| 1 | Toy Story 3 (Disney) | $480,753,000 | $127,783,000 | $42,594,000 | Jun 18, 2010 |
| 2 | Alice in Wonderland (2010) (Disney) | $387,136,000 | $134,495,000 | $44,832,000 | Mar 05, 2010 |
| 3 | Iron Man 2 (Paramount) | $361,578,000 | $148,421,000 | $49,474,000 | May 07, 2010 |
| 4 | The Twilight Saga: Eclipse (Summit) | $348,145,000 | $75,103,000 | $25,034,000 | Jun 30, 2010 |
| 5 | Harry Potter and the Deathly Hallows: Part 1 (Warner Bros.) | $342,875,000 | $144,824,000 | $48,275,000 | Nov 19, 2010 |
| 6 | Inception (Warner Bros.) | $338,929,000 | $72,732,000 | $24,244,000 | Jul 16, 2010 |
| 7 | Despicable Me (Universal) | $291,361,000 | $65,332,000 | $21,777,000 | Jul 09, 2010 |
| 8 | Shrek Forever After (Paramount / DreamWorks) | $276,165,000 | $82,061,000 | $27,354,000 | May 21, 2010 |
| 9 | How to Train Your Dragon (Paramount / DreamWorks) | $252,052,000 | $50,661,000 | $16,887,000 | Mar 26, 2010 |
| 10 | Tangled (Disney) | $232,638,000 | $56,493,000 | $18,831,000 | Nov 24, 2010 |
| 11 | The Karate Kid (2010) (Sony / Columbia) | $204,569,000 | $64,485,000 | $21,495,000 | Jun 11, 2010 |
| 12 | TRON: Legacy (Disney) | $199,322,000 | $51,001,000 | $17,000,000 | Dec 17, 2010 |
| 13 | True Grit (2010) (Paramount) | $198,150,000 | $28,764,000 | $9,588,000 | Dec 22, 2010 |
| 14 | Clash of the Titans (2010) (Warner Bros.) | $189,073,000 | $70,936,000 | $23,645,000 | Apr 02, 2010 |
| 15 | Grown Ups (Sony / Columbia) | $187,667,000 | $46,924,000 | $15,641,000 | Jun 25, 2010 |
| 16 | Little Fockers (Universal) | $171,955,000 | $35,719,000 | $11,906,000 | Dec 22, 2010 |
| 17 | Megamind (Paramount / DreamWorks) | $171,929,000 | $53,307,000 | $17,769,000 | Nov 05, 2010 |
| 18 | The King's Speech (Weinstein Company) | $160,787,000 | $412,000 | $137,000 | Nov 26, 2010 |
| 19 | The Last Airbender (Paramount) | $152,450,000 | $46,714,000 | $15,571,000 | Jul 01, 2010 |
| 20 | Shutter Island (Paramount) | $148,294,000 | $47,568,000 | $15,856,000 | Feb 19, 2010 |
| 21 | The Other Guys (Sony / Columbia) | $138,108,000 | $41,174,000 | $13,725,000 | Aug 06, 2010 |
| 22 | Salt (Sony / Columbia) | $137,055,000 | $41,716,000 | $13,905,000 | Jul 23, 2010 |
| 23 | Jackass 3D (Paramount) | $135,802,000 | $58,331,000 | $19,444,000 | Oct 15, 2010 |
| 24 | Valentine's Day (Warner Bros. / New Line) | $127,990,000 | $65,174,000 | $21,725,000 | Feb 12, 2010 |
| 25 | Black Swan (Fox Searchlight) | $123,899,000 | $1,673,000 | $558,000 | Dec 03, 2010 |
| 26 | Robin Hood (2010) (Universal) | $121,947,000 | $41,776,000 | $13,925,000 | May 14, 2010 |
| 27 | The Chronicles of Narnia: The Voyage of the Dawn Treader (Fox) | $120,925,000 | $27,808,000 | $9,269,000 | Dec 10, 2010 |
| 28 | The Expendables (Lionsgate) | $119,398,000 | $40,342,000 | $13,447,000 | Aug 13, 2010 |
| 29 | Due Date (Warner Bros.) | $116,467,000 | $37,868,000 | $12,623,000 | Nov 05, 2010 |
| 30 | Yogi Bear (Warner Bros.) | $116,128,000 | $19,011,000 | $6,337,000 | Dec 17, 2010 |
| 31 | Date Night (Fox) | $114,350,000 | $29,201,000 | $9,734,000 | Apr 09, 2010 |
| 32 | The Social Network (Sony / Columbia) | $112,324,000 | $26,002,000 | $8,667,000 | Oct 01, 2010 |
| 33 | Sex and the City 2 (Warner Bros. / New Line) | $110,453,000 | $35,914,000 | $11,971,000 | May 27, 2010 |
| 34 | The Book of Eli (Warner Bros.) | $109,860,000 | $37,984,000 | $12,661,000 | Jan 15, 2010 |
| 35 | The Fighter (Paramount) | $108,449,000 | $348,000 | $116,000 | Dec 10, 2010 |
| 36 | The Town (Warner Bros.) | $106,791,000 | $27,580,000 | $9,193,000 | Sep 17, 2010 |
| 37 | Prince of Persia: The Sands of Time (Disney) | $105,139,000 | $34,863,000 | $11,621,000 | May 28, 2010 |
| 38 | Red (2010) (Summit) | $104,699,000 | $25,209,000 | $8,403,000 | Oct 15, 2010 |
| 39 | Percy Jackson and the Olympians: The Lightning Thief (Fox) | $102,824,000 | $36,185,000 | $12,062,000 | Feb 12, 2010 |
| 40 | Paranormal Activity 2 (Paramount) | $98,180,000 | $47,123,000 | $15,708,000 | Oct 22, 2010 |
| 41 | Unstoppable (2010) (Fox) | $94,485,000 | $26,283,000 | $8,761,000 | Nov 12, 2010 |
| 42 | Eat Pray Love (Sony / Columbia) | $93,339,000 | $26,765,000 | $8,922,000 | Aug 13, 2010 |
| 43 | Dear John (Sony / Screen Gems) | $92,691,000 | $35,296,000 | $11,765,000 | Feb 05, 2010 |
| 44 | The A-Team (Fox) | $89,456,000 | $29,736,000 | $9,912,000 | Jun 11, 2010 |
| 45 | Knight and Day (Fox) | $88,531,000 | $23,331,000 | $7,777,000 | Jun 23, 2010 |
| 46 | Dinner for Schmucks (Paramount / DreamWorks) | $84,596,000 | $27,255,000 | $9,085,000 | Jul 30, 2010 |
| 47 | The Tourist (Sony / Columbia) | $78,346,000 | $19,082,000 | $6,361,000 | Dec 10, 2010 |
| 48 | The Bounty Hunter (Sony / Columbia) | $77,686,000 | $23,964,000 | $7,988,000 | Mar 19, 2010 |
| 49 | Diary of a Wimpy Kid (Fox) | $74,144,000 | $25,632,000 | $8,544,000 | Mar 19, 2010 |
| 50 | The Sorcerer's Apprentice (Disney) | $73,156,000 | $20,411,000 | $6,804,000 | Jul 14, 2010 |
| 51 | A Nightmare on Elm Street (2010) (Warner Bros. / New Line) | $73,068,000 | $38,115,000 | $12,705,000 | Apr 30, 2010 |
| 52 | The Last Song (Disney) | $72,924,000 | $18,543,000 | $6,181,000 | Mar 31, 2010 |
| 53 | The Wolfman (Universal) | $71,799,000 | $36,466,000 | $12,155,000 | Feb 12, 2010 |
| 54 | Get Him to the Greek (Universal) | $70,635,000 | $20,355,000 | $6,785,000 | Jun 04, 2010 |
| 55 | Resident Evil: Afterlife (Sony / Screen Gems) | $69,655,000 | $30,872,000 | $10,291,000 | Sep 10, 2010 |
| 56 | Tyler Perry's Why Did I Get Married Too? (Lionsgate) | $69,617,000 | $33,930,000 | $11,310,000 | Apr 02, 2010 |
| 57 | The Tooth Fairy (Fox) | $69,531,000 | $16,230,000 | $5,410,000 | Jan 22, 2010 |
| 58 | Secretariat (Disney) | $69,174,000 | $14,706,000 | $4,902,000 | Oct 08, 2010 |
| 59 | Easy A (Sony / Screen Gems) | $67,654,000 | $20,544,000 | $6,848,000 | Sep 17, 2010 |
| 60 | Takers (Sony / Screen Gems) | $66,893,000 | $23,762,000 | $7,921,000 | Aug 27, 2010 |
| 61 | Legend of the Guardians: The Owls of Ga'Hoole (Warner Bros.) | $64,496,000 | $18,665,000 | $6,222,000 | Sep 24, 2010 |
| 62 | Life As We Know It (Warner Bros.) | $61,831,000 | $16,805,000 | $5,602,000 | Oct 08, 2010 |
| 63 | Letters to Juliet (Summit) | $61,434,000 | $15,686,000 | $5,229,000 | May 14, 2010 |
| 64 | Wall Street: Money Never Sleeps (Fox) | $60,788,000 | $22,023,000 | $7,341,000 | Sep 24, 2010 |
| 65 | Predators (Fox) | $60,239,000 | $28,684,000 | $9,561,000 | Jul 09, 2010 |
| 66 | Hubble 3D (Warner Bros. / IMAX) | $60,096,000 | $476,000 | $159,000 | Mar 19, 2010 |
| 67 | Hot Tub Time Machine (MGM) | $58,255,000 | $16,242,000 | $5,414,000 | Mar 26, 2010 |
| 68 | Kick-Ass (Lionsgate) | $55,687,000 | $22,970,000 | $7,657,000 | Apr 16, 2010 |
| 69 | Killers (2010) (Lionsgate) | $54,516,000 | $18,346,000 | $6,115,000 | Jun 04, 2010 |
| 70 | Saw 3D (Lionsgate) | $52,952,000 | $28,069,000 | $9,356,000 | Oct 29, 2010 |
| 71 | Cop Out (Warner Bros.) | $51,984,000 | $21,096,000 | $7,032,000 | Feb 26, 2010 |
| 72 | Cats & Dogs: The Revenge of Kitty Galore (Warner Bros.) | $50,491,000 | $14,225,000 | $4,742,000 | Jul 30, 2010 |
| 73 | Edge of Darkness (Warner Bros.) | $50,175,000 | $19,942,000 | $6,647,000 | Jan 29, 2010 |
| 74 | Gulliver's Travels (2010) (Fox) | $49,557,000 | $7,307,000 | $2,436,000 | Dec 25, 2010 |
| 75 | Death at a Funeral (2010) (Sony / Screen Gems) | $49,510,000 | $18,787,000 | $6,262,000 | Apr 16, 2010 |
| 76 | Step Up 3D (Disney) | $49,118,000 | $18,317,000 | $6,106,000 | Aug 06, 2010 |
| 77 | The Last Exorcism (Lionsgate) | $47,535,000 | $23,593,000 | $7,864,000 | Aug 27, 2010 |
| 78 | Legion (Sony / Screen Gems) | $46,532,000 | $20,274,000 | $6,758,000 | Jan 22, 2010 |
| 79 | Burlesque (Sony / Screen Gems) | $45,689,000 | $13,841,000 | $4,614,000 | Nov 24, 2010 |
| 80 | The Crazies (Overture) | $45,322,000 | $18,613,000 | $6,204,000 | Feb 26, 2010 |
| 81 | For Colored Girls (Lionsgate) | $43,707,000 | $22,586,000 | $7,529,000 | Nov 05, 2010 |
| 82 | The Back-up Plan (CBS Films) | $43,429,000 | $14,135,000 | $4,712,000 | Apr 23, 2010 |
| 83 | Vampires Suck (Fox) | $42,470,000 | $14,136,000 | $4,712,000 | Aug 18, 2010 |
| 84 | The American (Focus) | $41,247,000 | $15,266,000 | $5,089,000 | Sep 01, 2010 |
| 85 | Green Zone (Universal) | $40,607,000 | $16,576,000 | $5,525,000 | Mar 12, 2010 |
| 86 | Marmaduke (Fox) | $38,975,000 | $13,437,000 | $4,479,000 | Jun 04, 2010 |
| 87 | Devil (Universal) | $38,925,000 | $14,236,000 | $4,745,000 | Sep 17, 2010 |
| 88 | Hereafter (Warner Bros.) | $37,935,000 | $255,000 | $85,000 | Oct 15, 2010 |
| 89 | When in Rome (Disney) | $37,845,000 | $14,307,000 | $4,769,000 | Jan 29, 2010 |
| 90 | Love and Other Drugs (Fox) | $37,495,000 | $11,282,000 | $3,761,000 | Nov 24, 2010 |
| 91 | She's Out of My League (Paramount) | $36,639,000 | $11,324,000 | $3,775,000 | Mar 12, 2010 |
| 92 | Scott Pilgrim vs. the World (Universal) | $36,519,000 | $12,291,000 | $4,097,000 | Aug 13, 2010 |
| 93 | Charlie St. Cloud (Universal) | $36,100,000 | $14,343,000 | $4,781,000 | Jul 30, 2010 |
| 94 | Morning Glory (2010) (Paramount) | $35,925,000 | $10,661,000 | $3,554,000 | Nov 10, 2010 |
| 95 | How Do You Know (Sony / Columbia) | $34,999,000 | $8,670,000 | $2,890,000 | Dec 17, 2010 |
| 96 | Daybreakers (Lionsgate) | $34,870,000 | $17,546,000 | $5,849,000 | Jan 08, 2010 |
| 97 | Nanny McPhee Returns (Universal) | $33,607,000 | $9,740,000 | $3,247,000 | Aug 20, 2010 |
| 98 | The Switch (2010) (Miramax) | $32,180,000 | $9,773,000 | $3,258,000 | Aug 20, 2010 |
| 99 | Brooklyn's Finest (Overture) | $31,467,000 | $15,465,000 | $5,155,000 | Mar 05, 2010 |
| 100 | Machete (Fox) | $30,807,000 | $13,225,000 | $4,408,000 | Sep 03, 2010 |
| 101 | Ramona and Beezus (Fox) | $30,313,000 | $9,048,000 | $3,016,000 | Jul 23, 2010 |
| 102 | Leap Year (2010) (Universal) | $30,025,000 | $10,661,000 | $3,554,000 | Jan 08, 2010 |
| 103 | You Again (Disney) | $29,774,000 | $9,740,000 | $3,247,000 | Sep 24, 2010 |
| 104 | Alpha and Omega (Lionsgate) | $29,085,000 | $10,550,000 | $3,517,000 | Sep 17, 2010 |
| 105 | Piranha 3D (Weinstein Company) | $28,964,000 | $11,708,000 | $3,903,000 | Aug 20, 2010 |
| 106 | Lottery Ticket (Warner Bros.) | $28,636,000 | $12,340,000 | $4,113,000 | Aug 20, 2010 |
| 107 | The Spy Next Door (Lionsgate) | $28,159,000 | $11,267,000 | $3,756,000 | Jan 15, 2010 |
| 108 | From Paris with Love (Lionsgate) | $27,892,000 | $9,451,000 | $3,150,000 | Feb 05, 2010 |
| 109 | The Losers (Warner Bros.) | $27,329,000 | $10,897,000 | $3,632,000 | Apr 23, 2010 |
| 110 | Faster (2010) (CBS Films) | $26,922,000 | $9,873,000 | $3,291,000 | Nov 24, 2010 |
| 111 | Just Wright (Fox Searchlight) | $24,934,000 | $9,598,000 | $3,199,000 | May 14, 2010 |
| 112 | Skyline (Universal / Rogue) | $24,783,000 | $13,545,000 | $4,515,000 | Nov 12, 2010 |
| 113 | The Next Three Days (Lionsgate) | $24,499,000 | $7,579,000 | $2,526,000 | Nov 19, 2010 |
| 114 | The Kids Are All Right (Focus) | $24,108,000 | $570,000 | $190,000 | Jul 09, 2010 |
| 115 | Our Family Wedding (Fox Searchlight) | $23,458,000 | $8,839,000 | $2,946,000 | Mar 12, 2010 |
| 116 | Country Strong (Sony / Screen Gems) | $23,422,000 | $35,000 | $12,000 | Dec 22, 2010 |
| 117 | Oceans (Disneynature) | $22,499,000 | $7,019,000 | $2,340,000 | Apr 22, 2010 |
| 118 | Remember Me (Summit) | $22,089,000 | $9,371,000 | $3,124,000 | Mar 12, 2010 |
| 119 | 127 Hours (Fox Searchlight) | $21,240,000 | $307,000 | $102,000 | Nov 05, 2010 |
| 120 | Going the Distance (2010) (Warner Bros. / New Line) | $20,625,000 | $7,976,000 | $2,659,000 | Sep 03, 2010 |
| 121 | Furry Vengeance (Summit) | $20,424,000 | $7,678,000 | $2,559,000 | Apr 30, 2010 |
| 122 | Splice (Warner Bros) | $19,705,000 | $8,555,000 | $2,852,000 | Jun 04, 2010 |
| 123 | The Ghost Writer (Summit) | $18,004,000 | $212,000 | $71,000 | Feb 19, 2010 |
| 124 | Youth in Revolt (The Weinstein Company) | $17,696,000 | $7,980,000 | $2,660,000 | Jan 08, 2010 |
| 125 | My Soul to Take (Universal / Rogue) | $17,080,000 | $7,926,000 | $2,642,000 | Oct 08, 2010 |
| 126 | Repo Men (Universal) | $15,980,000 | $7,097,000 | $2,366,000 | Mar 19, 2010 |
| 127 | Case 39 (Paramount Vantage) | $15,363,000 | $6,198,000 | $2,066,000 | Oct 01, 2010 |
| 128 | Extraordinary Measures (CBS Films) | $14,461,000 | $6,965,000 | $2,322,000 | Jan 22, 2010 |
| 129 | Let Me In (Relativity / Overture) | $14,057,000 | $5,963,000 | $1,988,000 | Oct 01, 2010 |
| 130 | Jonah Hex (Warner Bros.) | $12,218,000 | $6,231,000 | $2,077,000 | Jun 18, 2010 |
| 131 | The Girl with the Dragon Tattoo (2009) (Music Box) | $11,695,000 | $389,000 | $130,000 | Mar 19, 2010 |
| 132 | Blue Valentine (2010) (Weinstein Company) | $11,244,000 | $224,000 | $75,000 | Dec 29, 2010 |
| 133 | Fair Game (2010) (Summit) | $11,052,000 | $754,000 | $251,000 | Nov 05, 2010 |
| 134 | Get Low (Sony Pictures Classics) | $10,631,000 | $102,000 | $34,000 | Jul 30, 2010 |
| 135 | MacGruber (Universal / Rogue) | $9,876,000 | $4,684,000 | $1,561,000 | May 21, 2010 |
| 136 | The Girl Who Played With Fire (Music Box) | $8,848,000 | $1,048,000 | $349,000 | Jul 09, 2010 |
| 137 | Cyrus (Fox Searchlight) | $8,637,000 | $211,000 | $70,000 | Jun 18, 2010 |
| 138 | Babies (Focus) | $8,480,000 | $2,504,000 | $835,000 | May 07, 2010 |
| 139 | Conviction (Fox Searchlight) | $7,858,000 | $119,000 | $40,000 | Oct 15, 2010 |
| 140 | City Island (Anchor Bay) | $7,728,000 | $37,000 | $12,000 | Mar 19, 2010 |
| 141 | The Last Station (Sony Pictures Classics) | $7,666,000 | $85,000 | $28,000 | Jan 15, 2010 |
| 142 | Winter's Bone (Roadside Attractions) | $7,566,000 | $98,000 | $33,000 | Jun 11, 2010 |
| 143 | Waiting for 'Superman' (Paramount Vantage) | $7,434,000 | $161,000 | $54,000 | Sep 24, 2010 |
| 144 | The Secret in Their Eyes (2010) (Sony Pictures Classics) | $7,404,000 | $194,000 | $65,000 | Apr 16, 2010 |
| 145 | It's Kind of a Funny Story (Focus) | $7,372,000 | $2,332,000 | $777,000 | Oct 08, 2010 |
| 146 | The Warrior's Way (Relativity Media) | $6,554,000 | $3,532,000 | $1,177,000 | Dec 03, 2010 |
| 147 | The Girl Who Kicked the Hornet's Nest (Music Box) | $6,012,000 | $838,000 | $279,000 | Oct 29, 2010 |
| 148 | Biutiful (Roadside Attractions) | $5,909,000 | $52,000 | $17,000 | Dec 29, 2010 |
| 149 | I Am Love (Magnolia) | $5,798,000 | $141,000 | $47,000 | Jun 18, 2010 |
| 150 | Mao's Last Dancer (Samuel Goldwyn) | $5,581,000 | $231,000 | $77,000 | Aug 20, 2010 |
| 151 | Solitary Man (Anchor Bay) | $5,051,000 | $110,000 | $37,000 | May 21, 2010 |
