| 1 | Toy Story 3 (Disney) | $481,805,000 | $128,063,000 | $42,688,000 | Jun 18, 2010 |
| 2 | Alice in Wonderland (2010) (Disney) | $387,984,000 | $134,789,000 | $44,930,000 | Mar 05, 2010 |
| 3 | Iron Man 2 (Paramount) | $362,370,000 | $148,745,000 | $49,582,000 | May 07, 2010 |
| 4 | The Twilight Saga: Eclipse (Summit) | $348,906,000 | $75,268,000 | $25,089,000 | Jun 30, 2010 |
| 5 | Harry Potter and the Deathly Hallows: Part 1 (Warner Bros.) | $343,626,000 | $145,141,000 | $48,380,000 | Nov 19, 2010 |
| 6 | Inception (Warner Bros.) | $339,670,000 | $72,891,000 | $24,297,000 | Jul 16, 2010 |
| 7 | Despicable Me (Universal) | $291,998,000 | $65,475,000 | $21,825,000 | Jul 09, 2010 |
| 8 | Shrek Forever After (Paramount / DreamWorks) | $276,769,000 | $82,241,000 | $27,414,000 | May 21, 2010 |
| 9 | How to Train Your Dragon (Paramount / DreamWorks) | $252,604,000 | $50,772,000 | $16,924,000 | Mar 26, 2010 |
| 10 | Tangled (Disney) | $233,147,000 | $56,617,000 | $18,872,000 | Nov 24, 2010 |
| 11 | The Karate Kid (2010) (Sony / Columbia) | $205,016,000 | $64,626,000 | $21,542,000 | Jun 11, 2010 |
| 12 | TRON: Legacy (Disney) | $199,759,000 | $51,113,000 | $17,038,000 | Dec 17, 2010 |
| 13 | True Grit (2010) (Paramount) | $198,583,000 | $28,827,000 | $9,609,000 | Dec 22, 2010 |
| 14 | Clash of the Titans (2010) (Warner Bros.) | $189,486,000 | $71,092,000 | $23,697,000 | Apr 02, 2010 |
| 15 | Grown Ups (Sony / Columbia) | $188,077,000 | $47,027,000 | $15,676,000 | Jun 25, 2010 |
| 16 | Little Fockers (Universal) | $172,332,000 | $35,797,000 | $11,932,000 | Dec 22, 2010 |
| 17 | Megamind (Paramount / DreamWorks) | $172,305,000 | $53,424,000 | $17,808,000 | Nov 05, 2010 |
| 18 | The King's Speech (Weinstein Company) | $161,139,000 | $413,000 | $138,000 | Nov 26, 2010 |
| 19 | The Last Airbender (Paramount) | $152,784,000 | $46,816,000 | $15,605,000 | Jul 01, 2010 |
| 20 | Shutter Island (Paramount) | $148,618,000 | $47,672,000 | $15,891,000 | Feb 19, 2010 |
| 21 | The Other Guys (Sony / Columbia) | $138,410,000 | $41,264,000 | $13,755,000 | Aug 06, 2010 |
| 22 | Salt (Sony / Columbia) | $137,355,000 | $41,808,000 | $13,936,000 | Jul 23, 2010 |
| 23 | Jackass 3D (Paramount) | $136,099,000 | $58,459,000 | $19,486,000 | Oct 15, 2010 |
| 24 | Valentine's Day (Warner Bros. / New Line) | $128,270,000 | $65,317,000 | $21,772,000 | Feb 12, 2010 |
| 25 | Black Swan (Fox Searchlight) | $124,170,000 | $1,676,000 | $559,000 | Dec 03, 2010 |
| 26 | Robin Hood (2010) (Universal) | $122,214,000 | $41,868,000 | $13,956,000 | May 14, 2010 |
| 27 | The Chronicles of Narnia: The Voyage of the Dawn Treader (Fox) | $121,189,000 | $27,869,000 | $9,290,000 | Dec 10, 2010 |
| 28 | The Expendables (Lionsgate) | $119,659,000 | $40,431,000 | $13,477,000 | Aug 13, 2010 |
| 29 | Due Date (Warner Bros.) | $116,722,000 | $37,951,000 | $12,650,000 | Nov 05, 2010 |
| 30 | Yogi Bear (Warner Bros.) | $116,382,000 | $19,053,000 | $6,351,000 | Dec 17, 2010 |
| 31 | Date Night (Fox) | $114,600,000 | $29,265,000 | $9,755,000 | Apr 09, 2010 |
| 32 | The Social Network (Sony / Columbia) | $112,570,000 | $26,059,000 | $8,686,000 | Oct 01, 2010 |
| 33 | Sex and the City 2 (Warner Bros. / New Line) | $110,695,000 | $35,992,000 | $11,997,000 | May 27, 2010 |
| 34 | The Book of Eli (Warner Bros.) | $110,100,000 | $38,067,000 | $12,689,000 | Jan 15, 2010 |
| 35 | The Fighter (Paramount) | $108,686,000 | $348,000 | $116,000 | Dec 10, 2010 |
| 36 | The Town (Warner Bros.) | $107,025,000 | $27,640,000 | $9,213,000 | Sep 17, 2010 |
| 37 | Prince of Persia: The Sands of Time (Disney) | $105,369,000 | $34,939,000 | $11,646,000 | May 28, 2010 |
| 38 | Red (2010) (Summit) | $104,928,000 | $25,264,000 | $8,421,000 | Oct 15, 2010 |
| 39 | Percy Jackson and the Olympians: The Lightning Thief (Fox) | $103,049,000 | $36,264,000 | $12,088,000 | Feb 12, 2010 |
| 40 | Paranormal Activity 2 (Paramount) | $98,395,000 | $47,226,000 | $15,742,000 | Oct 22, 2010 |
| 41 | Unstoppable (2010) (Fox) | $94,692,000 | $26,340,000 | $8,780,000 | Nov 12, 2010 |
| 42 | Eat Pray Love (Sony / Columbia) | $93,543,000 | $26,824,000 | $8,941,000 | Aug 13, 2010 |
| 43 | Dear John (Sony / Screen Gems) | $92,894,000 | $35,373,000 | $11,791,000 | Feb 05, 2010 |
| 44 | The A-Team (Fox) | $89,652,000 | $29,801,000 | $9,934,000 | Jun 11, 2010 |
| 45 | Knight and Day (Fox) | $88,724,000 | $23,382,000 | $7,794,000 | Jun 23, 2010 |
| 46 | Dinner for Schmucks (Paramount / DreamWorks) | $84,781,000 | $27,315,000 | $9,105,000 | Jul 30, 2010 |
| 47 | The Tourist (Sony / Columbia) | $78,517,000 | $19,124,000 | $6,375,000 | Dec 10, 2010 |
| 48 | The Bounty Hunter (Sony / Columbia) | $77,856,000 | $24,016,000 | $8,005,000 | Mar 19, 2010 |
| 49 | Diary of a Wimpy Kid (Fox) | $74,306,000 | $25,688,000 | $8,563,000 | Mar 19, 2010 |
| 50 | The Sorcerer's Apprentice (Disney) | $73,316,000 | $20,456,000 | $6,819,000 | Jul 14, 2010 |
| 51 | A Nightmare on Elm Street (2010) (Warner Bros. / New Line) | $73,228,000 | $38,198,000 | $12,733,000 | Apr 30, 2010 |
| 52 | The Last Song (Disney) | $73,083,000 | $18,584,000 | $6,195,000 | Mar 31, 2010 |
| 53 | The Wolfman (Universal) | $71,956,000 | $36,546,000 | $12,182,000 | Feb 12, 2010 |
| 54 | Get Him to the Greek (Universal) | $70,789,000 | $20,399,000 | $6,800,000 | Jun 04, 2010 |
| 55 | Resident Evil: Afterlife (Sony / Screen Gems) | $69,807,000 | $30,940,000 | $10,313,000 | Sep 10, 2010 |
| 56 | Tyler Perry's Why Did I Get Married Too? (Lionsgate) | $69,769,000 | $34,004,000 | $11,335,000 | Apr 02, 2010 |
| 57 | The Tooth Fairy (Fox) | $69,684,000 | $16,266,000 | $5,422,000 | Jan 22, 2010 |
| 58 | Secretariat (Disney) | $69,326,000 | $14,738,000 | $4,913,000 | Oct 08, 2010 |
| 59 | Easy A (Sony / Screen Gems) | $67,802,000 | $20,589,000 | $6,863,000 | Sep 17, 2010 |
| 60 | Takers (Sony / Screen Gems) | $67,039,000 | $23,814,000 | $7,938,000 | Aug 27, 2010 |
| 61 | Legend of the Guardians: The Owls of Ga'Hoole (Warner Bros.) | $64,637,000 | $18,706,000 | $6,235,000 | Sep 24, 2010 |
| 62 | Life As We Know It (Warner Bros.) | $61,966,000 | $16,841,000 | $5,614,000 | Oct 08, 2010 |
| 63 | Letters to Juliet (Summit) | $61,569,000 | $15,720,000 | $5,240,000 | May 14, 2010 |
| 64 | Hubble 3D (Warner Bros. / IMAX) | $60,977,000 | $477,000 | $159,000 | Mar 19, 2010 |
| 65 | Wall Street: Money Never Sleeps (Fox) | $60,921,000 | $22,071,000 | $7,357,000 | Sep 24, 2010 |
| 66 | Predators (Fox) | $60,371,000 | $28,746,000 | $9,582,000 | Jul 09, 2010 |
| 67 | Hot Tub Time Machine (MGM) | $58,383,000 | $16,277,000 | $5,426,000 | Mar 26, 2010 |
| 68 | Kick-Ass (Lionsgate) | $55,809,000 | $23,020,000 | $7,673,000 | Apr 16, 2010 |
| 69 | Killers (2010) (Lionsgate) | $54,635,000 | $18,386,000 | $6,129,000 | Jun 04, 2010 |
| 70 | Saw 3D (Lionsgate) | $53,068,000 | $28,130,000 | $9,377,000 | Oct 29, 2010 |
| 71 | Cop Out (Warner Bros.) | $52,098,000 | $21,142,000 | $7,047,000 | Feb 26, 2010 |
| 72 | Cats & Dogs: The Revenge of Kitty Galore (Warner Bros.) | $50,601,000 | $14,256,000 | $4,752,000 | Jul 30, 2010 |
| 73 | Edge of Darkness (Warner Bros.) | $50,285,000 | $19,985,000 | $6,662,000 | Jan 29, 2010 |
| 74 | Gulliver's Travels (2010) (Fox) | $49,665,000 | $7,323,000 | $2,441,000 | Dec 25, 2010 |
| 75 | Death at a Funeral (2010) (Sony / Screen Gems) | $49,619,000 | $18,828,000 | $6,276,000 | Apr 16, 2010 |
| 76 | Step Up 3D (Disney) | $49,225,000 | $18,358,000 | $6,119,000 | Aug 06, 2010 |
| 77 | The Last Exorcism (Lionsgate) | $47,639,000 | $23,645,000 | $7,882,000 | Aug 27, 2010 |
| 78 | Legion (Sony / Screen Gems) | $46,634,000 | $20,319,000 | $6,773,000 | Jan 22, 2010 |
| 79 | Burlesque (Sony / Screen Gems) | $45,789,000 | $13,871,000 | $4,624,000 | Nov 24, 2010 |
| 80 | The Crazies (Overture) | $45,421,000 | $18,654,000 | $6,218,000 | Feb 26, 2010 |
| 81 | For Colored Girls (Lionsgate) | $43,803,000 | $22,636,000 | $7,545,000 | Nov 05, 2010 |
| 82 | The Back-up Plan (CBS Films) | $43,525,000 | $14,166,000 | $4,722,000 | Apr 23, 2010 |
| 83 | Vampires Suck (Fox) | $42,563,000 | $14,167,000 | $4,722,000 | Aug 18, 2010 |
| 84 | The American (Focus) | $41,338,000 | $15,299,000 | $5,100,000 | Sep 01, 2010 |
| 85 | Green Zone (Universal) | $40,696,000 | $16,613,000 | $5,538,000 | Mar 12, 2010 |
| 86 | Marmaduke (Fox) | $39,060,000 | $13,467,000 | $4,489,000 | Jun 04, 2010 |
| 87 | Devil (Universal) | $39,010,000 | $14,268,000 | $4,756,000 | Sep 17, 2010 |
| 88 | Hereafter (Warner Bros.) | $38,018,000 | $256,000 | $85,000 | Oct 15, 2010 |
| 89 | When in Rome (Disney) | $37,928,000 | $14,338,000 | $4,779,000 | Jan 29, 2010 |
| 90 | Love and Other Drugs (Fox) | $37,577,000 | $11,307,000 | $3,769,000 | Nov 24, 2010 |
| 91 | She's Out of My League (Paramount) | $36,719,000 | $11,349,000 | $3,783,000 | Mar 12, 2010 |
| 92 | Scott Pilgrim vs. the World (Universal) | $36,599,000 | $12,318,000 | $4,106,000 | Aug 13, 2010 |
| 93 | Charlie St. Cloud (Universal) | $36,179,000 | $14,375,000 | $4,792,000 | Jul 30, 2010 |
| 94 | Morning Glory (2010) (Paramount) | $36,003,000 | $10,685,000 | $3,562,000 | Nov 10, 2010 |
| 95 | How Do You Know (Sony / Columbia) | $35,076,000 | $8,689,000 | $2,896,000 | Dec 17, 2010 |
| 96 | Daybreakers (Lionsgate) | $34,946,000 | $17,585,000 | $5,862,000 | Jan 08, 2010 |
| 97 | Nanny McPhee Returns (Universal) | $33,681,000 | $9,761,000 | $3,254,000 | Aug 20, 2010 |
| 98 | The Switch (2010) (Miramax) | $32,251,000 | $9,795,000 | $3,265,000 | Aug 20, 2010 |
| 99 | Brooklyn's Finest (Overture) | $31,536,000 | $15,499,000 | $5,166,000 | Mar 05, 2010 |
| 100 | Machete (Fox) | $30,874,000 | $13,254,000 | $4,418,000 | Sep 03, 2010 |
| 101 | Ramona and Beezus (Fox) | $30,379,000 | $9,068,000 | $3,023,000 | Jul 23, 2010 |
| 102 | Leap Year (2010) (Universal) | $30,091,000 | $10,684,000 | $3,561,000 | Jan 08, 2010 |
| 103 | You Again (Disney) | $29,839,000 | $9,761,000 | $3,254,000 | Sep 24, 2010 |
| 104 | Alpha and Omega (Lionsgate) | $29,149,000 | $10,573,000 | $3,524,000 | Sep 17, 2010 |
| 105 | Piranha 3D (Weinstein Company) | $29,028,000 | $11,734,000 | $3,911,000 | Aug 20, 2010 |
| 106 | Lottery Ticket (Warner Bros.) | $28,699,000 | $12,367,000 | $4,122,000 | Aug 20, 2010 |
| 107 | The Spy Next Door (Lionsgate) | $28,220,000 | $11,292,000 | $3,764,000 | Jan 15, 2010 |
| 108 | From Paris with Love (Lionsgate) | $27,953,000 | $9,472,000 | $3,157,000 | Feb 05, 2010 |
| 109 | The Losers (Warner Bros.) | $27,389,000 | $10,920,000 | $3,640,000 | Apr 23, 2010 |
| 110 | Faster (2010) (CBS Films) | $26,981,000 | $9,895,000 | $3,298,000 | Nov 24, 2010 |
| 111 | Just Wright (Fox Searchlight) | $24,989,000 | $9,619,000 | $3,206,000 | May 14, 2010 |
| 112 | Skyline (Universal / Rogue) | $24,837,000 | $13,574,000 | $4,525,000 | Nov 12, 2010 |
| 113 | The Next Three Days (Lionsgate) | $24,553,000 | $7,596,000 | $2,532,000 | Nov 19, 2010 |
| 114 | The Kids Are All Right (Focus) | $24,161,000 | $571,000 | $190,000 | Jul 09, 2010 |
| 115 | Our Family Wedding (Fox Searchlight) | $23,510,000 | $8,858,000 | $2,953,000 | Mar 12, 2010 |
| 116 | Country Strong (Sony / Screen Gems) | $23,473,000 | $35,000 | $12,000 | Dec 22, 2010 |
| 117 | Oceans (Disneynature) | $22,549,000 | $7,034,000 | $2,345,000 | Apr 22, 2010 |
| 118 | Remember Me (Summit) | $22,138,000 | $9,391,000 | $3,130,000 | Mar 12, 2010 |
| 119 | 127 Hours (Fox Searchlight) | $21,287,000 | $307,000 | $102,000 | Nov 05, 2010 |
| 120 | Going the Distance (2010) (Warner Bros. / New Line) | $20,670,000 | $7,993,000 | $2,664,000 | Sep 03, 2010 |
| 121 | Furry Vengeance (Summit) | $20,468,000 | $7,694,000 | $2,565,000 | Apr 30, 2010 |
| 122 | Splice (Warner Bros) | $19,748,000 | $8,574,000 | $2,858,000 | Jun 04, 2010 |
| 123 | The Ghost Writer (Summit) | $18,043,000 | $212,000 | $71,000 | Feb 19, 2010 |
| 124 | Youth in Revolt (The Weinstein Company) | $17,734,000 | $7,997,000 | $2,666,000 | Jan 08, 2010 |
| 125 | My Soul to Take (Universal / Rogue) | $17,118,000 | $7,944,000 | $2,648,000 | Oct 08, 2010 |
| 126 | Repo Men (Universal) | $16,015,000 | $7,112,000 | $2,371,000 | Mar 19, 2010 |
| 127 | Case 39 (Paramount Vantage) | $15,397,000 | $6,212,000 | $2,071,000 | Oct 01, 2010 |
| 128 | Extraordinary Measures (CBS Films) | $14,492,000 | $6,980,000 | $2,327,000 | Jan 22, 2010 |
| 129 | Let Me In (Relativity / Overture) | $14,088,000 | $5,976,000 | $1,992,000 | Oct 01, 2010 |
| 130 | Jonah Hex (Warner Bros.) | $12,245,000 | $6,245,000 | $2,082,000 | Jun 18, 2010 |
| 131 | The Girl with the Dragon Tattoo (2009) (Music Box) | $11,720,000 | $390,000 | $130,000 | Mar 19, 2010 |
| 132 | Blue Valentine (2010) (Weinstein Company) | $11,269,000 | $225,000 | $75,000 | Dec 29, 2010 |
| 133 | Fair Game (2010) (Summit) | $11,076,000 | $756,000 | $252,000 | Nov 05, 2010 |
| 134 | Get Low (Sony Pictures Classics) | $10,654,000 | $102,000 | $34,000 | Jul 30, 2010 |
| 135 | MacGruber (Universal / Rogue) | $9,898,000 | $4,694,000 | $1,565,000 | May 21, 2010 |
| 136 | The Girl Who Played With Fire (Music Box) | $8,868,000 | $1,051,000 | $350,000 | Jul 09, 2010 |
| 137 | Cyrus (Fox Searchlight) | $8,655,000 | $211,000 | $70,000 | Jun 18, 2010 |
| 138 | Babies (Focus) | $8,499,000 | $2,509,000 | $836,000 | May 07, 2010 |
| 139 | Conviction (Fox Searchlight) | $7,875,000 | $119,000 | $40,000 | Oct 15, 2010 |
| 140 | City Island (Anchor Bay) | $7,745,000 | $37,000 | $12,000 | Mar 19, 2010 |
| 141 | The Last Station (Sony Pictures Classics) | $7,683,000 | $86,000 | $29,000 | Jan 15, 2010 |
| 142 | Winter's Bone (Roadside Attractions) | $7,583,000 | $99,000 | $33,000 | Jun 11, 2010 |
| 143 | Waiting for 'Superman' (Paramount Vantage) | $7,450,000 | $161,000 | $54,000 | Sep 24, 2010 |
| 144 | The Secret in Their Eyes (2010) (Sony Pictures Classics) | $7,420,000 | $195,000 | $65,000 | Apr 16, 2010 |
| 145 | It's Kind of a Funny Story (Focus) | $7,388,000 | $2,337,000 | $779,000 | Oct 08, 2010 |
| 146 | The Warrior's Way (Relativity Media) | $6,568,000 | $3,539,000 | $1,180,000 | Dec 03, 2010 |
| 147 | The Girl Who Kicked the Hornet's Nest (Music Box) | $6,025,000 | $840,000 | $280,000 | Oct 29, 2010 |
| 148 | Biutiful (Roadside Attractions) | $5,922,000 | $53,000 | $18,000 | Dec 29, 2010 |
| 149 | I Am Love (Magnolia) | $5,811,000 | $141,000 | $47,000 | Jun 18, 2010 |
| 150 | Mao's Last Dancer (Samuel Goldwyn) | $5,593,000 | $232,000 | $77,000 | Aug 20, 2010 |
| 151 | Solitary Man (Anchor Bay) | $5,062,000 | $110,000 | $37,000 | May 21, 2010 |
| 152 | Inside Job (Sony Pictures Classics) | $5,007,000 | $46,000 | $15,000 | Oct 08, 2010 |
