| 1 | Toy Story 3 (Disney) | $467,604,000 | $124,288,000 | $41,429,000 | Jun 18, 2010 |
| 2 | Alice in Wonderland (2010) (Disney) | $376,547,000 | $130,816,000 | $43,605,000 | Mar 05, 2010 |
| 3 | Iron Man 2 (Paramount) | $351,688,000 | $144,361,000 | $48,120,000 | May 07, 2010 |
| 4 | The Twilight Saga: Eclipse (Summit) | $338,622,000 | $73,049,000 | $24,350,000 | Jun 30, 2010 |
| 5 | Harry Potter and the Deathly Hallows: Part 1 (Warner Bros.) | $333,497,000 | $140,862,000 | $46,954,000 | Nov 19, 2010 |
| 6 | Inception (Warner Bros.) | $329,658,000 | $70,743,000 | $23,581,000 | Jul 16, 2010 |
| 7 | Despicable Me (Universal) | $283,392,000 | $63,545,000 | $21,182,000 | Jul 09, 2010 |
| 8 | Shrek Forever After (Paramount / DreamWorks) | $268,611,000 | $79,816,000 | $26,605,000 | May 21, 2010 |
| 9 | How to Train Your Dragon (Paramount / DreamWorks) | $245,158,000 | $49,275,000 | $16,425,000 | Mar 26, 2010 |
| 10 | Tangled (Disney) | $226,275,000 | $54,948,000 | $18,316,000 | Nov 24, 2010 |
| 11 | The Karate Kid (2010) (Sony / Columbia) | $198,973,000 | $62,721,000 | $20,907,000 | Jun 11, 2010 |
| 12 | TRON: Legacy (Disney) | $193,870,000 | $49,606,000 | $16,535,000 | Dec 17, 2010 |
| 13 | True Grit (2010) (Paramount) | $192,730,000 | $27,978,000 | $9,326,000 | Dec 22, 2010 |
| 14 | Clash of the Titans (2010) (Warner Bros.) | $183,901,000 | $68,996,000 | $22,999,000 | Apr 02, 2010 |
| 15 | Grown Ups (Sony / Columbia) | $182,534,000 | $45,640,000 | $15,213,000 | Jun 25, 2010 |
| 16 | Little Fockers (Universal) | $167,252,000 | $34,742,000 | $11,581,000 | Dec 22, 2010 |
| 17 | Megamind (Paramount / DreamWorks) | $167,226,000 | $51,849,000 | $17,283,000 | Nov 05, 2010 |
| 18 | The King's Speech (Weinstein Company) | $156,389,000 | $401,000 | $134,000 | Nov 26, 2010 |
| 19 | The Last Airbender (Paramount) | $148,281,000 | $45,436,000 | $15,145,000 | Jul 01, 2010 |
| 20 | Shutter Island (Paramount) | $144,238,000 | $46,267,000 | $15,422,000 | Feb 19, 2010 |
| 21 | The Other Guys (Sony / Columbia) | $134,330,000 | $40,048,000 | $13,349,000 | Aug 06, 2010 |
| 22 | Salt (Sony / Columbia) | $133,306,000 | $40,575,000 | $13,525,000 | Jul 23, 2010 |
| 23 | Jackass 3D (Paramount) | $132,088,000 | $56,736,000 | $18,912,000 | Oct 15, 2010 |
| 24 | Valentine's Day (Warner Bros. / New Line) | $124,489,000 | $63,391,000 | $21,130,000 | Feb 12, 2010 |
| 25 | Black Swan (Fox Searchlight) | $120,510,000 | $1,627,000 | $542,000 | Dec 03, 2010 |
| 26 | Robin Hood (2010) (Universal) | $118,612,000 | $40,634,000 | $13,545,000 | May 14, 2010 |
| 27 | The Chronicles of Narnia: The Voyage of the Dawn Treader (Fox) | $117,617,000 | $27,048,000 | $9,016,000 | Dec 10, 2010 |
| 28 | The Expendables (Lionsgate) | $116,132,000 | $39,239,000 | $13,080,000 | Aug 13, 2010 |
| 29 | Due Date (Warner Bros.) | $113,282,000 | $36,833,000 | $12,278,000 | Nov 05, 2010 |
| 30 | Yogi Bear (Warner Bros.) | $112,951,000 | $18,491,000 | $6,164,000 | Dec 17, 2010 |
| 31 | Date Night (Fox) | $111,222,000 | $28,402,000 | $9,467,000 | Apr 09, 2010 |
| 32 | The Social Network (Sony / Columbia) | $109,252,000 | $25,290,000 | $8,430,000 | Oct 01, 2010 |
| 33 | Sex and the City 2 (Warner Bros. / New Line) | $107,432,000 | $34,931,000 | $11,644,000 | May 27, 2010 |
| 34 | The Book of Eli (Warner Bros.) | $106,855,000 | $36,945,000 | $12,315,000 | Jan 15, 2010 |
| 35 | The Fighter (Paramount) | $105,482,000 | $338,000 | $113,000 | Dec 10, 2010 |
| 36 | The Town (Warner Bros.) | $103,870,000 | $26,826,000 | $8,942,000 | Sep 17, 2010 |
| 37 | Prince of Persia: The Sands of Time (Disney) | $102,263,000 | $33,910,000 | $11,303,000 | May 28, 2010 |
| 38 | Red (2010) (Summit) | $101,835,000 | $24,520,000 | $8,173,000 | Oct 15, 2010 |
| 39 | Percy Jackson and the Olympians: The Lightning Thief (Fox) | $100,012,000 | $35,195,000 | $11,732,000 | Feb 12, 2010 |
| 40 | Paranormal Activity 2 (Paramount) | $95,495,000 | $45,834,000 | $15,278,000 | Oct 22, 2010 |
| 41 | Unstoppable (2010) (Fox) | $91,900,000 | $25,564,000 | $8,521,000 | Nov 12, 2010 |
| 42 | Eat Pray Love (Sony / Columbia) | $90,786,000 | $26,033,000 | $8,678,000 | Aug 13, 2010 |
| 43 | Dear John (Sony / Screen Gems) | $90,156,000 | $34,330,000 | $11,443,000 | Feb 05, 2010 |
| 44 | The A-Team (Fox) | $87,009,000 | $28,923,000 | $9,641,000 | Jun 11, 2010 |
| 45 | Knight and Day (Fox) | $86,109,000 | $22,693,000 | $7,564,000 | Jun 23, 2010 |
| 46 | Dinner for Schmucks (Paramount / DreamWorks) | $82,282,000 | $26,510,000 | $8,837,000 | Jul 30, 2010 |
| 47 | The Tourist (Sony / Columbia) | $76,203,000 | $18,560,000 | $6,187,000 | Dec 10, 2010 |
| 48 | The Bounty Hunter (Sony / Columbia) | $75,561,000 | $23,308,000 | $7,769,000 | Mar 19, 2010 |
| 49 | Diary of a Wimpy Kid (Fox) | $72,116,000 | $24,930,000 | $8,310,000 | Mar 19, 2010 |
| 50 | The Sorcerer's Apprentice (Disney) | $71,155,000 | $19,853,000 | $6,618,000 | Jul 14, 2010 |
| 51 | A Nightmare on Elm Street (2010) (Warner Bros. / New Line) | $71,069,000 | $37,072,000 | $12,357,000 | Apr 30, 2010 |
| 52 | The Last Song (Disney) | $70,929,000 | $18,036,000 | $6,012,000 | Mar 31, 2010 |
| 53 | The Wolfman (Universal) | $69,835,000 | $35,469,000 | $11,823,000 | Feb 12, 2010 |
| 54 | Get Him to the Greek (Universal) | $68,703,000 | $19,798,000 | $6,599,000 | Jun 04, 2010 |
| 55 | Resident Evil: Afterlife (Sony / Screen Gems) | $67,749,000 | $30,028,000 | $10,009,000 | Sep 10, 2010 |
| 56 | Tyler Perry's Why Did I Get Married Too? (Lionsgate) | $67,713,000 | $33,002,000 | $11,001,000 | Apr 02, 2010 |
| 57 | The Tooth Fairy (Fox) | $67,630,000 | $15,786,000 | $5,262,000 | Jan 22, 2010 |
| 58 | Secretariat (Disney) | $67,282,000 | $14,304,000 | $4,768,000 | Oct 08, 2010 |
| 59 | Easy A (Sony / Screen Gems) | $65,803,000 | $19,982,000 | $6,661,000 | Sep 17, 2010 |
| 60 | Takers (Sony / Screen Gems) | $65,063,000 | $23,112,000 | $7,704,000 | Aug 27, 2010 |
| 61 | Legend of the Guardians: The Owls of Ga'Hoole (Warner Bros.) | $62,732,000 | $18,154,000 | $6,051,000 | Sep 24, 2010 |
| 62 | Life As We Know It (Warner Bros.) | $60,140,000 | $16,345,000 | $5,448,000 | Oct 08, 2010 |
| 63 | Letters to Juliet (Summit) | $59,754,000 | $15,257,000 | $5,086,000 | May 14, 2010 |
| 64 | Wall Street: Money Never Sleeps (Fox) | $59,125,000 | $21,421,000 | $7,140,000 | Sep 24, 2010 |
| 65 | Predators (Fox) | $58,591,000 | $27,899,000 | $9,300,000 | Jul 09, 2010 |
| 66 | Hubble 3D (Warner Bros. / IMAX) | $58,264,000 | $463,000 | $154,000 | Mar 19, 2010 |
| 67 | Hot Tub Time Machine (MGM) | $56,662,000 | $15,797,000 | $5,266,000 | Mar 26, 2010 |
| 68 | Kick-Ass (Lionsgate) | $54,164,000 | $22,342,000 | $7,447,000 | Apr 16, 2010 |
| 69 | Killers (2010) (Lionsgate) | $53,024,000 | $17,845,000 | $5,948,000 | Jun 04, 2010 |
| 70 | Saw 3D (Lionsgate) | $51,504,000 | $27,301,000 | $9,100,000 | Oct 29, 2010 |
| 71 | Cop Out (Warner Bros.) | $50,563,000 | $20,519,000 | $6,840,000 | Feb 26, 2010 |
| 72 | Cats & Dogs: The Revenge of Kitty Galore (Warner Bros.) | $49,110,000 | $13,836,000 | $4,612,000 | Jul 30, 2010 |
| 73 | Edge of Darkness (Warner Bros.) | $48,803,000 | $19,396,000 | $6,465,000 | Jan 29, 2010 |
| 74 | Gulliver's Travels (2010) (Fox) | $48,201,000 | $7,107,000 | $2,369,000 | Dec 25, 2010 |
| 75 | Death at a Funeral (2010) (Sony / Screen Gems) | $48,156,000 | $18,273,000 | $6,091,000 | Apr 16, 2010 |
| 76 | Step Up 3D (Disney) | $47,774,000 | $17,816,000 | $5,939,000 | Aug 06, 2010 |
| 77 | The Last Exorcism (Lionsgate) | $46,235,000 | $22,948,000 | $7,649,000 | Aug 27, 2010 |
| 78 | Legion (Sony / Screen Gems) | $45,259,000 | $19,720,000 | $6,573,000 | Jan 22, 2010 |
| 79 | Burlesque (Sony / Screen Gems) | $44,439,000 | $13,462,000 | $4,487,000 | Nov 24, 2010 |
| 80 | The Crazies (Overture) | $44,082,000 | $18,104,000 | $6,035,000 | Feb 26, 2010 |
| 81 | For Colored Girls (Lionsgate) | $42,512,000 | $21,968,000 | $7,323,000 | Nov 05, 2010 |
| 82 | The Back-up Plan (CBS Films) | $42,242,000 | $13,748,000 | $4,583,000 | Apr 23, 2010 |
| 83 | Vampires Suck (Fox) | $41,308,000 | $13,749,000 | $4,583,000 | Aug 18, 2010 |
| 84 | The American (Focus) | $40,119,000 | $14,848,000 | $4,949,000 | Sep 01, 2010 |
| 85 | Green Zone (Universal) | $39,496,000 | $16,123,000 | $5,374,000 | Mar 12, 2010 |
| 86 | Marmaduke (Fox) | $37,909,000 | $13,070,000 | $4,357,000 | Jun 04, 2010 |
| 87 | Devil (Universal) | $37,860,000 | $13,847,000 | $4,616,000 | Sep 17, 2010 |
| 88 | Hereafter (Warner Bros.) | $36,897,000 | $248,000 | $83,000 | Oct 15, 2010 |
| 89 | When in Rome (Disney) | $36,810,000 | $13,915,000 | $4,638,000 | Jan 29, 2010 |
| 90 | Love and Other Drugs (Fox) | $36,469,000 | $10,974,000 | $3,658,000 | Nov 24, 2010 |
| 91 | She's Out of My League (Paramount) | $35,637,000 | $11,014,000 | $3,671,000 | Mar 12, 2010 |
| 92 | Scott Pilgrim vs. the World (Universal) | $35,520,000 | $11,955,000 | $3,985,000 | Aug 13, 2010 |
| 93 | Charlie St. Cloud (Universal) | $35,112,000 | $13,951,000 | $4,650,000 | Jul 30, 2010 |
| 94 | Morning Glory (2010) (Paramount) | $34,942,000 | $10,370,000 | $3,457,000 | Nov 10, 2010 |
| 95 | How Do You Know (Sony / Columbia) | $34,042,000 | $8,433,000 | $2,811,000 | Dec 17, 2010 |
| 96 | Daybreakers (Lionsgate) | $33,916,000 | $17,066,000 | $5,689,000 | Jan 08, 2010 |
| 97 | Nanny McPhee Returns (Universal) | $32,688,000 | $9,473,000 | $3,158,000 | Aug 20, 2010 |
| 98 | The Switch (2010) (Miramax) | $31,300,000 | $9,506,000 | $3,169,000 | Aug 20, 2010 |
| 99 | Brooklyn's Finest (Overture) | $30,606,000 | $15,042,000 | $5,014,000 | Mar 05, 2010 |
| 100 | Machete (Fox) | $29,964,000 | $12,863,000 | $4,288,000 | Sep 03, 2010 |
| 101 | Ramona and Beezus (Fox) | $29,483,000 | $8,800,000 | $2,933,000 | Jul 23, 2010 |
| 102 | Leap Year (2010) (Universal) | $29,204,000 | $10,369,000 | $3,456,000 | Jan 08, 2010 |
| 103 | You Again (Disney) | $28,960,000 | $9,473,000 | $3,158,000 | Sep 24, 2010 |
| 104 | Alpha and Omega (Lionsgate) | $28,289,000 | $10,261,000 | $3,420,000 | Sep 17, 2010 |
| 105 | Piranha 3D (Weinstein Company) | $28,172,000 | $11,388,000 | $3,796,000 | Aug 20, 2010 |
| 106 | Lottery Ticket (Warner Bros.) | $27,853,000 | $12,002,000 | $4,001,000 | Aug 20, 2010 |
| 107 | The Spy Next Door (Lionsgate) | $27,389,000 | $10,959,000 | $3,653,000 | Jan 15, 2010 |
| 108 | From Paris with Love (Lionsgate) | $27,129,000 | $9,193,000 | $3,064,000 | Feb 05, 2010 |
| 109 | The Losers (Warner Bros.) | $26,581,000 | $10,599,000 | $3,533,000 | Apr 23, 2010 |
| 110 | Faster (2010) (CBS Films) | $26,186,000 | $9,603,000 | $3,201,000 | Nov 24, 2010 |
| 111 | Just Wright (Fox Searchlight) | $24,252,000 | $9,335,000 | $3,112,000 | May 14, 2010 |
| 112 | Skyline (Universal / Rogue) | $24,105,000 | $13,174,000 | $4,391,000 | Nov 12, 2010 |
| 113 | The Next Three Days (Lionsgate) | $23,829,000 | $7,372,000 | $2,457,000 | Nov 19, 2010 |
| 114 | The Kids Are All Right (Focus) | $23,449,000 | $554,000 | $185,000 | Jul 09, 2010 |
| 115 | Our Family Wedding (Fox Searchlight) | $22,817,000 | $8,597,000 | $2,866,000 | Mar 12, 2010 |
| 116 | Country Strong (Sony / Screen Gems) | $22,782,000 | $34,000 | $11,000 | Dec 22, 2010 |
| 117 | Oceans (Disneynature) | $21,884,000 | $6,827,000 | $2,276,000 | Apr 22, 2010 |
| 118 | Remember Me (Summit) | $21,485,000 | $9,114,000 | $3,038,000 | Mar 12, 2010 |
| 119 | 127 Hours (Fox Searchlight) | $20,659,000 | $298,000 | $99,000 | Nov 05, 2010 |
| 120 | Going the Distance (2010) (Warner Bros. / New Line) | $20,061,000 | $7,758,000 | $2,586,000 | Sep 03, 2010 |
| 121 | Furry Vengeance (Summit) | $19,865,000 | $7,468,000 | $2,489,000 | Apr 30, 2010 |
| 122 | Splice (Warner Bros) | $19,166,000 | $8,321,000 | $2,774,000 | Jun 04, 2010 |
| 123 | The Ghost Writer (Summit) | $17,511,000 | $206,000 | $69,000 | Feb 19, 2010 |
| 124 | Youth in Revolt (The Weinstein Company) | $17,212,000 | $7,761,000 | $2,587,000 | Jan 08, 2010 |
| 125 | My Soul to Take (Universal / Rogue) | $16,613,000 | $7,709,000 | $2,570,000 | Oct 08, 2010 |
| 126 | Repo Men (Universal) | $15,543,000 | $6,903,000 | $2,301,000 | Mar 19, 2010 |
| 127 | Case 39 (Paramount Vantage) | $14,943,000 | $6,029,000 | $2,010,000 | Oct 01, 2010 |
| 128 | Extraordinary Measures (CBS Films) | $14,065,000 | $6,775,000 | $2,258,000 | Jan 22, 2010 |
| 129 | Let Me In (Relativity / Overture) | $13,673,000 | $5,800,000 | $1,933,000 | Oct 01, 2010 |
| 130 | Jonah Hex (Warner Bros.) | $11,884,000 | $6,061,000 | $2,020,000 | Jun 18, 2010 |
| 131 | The Girl with the Dragon Tattoo (2009) (Music Box) | $11,375,000 | $378,000 | $126,000 | Mar 19, 2010 |
| 132 | Blue Valentine (2010) (Weinstein Company) | $10,937,000 | $218,000 | $73,000 | Dec 29, 2010 |
| 133 | Fair Game (2010) (Summit) | $10,750,000 | $734,000 | $245,000 | Nov 05, 2010 |
| 134 | Get Low (Sony Pictures Classics) | $10,340,000 | $99,000 | $33,000 | Jul 30, 2010 |
| 135 | MacGruber (Universal / Rogue) | $9,606,000 | $4,555,000 | $1,518,000 | May 21, 2010 |
| 136 | The Girl Who Played With Fire (Music Box) | $8,606,000 | $1,020,000 | $340,000 | Jul 09, 2010 |
| 137 | Cyrus (Fox Searchlight) | $8,400,000 | $205,000 | $68,000 | Jun 18, 2010 |
| 138 | Babies (Focus) | $8,248,000 | $2,435,000 | $812,000 | May 07, 2010 |
| 139 | Conviction (Fox Searchlight) | $7,643,000 | $115,000 | $38,000 | Oct 15, 2010 |
| 140 | City Island (Anchor Bay) | $7,517,000 | $36,000 | $12,000 | Mar 19, 2010 |
| 141 | The Last Station (Sony Pictures Classics) | $7,457,000 | $83,000 | $28,000 | Jan 15, 2010 |
| 142 | Winter's Bone (Roadside Attractions) | $7,359,000 | $96,000 | $32,000 | Jun 11, 2010 |
| 143 | Waiting for 'Superman' (Paramount Vantage) | $7,230,000 | $157,000 | $52,000 | Sep 24, 2010 |
| 144 | The Secret in Their Eyes (2010) (Sony Pictures Classics) | $7,202,000 | $189,000 | $63,000 | Apr 16, 2010 |
| 145 | It's Kind of a Funny Story (Focus) | $7,170,000 | $2,269,000 | $756,000 | Oct 08, 2010 |
| 146 | The Warrior's Way (Relativity Media) | $6,375,000 | $3,435,000 | $1,145,000 | Dec 03, 2010 |
| 147 | The Girl Who Kicked the Hornet's Nest (Music Box) | $5,847,000 | $815,000 | $272,000 | Oct 29, 2010 |
| 148 | Biutiful (Roadside Attractions) | $5,748,000 | $51,000 | $17,000 | Dec 29, 2010 |
| 149 | I Am Love (Magnolia) | $5,640,000 | $137,000 | $46,000 | Jun 18, 2010 |
| 150 | Mao's Last Dancer (Samuel Goldwyn) | $5,428,000 | $225,000 | $75,000 | Aug 20, 2010 |
