,000 | $9,878,000 | $3,293,000 | Sep 24, 2010 |
| 104 | Alpha and Omega (Lionsgate) | $29,499,000 | $10,700,000 | $3,567,000 | Sep 17, 2010 |
| 105 | Piranha 3D (Weinstein Company) | $29,376,000 | $11,875,000 | $3,958,000 | Aug 20, 2010 |
| 106 | Lottery Ticket (Warner Bros.) | $29,044,000 | $12,515,000 | $4,172,000 | Aug 20, 2010 |
| 107 | The Spy Next Door (Lionsgate) | $28,559,000 | $11,427,000 | $3,809,000 | Jan 15, 2010 |
| 108 | From Paris with Love (Lionsgate) | $28,288,000 | $9,586,000 | $3,195,000 | Feb 05, 2010 |
| 109 | The Losers (Warner Bros.) | $27,718,000 | $11,052,000 | $3,684,000 | Apr 23, 2010 |
| 110 | Faster (2010) (CBS Films) | $27,305,000 | $10,014,000 | $3,338,000 | Nov 24, 2010 |
| 111 | Just Wright (Fox Searchlight) | $25,289,000 | $9,734,000 | $3,245,000 | May 14, 2010 |
| 112 | Skyline (Universal / Rogue) | $25,135,000 | $13,737,000 | $4,579,000 | Nov 12, 2010 |
| 113 | The Next Three Days (Lionsgate) | $24,848,000 | $7,687,000 | $2,562,000 | Nov 19, 2010 |
| 114 | The Kids Are All Right (Focus) | $24,451,000 | $578,000 | $193,000 | Jul 09, 2010 |
| 115 | Our Family Wedding (Fox Searchlight) | $23,792,000 | $8,964,000 | $2,988,000 | Mar 12, 2010 |
| 116 | Country Strong (Sony / Screen Gems) | $23,755,000 | $36,000 | $12,000 | Dec 22, 2010 |
| 117 | Oceans (Disneynature) | $22,819,000 | $7,119,000 | $2,373,000 | Apr 22, 2010 |
| 118 | Remember Me (Summit) | $22,403,000 | $9,504,000 | $3,168,000 | Mar 12, 2010 |
| 119 | 127 Hours (Fox Searchlight) | $21,542,000 | $311,000 | $104,000 | Nov 05, 2010 |
| 120 | Going the Distance (2010) (Warner Bros. / New Line) | $20,918,000 | $8,089,000 | $2,696,000 | Sep 03, 2010 |
| 121 | Furry Vengeance (Summit) | $20,714,000 | $7,787,000 | $2,596,000 | Apr 30, 2010 |
| 122 | Splice (Warner Bros) | $19,985,000 | $8,677,000 | $2,892,000 | Jun 04, 2010 |
| 123 | The Ghost Writer (Summit) | $18,260,000 | $215,000 | $72,000 | Feb 19, 2010 |
| 124 | Youth in Revolt (The Weinstein Company) | $17,947,000 | $8,093,000 | $2,698,000 | Jan 08, 2010 |
| 125 | My Soul to Take (Universal / Rogue) | $17,323,000 | $8,039,000 | $2,680,000 | Oct 08, 2010 |
| 126 | Repo Men (Universal) | $16,207,000 | $7,198,000 | $2,399,000 | Mar 19, 2010 |
| 127 | Case 39 (Paramount Vantage) | $15,581,000 | $6,286,000 | $2,095,000 | Oct 01, 2010 |
| 128 | Extraordinary Measures (CBS Films) | $14,666,000 | $7,064,000 | $2,355,000 | Jan 22, 2010 |
| 129 | Let Me In (Relativity / Overture) | $14,257,000 | $6,048,000 | $2,016,000 | Oct 01, 2010 |
| 130 | Jonah Hex (Warner Bros.) | $12,392,000 | $6,320,000 | $2,107,000 | Jun 18, 2010 |
| 131 | The Girl with the Dragon Tattoo (2009) (Music Box) | $11,861,000 | $394,000 | $131,000 | Mar 19, 2010 |
| 132 | Blue Valentine (2010) (Weinstein Company) | $11,404,000 | $228,000 | $76,000 | Dec 29, 2010 |
| 133 | Fair Game (2010) (Summit) | $11,209,000 | $765,000 | $255,000 | Nov 05, 2010 |
| 134 | Get Low (Sony Pictures Classics) | $10,782,000 | $104,000 | $35,000 | Jul 30, 2010 |
| 135 | MacGruber (Universal / Rogue) | $10,017,000 | $4,750,000 | $1,583,000 | May 21, 2010 |
| 136 | The Girl Who Played With Fire (Music Box) | $8,974,000 | $1,063,000 | $354,000 | Jul 09, 2010 |
| 137 | Cyrus (Fox Searchlight) | $8,759,000 | $213,000 | $71,000 | Jun 18, 2010 |
| 138 | Babies (Focus) | $8,601,000 | $2,540,000 | $847,000 | May 07, 2010 |
| 139 | Conviction (Fox Searchlight) | $7,970,000 | $120,000 | $40,000 | Oct 15, 2010 |
| 140 | City Island (Anchor Bay) | $7,838,000 | $38,000 | $13,000 | Mar 19, 2010 |
| 141 | The Last Station (Sony Pictures Classics) | $7,775,000 | $87,000 | $29,000 | Jan 15, 2010 |
| 142 | Winter's Bone (Roadside Attractions) | $7,674,000 | $100,000 | $33,000 | Jun 11, 2010 |
| 143 | Waiting for 'Superman' (Paramount Vantage) | $7,540,000 | $163,000 | $54,000 | Sep 24, 2010 |
| 144 | The Secret in Their Eyes (2010) (Sony Pictures Classics) | $7,509,000 | $197,000 | $66,000 | Apr 16, 2010 |
| 145 | It's Kind of a Funny Story (Focus) | $7,477,000 | $2,366,000 | $789,000 | Oct 08, 2010 |
| 146 | The Warrior's Way (Relativity Media) | $6,647,000 | $3,582,000 | $1,194,000 | Dec 03, 2010 |
| 147 | The Girl Who Kicked the Hornet's Nest (Music Box) | $6,097,000 | $850,000 | $283,000 | Oct 29, 2010 |
| 148 | Biutiful (Roadside Attractions) | $5,993,000 | $53,000 | $18,000 | Dec 29, 2010 |
| 149 | I Am Love (Magnolia) | $5,881,000 | $143,000 | $48,000 | Jun 18, 2010 |
| 150 | Mao's Last Dancer (Samuel Goldwyn) | $5,660,000 | $235,000 | $78,000 | Aug 20, 2010 |
| 151 | Solitary Man (Anchor Bay) | $5,123,000 | $112,000 | $37,000 | May 21, 2010 |
| 152 | Inside Job (Sony Pictures Classics) | $5,067,000 | $47,000 | $16,000 | Oct 08, 2010 |
