| 1 | Toy Story 3 (Disney) | $474,968,000 | $126,245,000 | $42,082,000 | Jun 18, 2010 |
| 2 | Alice in Wonderland (2010) (Disney) | $382,477,000 | $132,876,000 | $44,292,000 | Mar 05, 2010 |
| 3 | Iron Man 2 (Paramount) | $357,227,000 | $146,634,000 | $48,878,000 | May 07, 2010 |
| 4 | The Twilight Saga: Eclipse (Summit) | $343,955,000 | $74,200,000 | $24,733,000 | Jun 30, 2010 |
| 5 | Harry Potter and the Deathly Hallows: Part 1 (Warner Bros.) | $338,749,000 | $143,081,000 | $47,694,000 | Nov 19, 2010 |
| 6 | Inception (Warner Bros.) | $334,850,000 | $71,857,000 | $23,952,000 | Jul 16, 2010 |
| 7 | Despicable Me (Universal) | $287,854,000 | $64,546,000 | $21,515,000 | Jul 09, 2010 |
| 8 | Shrek Forever After (Paramount / DreamWorks) | $272,841,000 | $81,073,000 | $27,024,000 | May 21, 2010 |
| 9 | How to Train Your Dragon (Paramount / DreamWorks) | $249,019,000 | $50,051,000 | $16,684,000 | Mar 26, 2010 |
| 10 | Tangled (Disney) | $229,838,000 | $55,813,000 | $18,604,000 | Nov 24, 2010 |
| 11 | The Karate Kid (2010) (Sony / Columbia) | $202,107,000 | $63,709,000 | $21,236,000 | Jun 11, 2010 |
| 12 | TRON: Legacy (Disney) | $196,924,000 | $50,387,000 | $16,796,000 | Dec 17, 2010 |
| 13 | True Grit (2010) (Paramount) | $195,765,000 | $28,418,000 | $9,473,000 | Dec 22, 2010 |
| 14 | Clash of the Titans (2010) (Warner Bros.) | $186,797,000 | $70,083,000 | $23,361,000 | Apr 02, 2010 |
| 15 | Grown Ups (Sony / Columbia) | $185,408,000 | $46,359,000 | $15,453,000 | Jun 25, 2010 |
| 16 | Little Fockers (Universal) | $169,886,000 | $35,289,000 | $11,763,000 | Dec 22, 2010 |
| 17 | Megamind (Paramount / DreamWorks) | $169,860,000 | $52,666,000 | $17,555,000 | Nov 05, 2010 |
| 18 | The King's Speech (Weinstein Company) | $158,852,000 | $407,000 | $136,000 | Nov 26, 2010 |
| 19 | The Last Airbender (Paramount) | $150,616,000 | $46,151,000 | $15,384,000 | Jul 01, 2010 |
| 20 | Shutter Island (Paramount) | $146,509,000 | $46,995,000 | $15,665,000 | Feb 19, 2010 |
| 21 | The Other Guys (Sony / Columbia) | $136,446,000 | $40,679,000 | $13,560,000 | Aug 06, 2010 |
| 22 | Salt (Sony / Columbia) | $135,406,000 | $41,214,000 | $13,738,000 | Jul 23, 2010 |
| 23 | Jackass 3D (Paramount) | $134,168,000 | $57,629,000 | $19,210,000 | Oct 15, 2010 |
| 24 | Valentine's Day (Warner Bros. / New Line) | $126,450,000 | $64,390,000 | $21,463,000 | Feb 12, 2010 |
| 25 | Black Swan (Fox Searchlight) | $122,408,000 | $1,652,000 | $551,000 | Dec 03, 2010 |
| 26 | Robin Hood (2010) (Universal) | $120,480,000 | $41,274,000 | $13,758,000 | May 14, 2010 |
| 27 | The Chronicles of Narnia: The Voyage of the Dawn Treader (Fox) | $119,469,000 | $27,473,000 | $9,158,000 | Dec 10, 2010 |
| 28 | The Expendables (Lionsgate) | $117,961,000 | $39,857,000 | $13,286,000 | Aug 13, 2010 |
| 29 | Due Date (Warner Bros.) | $115,066,000 | $37,413,000 | $12,471,000 | Nov 05, 2010 |
| 30 | Yogi Bear (Warner Bros.) | $114,730,000 | $18,783,000 | $6,261,000 | Dec 17, 2010 |
| 31 | Date Night (Fox) | $112,974,000 | $28,850,000 | $9,617,000 | Apr 09, 2010 |
| 32 | The Social Network (Sony / Columbia) | $110,973,000 | $25,689,000 | $8,563,000 | Oct 01, 2010 |
| 33 | Sex and the City 2 (Warner Bros. / New Line) | $109,124,000 | $35,481,000 | $11,827,000 | May 27, 2010 |
| 34 | The Book of Eli (Warner Bros.) | $108,537,000 | $37,527,000 | $12,509,000 | Jan 15, 2010 |
| 35 | The Fighter (Paramount) | $107,143,000 | $343,000 | $114,000 | Dec 10, 2010 |
| 36 | The Town (Warner Bros.) | $105,506,000 | $27,248,000 | $9,083,000 | Sep 17, 2010 |
| 37 | Prince of Persia: The Sands of Time (Disney) | $103,873,000 | $34,444,000 | $11,481,000 | May 28, 2010 |
| 38 | Red (2010) (Summit) | $103,439,000 | $24,906,000 | $8,302,000 | Oct 15, 2010 |
| 39 | Percy Jackson and the Olympians: The Lightning Thief (Fox) | $101,587,000 | $35,749,000 | $11,916,000 | Feb 12, 2010 |
| 40 | Paranormal Activity 2 (Paramount) | $96,999,000 | $46,556,000 | $15,519,000 | Oct 22, 2010 |
| 41 | Unstoppable (2010) (Fox) | $93,348,000 | $25,967,000 | $8,656,000 | Nov 12, 2010 |
| 42 | Eat Pray Love (Sony / Columbia) | $92,216,000 | $26,443,000 | $8,814,000 | Aug 13, 2010 |
| 43 | Dear John (Sony / Screen Gems) | $91,576,000 | $34,871,000 | $11,624,000 | Feb 05, 2010 |
| 44 | The A-Team (Fox) | $88,380,000 | $29,378,000 | $9,793,000 | Jun 11, 2010 |
| 45 | Knight and Day (Fox) | $87,465,000 | $23,050,000 | $7,683,000 | Jun 23, 2010 |
| 46 | Dinner for Schmucks (Paramount / DreamWorks) | $83,578,000 | $26,927,000 | $8,976,000 | Jul 30, 2010 |
| 47 | The Tourist (Sony / Columbia) | $77,403,000 | $18,853,000 | $6,284,000 | Dec 10, 2010 |
| 48 | The Bounty Hunter (Sony / Columbia) | $76,751,000 | $23,675,000 | $7,892,000 | Mar 19, 2010 |
| 49 | Diary of a Wimpy Kid (Fox) | $73,251,000 | $25,323,000 | $8,441,000 | Mar 19, 2010 |
| 50 | The Sorcerer's Apprentice (Disney) | $72,275,000 | $20,165,000 | $6,722,000 | Jul 14, 2010 |
| 51 | A Nightmare on Elm Street (2010) (Warner Bros. / New Line) | $72,189,000 | $37,656,000 | $12,552,000 | Apr 30, 2010 |
| 52 | The Last Song (Disney) | $72,046,000 | $18,320,000 | $6,107,000 | Mar 31, 2010 |
| 53 | The Wolfman (Universal) | $70,935,000 | $36,028,000 | $12,009,000 | Feb 12, 2010 |
| 54 | Get Him to the Greek (Universal) | $69,784,000 | $20,110,000 | $6,703,000 | Jun 04, 2010 |
| 55 | Resident Evil: Afterlife (Sony / Screen Gems) | $68,816,000 | $30,501,000 | $10,167,000 | Sep 10, 2010 |
| 56 | Tyler Perry's Why Did I Get Married Too? (Lionsgate) | $68,779,000 | $33,521,000 | $11,174,000 | Apr 02, 2010 |
| 57 | The Tooth Fairy (Fox) | $68,695,000 | $16,035,000 | $5,345,000 | Jan 22, 2010 |
| 58 | Secretariat (Disney) | $68,342,000 | $14,529,000 | $4,843,000 | Oct 08, 2010 |
| 59 | Easy A (Sony / Screen Gems) | $66,840,000 | $20,296,000 | $6,765,000 | Sep 17, 2010 |
| 60 | Takers (Sony / Screen Gems) | $66,088,000 | $23,476,000 | $7,825,000 | Aug 27, 2010 |
| 61 | Legend of the Guardians: The Owls of Ga'Hoole (Warner Bros.) | $63,720,000 | $18,440,000 | $6,147,000 | Sep 24, 2010 |
| 62 | Life As We Know It (Warner Bros.) | $61,087,000 | $16,602,000 | $5,534,000 | Oct 08, 2010 |
| 63 | Letters to Juliet (Summit) | $60,695,000 | $15,497,000 | $5,166,000 | May 14, 2010 |
| 64 | Wall Street: Money Never Sleeps (Fox) | $60,056,000 | $21,758,000 | $7,253,000 | Sep 24, 2010 |
| 65 | Predators (Fox) | $59,514,000 | $28,338,000 | $9,446,000 | Jul 09, 2010 |
| 66 | Hubble 3D (Warner Bros. / IMAX) | $59,373,000 | $470,000 | $157,000 | Mar 19, 2010 |
| 67 | Hot Tub Time Machine (MGM) | $57,554,000 | $16,046,000 | $5,349,000 | Mar 26, 2010 |
| 68 | Kick-Ass (Lionsgate) | $55,017,000 | $22,694,000 | $7,565,000 | Apr 16, 2010 |
| 69 | Killers (2010) (Lionsgate) | $53,860,000 | $18,126,000 | $6,042,000 | Jun 04, 2010 |
| 70 | Saw 3D (Lionsgate) | $52,315,000 | $27,731,000 | $9,244,000 | Oct 29, 2010 |
| 71 | Cop Out (Warner Bros.) | $51,359,000 | $20,842,000 | $6,947,000 | Feb 26, 2010 |
| 72 | Cats & Dogs: The Revenge of Kitty Galore (Warner Bros.) | $49,883,000 | $14,054,000 | $4,685,000 | Jul 30, 2010 |
| 73 | Edge of Darkness (Warner Bros.) | $49,571,000 | $19,702,000 | $6,567,000 | Jan 29, 2010 |
| 74 | Gulliver's Travels (2010) (Fox) | $48,960,000 | $7,219,000 | $2,406,000 | Dec 25, 2010 |
| 75 | Death at a Funeral (2010) (Sony / Screen Gems) | $48,915,000 | $18,561,000 | $6,187,000 | Apr 16, 2010 |
| 76 | Step Up 3D (Disney) | $48,526,000 | $18,097,000 | $6,032,000 | Aug 06, 2010 |
| 77 | The Last Exorcism (Lionsgate) | $46,963,000 | $23,309,000 | $7,770,000 | Aug 27, 2010 |
| 78 | Legion (Sony / Screen Gems) | $45,972,000 | $20,030,000 | $6,677,000 | Jan 22, 2010 |
| 79 | Burlesque (Sony / Screen Gems) | $45,139,000 | $13,674,000 | $4,558,000 | Nov 24, 2010 |
| 80 | The Crazies (Overture) | $44,776,000 | $18,389,000 | $6,130,000 | Feb 26, 2010 |
| 81 | For Colored Girls (Lionsgate) | $43,181,000 | $22,314,000 | $7,438,000 | Nov 05, 2010 |
| 82 | The Back-up Plan (CBS Films) | $42,907,000 | $13,965,000 | $4,655,000 | Apr 23, 2010 |
| 83 | Vampires Suck (Fox) | $41,959,000 | $13,966,000 | $4,655,000 | Aug 18, 2010 |
| 84 | The American (Focus) | $40,751,000 | $15,082,000 | $5,027,000 | Sep 01, 2010 |
| 85 | Green Zone (Universal) | $40,118,000 | $16,377,000 | $5,459,000 | Mar 12, 2010 |
| 86 | Marmaduke (Fox) | $38,506,000 | $13,276,000 | $4,425,000 | Jun 04, 2010 |
| 87 | Devil (Universal) | $38,456,000 | $14,065,000 | $4,688,000 | Sep 17, 2010 |
| 88 | Hereafter (Warner Bros.) | $37,478,000 | $252,000 | $84,000 | Oct 15, 2010 |
| 89 | When in Rome (Disney) | $37,389,000 | $14,134,000 | $4,711,000 | Jan 29, 2010 |
| 90 | Love and Other Drugs (Fox) | $37,044,000 | $11,146,000 | $3,715,000 | Nov 24, 2010 |
| 91 | She's Out of My League (Paramount) | $36,198,000 | $11,188,000 | $3,729,000 | Mar 12, 2010 |
| 92 | Scott Pilgrim vs. the World (Universal) | $36,079,000 | $12,143,000 | $4,048,000 | Aug 13, 2010 |
| 93 | Charlie St. Cloud (Universal) | $35,665,000 | $14,171,000 | $4,724,000 | Jul 30, 2010 |
| 94 | Morning Glory (2010) (Paramount) | $35,493,000 | $10,533,000 | $3,511,000 | Nov 10, 2010 |
| 95 | How Do You Know (Sony / Columbia) | $34,578,000 | $8,566,000 | $2,855,000 | Dec 17, 2010 |
| 96 | Daybreakers (Lionsgate) | $34,450,000 | $17,335,000 | $5,778,000 | Jan 08, 2010 |
| 97 | Nanny McPhee Returns (Universal) | $33,203,000 | $9,622,000 | $3,207,000 | Aug 20, 2010 |
| 98 | The Switch (2010) (Miramax) | $31,793,000 | $9,656,000 | $3,219,000 | Aug 20, 2010 |
| 99 | Brooklyn's Finest (Overture) | $31,088,000 | $15,279,000 | $5,093,000 | Mar 05, 2010 |
| 100 | Machete (Fox) | $30,436,000 | $13,066,000 | $4,355,000 | Sep 03, 2010 |
| 101 | Ramona and Beezus (Fox) | $29,948,000 | $8,939,000 | $2,980,000 | Jul 23, 2010 |
| 102 | Leap Year (2010) (Universal) | $29,664,000 | $10,532,000 | $3,511,000 | Jan 08, 2010 |
| 103 | You Again (Disney) | $29,416,000 | $9,622,000 | $3,207,000 | Sep 24, 2010 |
| 104 | Alpha and Omega (Lionsgate) | $28,735,000 | $10,423,000 | $3,474,000 | Sep 17, 2010 |
| 105 | Piranha 3D (Weinstein Company) | $28,616,000 | $11,567,000 | $3,856,000 | Aug 20, 2010 |
| 106 | Lottery Ticket (Warner Bros.) | $28,292,000 | $12,191,000 | $4,064,000 | Aug 20, 2010 |
| 107 | The Spy Next Door (Lionsgate) | $27,820,000 | $11,131,000 | $3,710,000 | Jan 15, 2010 |
| 108 | From Paris with Love (Lionsgate) | $27,556,000 | $9,338,000 | $3,113,000 | Feb 05, 2010 |
| 109 | The Losers (Warner Bros.) | $27,000,000 | $10,765,000 | $3,588,000 | Apr 23, 2010 |
| 110 | Faster (2010) (CBS Films) | $26,598,000 | $9,755,000 | $3,252,000 | Nov 24, 2010 |
| 111 | Just Wright (Fox Searchlight) | $24,634,000 | $9,482,000 | $3,161,000 | May 14, 2010 |
| 112 | Skyline (Universal / Rogue) | $24,485,000 | $13,382,000 | $4,461,000 | Nov 12, 2010 |
| 113 | The Next Three Days (Lionsgate) | $24,204,000 | $7,488,000 | $2,496,000 | Nov 19, 2010 |
| 114 | The Kids Are All Right (Focus) | $23,818,000 | $563,000 | $188,000 | Jul 09, 2010 |
| 115 | Our Family Wedding (Fox Searchlight) | $23,176,000 | $8,732,000 | $2,911,000 | Mar 12, 2010 |
| 116 | Country Strong (Sony / Screen Gems) | $23,140,000 | $35,000 | $12,000 | Dec 22, 2010 |
| 117 | Oceans (Disneynature) | $22,229,000 | $6,934,000 | $2,311,000 | Apr 22, 2010 |
| 118 | Remember Me (Summit) | $21,823,000 | $9,258,000 | $3,086,000 | Mar 12, 2010 |
| 119 | 127 Hours (Fox Searchlight) | $20,984,000 | $303,000 | $101,000 | Nov 05, 2010 |
| 120 | Going the Distance (2010) (Warner Bros. / New Line) | $20,377,000 | $7,880,000 | $2,627,000 | Sep 03, 2010 |
| 121 | Furry Vengeance (Summit) | $20,178,000 | $7,585,000 | $2,528,000 | Apr 30, 2010 |
| 122 | Splice (Warner Bros) | $19,468,000 | $8,452,000 | $2,817,000 | Jun 04, 2010 |
| 123 | The Ghost Writer (Summit) | $17,787,000 | $209,000 | $70,000 | Feb 19, 2010 |
| 124 | Youth in Revolt (The Weinstein Company) | $17,483,000 | $7,884,000 | $2,628,000 | Jan 08, 2010 |
| 125 | My Soul to Take (Universal / Rogue) | $16,875,000 | $7,831,000 | $2,610,000 | Oct 08, 2010 |
| 126 | Repo Men (Universal) | $15,787,000 | $7,011,000 | $2,337,000 | Mar 19, 2010 |
| 127 | Case 39 (Paramount Vantage) | $15,178,000 | $6,124,000 | $2,041,000 | Oct 01, 2010 |
| 128 | Extraordinary Measures (CBS Films) | $14,287,000 | $6,881,000 | $2,294,000 | Jan 22, 2010 |
| 129 | Let Me In (Relativity / Overture) | $13,888,000 | $5,891,000 | $1,964,000 | Oct 01, 2010 |
| 130 | Jonah Hex (Warner Bros.) | $12,071,000 | $6,156,000 | $2,052,000 | Jun 18, 2010 |
| 131 | The Girl with the Dragon Tattoo (2009) (Music Box) | $11,554,000 | $384,000 | $128,000 | Mar 19, 2010 |
| 132 | Blue Valentine (2010) (Weinstein Company) | $11,109,000 | $222,000 | $74,000 | Dec 29, 2010 |
| 133 | Fair Game (2010) (Summit) | $10,919,000 | $745,000 | $248,000 | Nov 05, 2010 |
| 134 | Get Low (Sony Pictures Classics) | $10,503,000 | $101,000 | $34,000 | Jul 30, 2010 |
| 135 | MacGruber (Universal / Rogue) | $9,757,000 | $4,627,000 | $1,542,000 | May 21, 2010 |
| 136 | The Girl Who Played With Fire (Music Box) | $8,742,000 | $1,036,000 | $345,000 | Jul 09, 2010 |
| 137 | Cyrus (Fox Searchlight) | $8,533,000 | $208,000 | $69,000 | Jun 18, 2010 |
| 138 | Babies (Focus) | $8,378,000 | $2,474,000 | $825,000 | May 07, 2010 |
| 139 | Conviction (Fox Searchlight) | $7,763,000 | $117,000 | $39,000 | Oct 15, 2010 |
| 140 | City Island (Anchor Bay) | $7,635,000 | $37,000 | $12,000 | Mar 19, 2010 |
| 141 | The Last Station (Sony Pictures Classics) | $7,574,000 | $84,000 | $28,000 | Jan 15, 2010 |
| 142 | Winter's Bone (Roadside Attractions) | $7,475,000 | $97,000 | $32,000 | Jun 11, 2010 |
| 143 | Waiting for 'Superman' (Paramount Vantage) | $7,344,000 | $159,000 | $53,000 | Sep 24, 2010 |
| 144 | The Secret in Their Eyes (2010) (Sony Pictures Classics) | $7,315,000 | $192,000 | $64,000 | Apr 16, 2010 |
| 145 | It's Kind of a Funny Story (Focus) | $7,283,000 | $2,304,000 | $768,000 | Oct 08, 2010 |
| 146 | The Warrior's Way (Relativity Media) | $6,475,000 | $3,489,000 | $1,163,000 | Dec 03, 2010 |
| 147 | The Girl Who Kicked the Hornet's Nest (Music Box) | $5,939,000 | $828,000 | $276,000 | Oct 29, 2010 |
| 148 | Biutiful (Roadside Attractions) | $5,838,000 | $52,000 | $17,000 | Dec 29, 2010 |
| 149 | I Am Love (Magnolia) | $5,729,000 | $139,000 | $46,000 | Jun 18, 2010 |
| 150 | Mao's Last Dancer (Samuel Goldwyn) | $5,514,000 | $229,000 | $76,000 | Aug 20, 2010 |
