| 1 | Toy Story 3 (Disney) | $473,916,000 | $125,965,000 | $41,988,000 | Jun 18, 2010 |
| 2 | Alice in Wonderland (2010) (Disney) | $381,630,000 | $132,582,000 | $44,194,000 | Mar 05, 2010 |
| 3 | Iron Man 2 (Paramount) | $356,436,000 | $146,310,000 | $48,770,000 | May 07, 2010 |
| 4 | The Twilight Saga: Eclipse (Summit) | $343,193,000 | $74,035,000 | $24,678,000 | Jun 30, 2010 |
| 5 | Harry Potter and the Deathly Hallows: Part 1 (Warner Bros.) | $337,999,000 | $142,764,000 | $47,588,000 | Nov 19, 2010 |
| 6 | Inception (Warner Bros.) | $334,108,000 | $71,698,000 | $23,899,000 | Jul 16, 2010 |
| 7 | Despicable Me (Universal) | $287,217,000 | $64,403,000 | $21,468,000 | Jul 09, 2010 |
| 8 | Shrek Forever After (Paramount / DreamWorks) | $272,237,000 | $80,894,000 | $26,965,000 | May 21, 2010 |
| 9 | How to Train Your Dragon (Paramount / DreamWorks) | $248,467,000 | $49,940,000 | $16,647,000 | Mar 26, 2010 |
| 10 | Tangled (Disney) | $229,329,000 | $55,690,000 | $18,563,000 | Nov 24, 2010 |
| 11 | The Karate Kid (2010) (Sony / Columbia) | $201,659,000 | $63,568,000 | $21,189,000 | Jun 11, 2010 |
| 12 | TRON: Legacy (Disney) | $196,487,000 | $50,276,000 | $16,759,000 | Dec 17, 2010 |
| 13 | True Grit (2010) (Paramount) | $195,331,000 | $28,355,000 | $9,452,000 | Dec 22, 2010 |
| 14 | Clash of the Titans (2010) (Warner Bros.) | $186,384,000 | $69,928,000 | $23,309,000 | Apr 02, 2010 |
| 15 | Grown Ups (Sony / Columbia) | $184,998,000 | $46,257,000 | $15,419,000 | Jun 25, 2010 |
| 16 | Little Fockers (Universal) | $169,510,000 | $35,211,000 | $11,737,000 | Dec 22, 2010 |
| 17 | Megamind (Paramount / DreamWorks) | $169,484,000 | $52,549,000 | $17,516,000 | Nov 05, 2010 |
| 18 | The King's Speech (Weinstein Company) | $158,500,000 | $406,000 | $135,000 | Nov 26, 2010 |
| 19 | The Last Airbender (Paramount) | $150,282,000 | $46,049,000 | $15,350,000 | Jul 01, 2010 |
| 20 | Shutter Island (Paramount) | $146,185,000 | $46,891,000 | $15,630,000 | Feb 19, 2010 |
| 21 | The Other Guys (Sony / Columbia) | $136,143,000 | $40,589,000 | $13,530,000 | Aug 06, 2010 |
| 22 | Salt (Sony / Columbia) | $135,106,000 | $41,123,000 | $13,708,000 | Jul 23, 2010 |
| 23 | Jackass 3D (Paramount) | $133,871,000 | $57,501,000 | $19,167,000 | Oct 15, 2010 |
| 24 | Valentine's Day (Warner Bros. / New Line) | $126,170,000 | $64,247,000 | $21,416,000 | Feb 12, 2010 |
| 25 | Black Swan (Fox Searchlight) | $122,137,000 | $1,649,000 | $550,000 | Dec 03, 2010 |
| 26 | Robin Hood (2010) (Universal) | $120,213,000 | $41,182,000 | $13,727,000 | May 14, 2010 |
| 27 | The Chronicles of Narnia: The Voyage of the Dawn Treader (Fox) | $119,205,000 | $27,413,000 | $9,138,000 | Dec 10, 2010 |
| 28 | The Expendables (Lionsgate) | $117,699,000 | $39,769,000 | $13,256,000 | Aug 13, 2010 |
| 29 | Due Date (Warner Bros.) | $114,811,000 | $37,330,000 | $12,443,000 | Nov 05, 2010 |
| 30 | Yogi Bear (Warner Bros.) | $114,476,000 | $18,741,000 | $6,247,000 | Dec 17, 2010 |
| 31 | Date Night (Fox) | $112,724,000 | $28,786,000 | $9,595,000 | Apr 09, 2010 |
| 32 | The Social Network (Sony / Columbia) | $110,727,000 | $25,632,000 | $8,544,000 | Oct 01, 2010 |
| 33 | Sex and the City 2 (Warner Bros. / New Line) | $108,882,000 | $35,403,000 | $11,801,000 | May 27, 2010 |
| 34 | The Book of Eli (Warner Bros.) | $108,297,000 | $37,444,000 | $12,481,000 | Jan 15, 2010 |
| 35 | The Fighter (Paramount) | $106,906,000 | $343,000 | $114,000 | Dec 10, 2010 |
| 36 | The Town (Warner Bros.) | $105,272,000 | $27,188,000 | $9,063,000 | Sep 17, 2010 |
| 37 | Prince of Persia: The Sands of Time (Disney) | $103,643,000 | $34,367,000 | $11,456,000 | May 28, 2010 |
| 38 | Red (2010) (Summit) | $103,210,000 | $24,850,000 | $8,283,000 | Oct 15, 2010 |
| 39 | Percy Jackson and the Olympians: The Lightning Thief (Fox) | $101,362,000 | $35,670,000 | $11,890,000 | Feb 12, 2010 |
| 40 | Paranormal Activity 2 (Paramount) | $96,784,000 | $46,453,000 | $15,484,000 | Oct 22, 2010 |
| 41 | Unstoppable (2010) (Fox) | $93,141,000 | $25,909,000 | $8,636,000 | Nov 12, 2010 |
| 42 | Eat Pray Love (Sony / Columbia) | $92,012,000 | $26,384,000 | $8,795,000 | Aug 13, 2010 |
| 43 | Dear John (Sony / Screen Gems) | $91,373,000 | $34,794,000 | $11,598,000 | Feb 05, 2010 |
| 44 | The A-Team (Fox) | $88,184,000 | $29,313,000 | $9,771,000 | Jun 11, 2010 |
| 45 | Knight and Day (Fox) | $87,271,000 | $22,999,000 | $7,666,000 | Jun 23, 2010 |
| 46 | Dinner for Schmucks (Paramount / DreamWorks) | $83,393,000 | $26,868,000 | $8,956,000 | Jul 30, 2010 |
| 47 | The Tourist (Sony / Columbia) | $77,232,000 | $18,811,000 | $6,270,000 | Dec 10, 2010 |
| 48 | The Bounty Hunter (Sony / Columbia) | $76,581,000 | $23,623,000 | $7,874,000 | Mar 19, 2010 |
| 49 | Diary of a Wimpy Kid (Fox) | $73,089,000 | $25,267,000 | $8,422,000 | Mar 19, 2010 |
| 50 | The Sorcerer's Apprentice (Disney) | $72,115,000 | $20,121,000 | $6,707,000 | Jul 14, 2010 |
| 51 | A Nightmare on Elm Street (2010) (Warner Bros. / New Line) | $72,029,000 | $37,572,000 | $12,524,000 | Apr 30, 2010 |
| 52 | The Last Song (Disney) | $71,886,000 | $18,280,000 | $6,093,000 | Mar 31, 2010 |
| 53 | The Wolfman (Universal) | $70,778,000 | $35,948,000 | $11,983,000 | Feb 12, 2010 |
| 54 | Get Him to the Greek (Universal) | $69,630,000 | $20,065,000 | $6,688,000 | Jun 04, 2010 |
| 55 | Resident Evil: Afterlife (Sony / Screen Gems) | $68,664,000 | $30,433,000 | $10,144,000 | Sep 10, 2010 |
| 56 | Tyler Perry's Why Did I Get Married Too? (Lionsgate) | $68,627,000 | $33,447,000 | $11,149,000 | Apr 02, 2010 |
| 57 | The Tooth Fairy (Fox) | $68,543,000 | $15,999,000 | $5,333,000 | Jan 22, 2010 |
| 58 | Secretariat (Disney) | $68,190,000 | $14,497,000 | $4,832,000 | Oct 08, 2010 |
| 59 | Easy A (Sony / Screen Gems) | $66,692,000 | $20,251,000 | $6,750,000 | Sep 17, 2010 |
| 60 | Takers (Sony / Screen Gems) | $65,942,000 | $23,424,000 | $7,808,000 | Aug 27, 2010 |
| 61 | Legend of the Guardians: The Owls of Ga'Hoole (Warner Bros.) | $63,579,000 | $18,399,000 | $6,133,000 | Sep 24, 2010 |
| 62 | Life As We Know It (Warner Bros.) | $60,951,000 | $16,566,000 | $5,522,000 | Oct 08, 2010 |
| 63 | Letters to Juliet (Summit) | $60,561,000 | $15,463,000 | $5,154,000 | May 14, 2010 |
| 64 | Wall Street: Money Never Sleeps (Fox) | $59,923,000 | $21,710,000 | $7,237,000 | Sep 24, 2010 |
| 65 | Predators (Fox) | $59,382,000 | $28,276,000 | $9,425,000 | Jul 09, 2010 |
| 66 | Hubble 3D (Warner Bros. / IMAX) | $59,241,000 | $469,000 | $156,000 | Mar 19, 2010 |
| 67 | Hot Tub Time Machine (MGM) | $57,426,000 | $16,011,000 | $5,337,000 | Mar 26, 2010 |
| 68 | Kick-Ass (Lionsgate) | $54,895,000 | $22,643,000 | $7,548,000 | Apr 16, 2010 |
| 69 | Killers (2010) (Lionsgate) | $53,740,000 | $18,085,000 | $6,028,000 | Jun 04, 2010 |
| 70 | Saw 3D (Lionsgate) | $52,199,000 | $27,670,000 | $9,223,000 | Oct 29, 2010 |
| 71 | Cop Out (Warner Bros.) | $51,245,000 | $20,796,000 | $6,932,000 | Feb 26, 2010 |
| 72 | Cats & Dogs: The Revenge of Kitty Galore (Warner Bros.) | $49,773,000 | $14,022,000 | $4,674,000 | Jul 30, 2010 |
| 73 | Edge of Darkness (Warner Bros.) | $49,462,000 | $19,658,000 | $6,553,000 | Jan 29, 2010 |
| 74 | Gulliver's Travels (2010) (Fox) | $48,852,000 | $7,203,000 | $2,401,000 | Dec 25, 2010 |
| 75 | Death at a Funeral (2010) (Sony / Screen Gems) | $48,806,000 | $18,520,000 | $6,173,000 | Apr 16, 2010 |
| 76 | Step Up 3D (Disney) | $48,419,000 | $18,057,000 | $6,019,000 | Aug 06, 2010 |
| 77 | The Last Exorcism (Lionsgate) | $46,859,000 | $23,258,000 | $7,753,000 | Aug 27, 2010 |
| 78 | Legion (Sony / Screen Gems) | $45,870,000 | $19,986,000 | $6,662,000 | Jan 22, 2010 |
| 79 | Burlesque (Sony / Screen Gems) | $45,039,000 | $13,644,000 | $4,548,000 | Nov 24, 2010 |
| 80 | The Crazies (Overture) | $44,677,000 | $18,348,000 | $6,116,000 | Feb 26, 2010 |
| 81 | For Colored Girls (Lionsgate) | $43,085,000 | $22,265,000 | $7,422,000 | Nov 05, 2010 |
| 82 | The Back-up Plan (CBS Films) | $42,812,000 | $13,934,000 | $4,645,000 | Apr 23, 2010 |
| 83 | Vampires Suck (Fox) | $41,866,000 | $13,935,000 | $4,645,000 | Aug 18, 2010 |
| 84 | The American (Focus) | $40,661,000 | $15,048,000 | $5,016,000 | Sep 01, 2010 |
| 85 | Green Zone (Universal) | $40,030,000 | $16,341,000 | $5,447,000 | Mar 12, 2010 |
| 86 | Marmaduke (Fox) | $38,421,000 | $13,246,000 | $4,415,000 | Jun 04, 2010 |
| 87 | Devil (Universal) | $38,371,000 | $14,034,000 | $4,678,000 | Sep 17, 2010 |
| 88 | Hereafter (Warner Bros.) | $37,395,000 | $252,000 | $84,000 | Oct 15, 2010 |
| 89 | When in Rome (Disney) | $37,306,000 | $14,103,000 | $4,701,000 | Jan 29, 2010 |
| 90 | Love and Other Drugs (Fox) | $36,962,000 | $11,122,000 | $3,707,000 | Nov 24, 2010 |
| 91 | She's Out of My League (Paramount) | $36,118,000 | $11,163,000 | $3,721,000 | Mar 12, 2010 |
| 92 | Scott Pilgrim vs. the World (Universal) | $35,999,000 | $12,116,000 | $4,039,000 | Aug 13, 2010 |
| 93 | Charlie St. Cloud (Universal) | $35,586,000 | $14,139,000 | $4,713,000 | Jul 30, 2010 |
| 94 | Morning Glory (2010) (Paramount) | $35,414,000 | $10,510,000 | $3,503,000 | Nov 10, 2010 |
| 95 | How Do You Know (Sony / Columbia) | $34,501,000 | $8,547,000 | $2,849,000 | Dec 17, 2010 |
| 96 | Daybreakers (Lionsgate) | $34,374,000 | $17,297,000 | $5,766,000 | Jan 08, 2010 |
| 97 | Nanny McPhee Returns (Universal) | $33,129,000 | $9,601,000 | $3,200,000 | Aug 20, 2010 |
| 98 | The Switch (2010) (Miramax) | $31,723,000 | $9,634,000 | $3,211,000 | Aug 20, 2010 |
| 99 | Brooklyn's Finest (Overture) | $31,020,000 | $15,245,000 | $5,082,000 | Mar 05, 2010 |
| 100 | Machete (Fox) | $30,369,000 | $13,037,000 | $4,346,000 | Sep 03, 2010 |
| 101 | Ramona and Beezus (Fox) | $29,881,000 | $8,919,000 | $2,973,000 | Jul 23, 2010 |
| 102 | Leap Year (2010) (Universal) | $29,598,000 | $10,509,000 | $3,503,000 | Jan 08, 2010 |
| 103 | You Again (Disney) | $29,351,000 | $9,601,000 | $3,200,000 | Sep 24, 2010 |
| 104 | Alpha and Omega (Lionsgate) | $28,671,000 | $10,400,000 | $3,467,000 | Sep 17, 2010 |
| 105 | Piranha 3D (Weinstein Company) | $28,552,000 | $11,542,000 | $3,847,000 | Aug 20, 2010 |
| 106 | Lottery Ticket (Warner Bros.) | $28,229,000 | $12,164,000 | $4,055,000 | Aug 20, 2010 |
| 107 | The Spy Next Door (Lionsgate) | $27,758,000 | $11,107,000 | $3,702,000 | Jan 15, 2010 |
| 108 | From Paris with Love (Lionsgate) | $27,495,000 | $9,317,000 | $3,106,000 | Feb 05, 2010 |
| 109 | The Losers (Warner Bros.) | $26,940,000 | $10,742,000 | $3,581,000 | Apr 23, 2010 |
| 110 | Faster (2010) (CBS Films) | $26,539,000 | $9,733,000 | $3,244,000 | Nov 24, 2010 |
| 111 | Just Wright (Fox Searchlight) | $24,579,000 | $9,461,000 | $3,154,000 | May 14, 2010 |
| 112 | Skyline (Universal / Rogue) | $24,430,000 | $13,352,000 | $4,451,000 | Nov 12, 2010 |
| 113 | The Next Three Days (Lionsgate) | $24,151,000 | $7,472,000 | $2,491,000 | Nov 19, 2010 |
| 114 | The Kids Are All Right (Focus) | $23,766,000 | $562,000 | $187,000 | Jul 09, 2010 |
| 115 | Our Family Wedding (Fox Searchlight) | $23,125,000 | $8,713,000 | $2,904,000 | Mar 12, 2010 |
| 116 | Country Strong (Sony / Screen Gems) | $23,089,000 | $35,000 | $12,000 | Dec 22, 2010 |
| 117 | Oceans (Disneynature) | $22,179,000 | $6,919,000 | $2,306,000 | Apr 22, 2010 |
| 118 | Remember Me (Summit) | $21,775,000 | $9,237,000 | $3,079,000 | Mar 12, 2010 |
| 119 | 127 Hours (Fox Searchlight) | $20,938,000 | $302,000 | $101,000 | Nov 05, 2010 |
| 120 | Going the Distance (2010) (Warner Bros. / New Line) | $20,332,000 | $7,862,000 | $2,621,000 | Sep 03, 2010 |
| 121 | Furry Vengeance (Summit) | $20,133,000 | $7,568,000 | $2,523,000 | Apr 30, 2010 |
| 122 | Splice (Warner Bros) | $19,425,000 | $8,433,000 | $2,811,000 | Jun 04, 2010 |
| 123 | The Ghost Writer (Summit) | $17,748,000 | $209,000 | $70,000 | Feb 19, 2010 |
| 124 | Youth in Revolt (The Weinstein Company) | $17,444,000 | $7,866,000 | $2,622,000 | Jan 08, 2010 |
| 125 | My Soul to Take (Universal / Rogue) | $16,837,000 | $7,813,000 | $2,604,000 | Oct 08, 2010 |
| 126 | Repo Men (Universal) | $15,753,000 | $6,996,000 | $2,332,000 | Mar 19, 2010 |
| 127 | Case 39 (Paramount Vantage) | $15,144,000 | $6,110,000 | $2,037,000 | Oct 01, 2010 |
| 128 | Extraordinary Measures (CBS Films) | $14,255,000 | $6,866,000 | $2,289,000 | Jan 22, 2010 |
| 129 | Let Me In (Relativity / Overture) | $13,858,000 | $5,878,000 | $1,959,000 | Oct 01, 2010 |
| 130 | Jonah Hex (Warner Bros.) | $12,044,000 | $6,143,000 | $2,048,000 | Jun 18, 2010 |
| 131 | The Girl with the Dragon Tattoo (2009) (Music Box) | $11,528,000 | $383,000 | $128,000 | Mar 19, 2010 |
| 132 | Blue Valentine (2010) (Weinstein Company) | $11,084,000 | $221,000 | $74,000 | Dec 29, 2010 |
| 133 | Fair Game (2010) (Summit) | $10,895,000 | $744,000 | $248,000 | Nov 05, 2010 |
| 134 | Get Low (Sony Pictures Classics) | $10,480,000 | $101,000 | $34,000 | Jul 30, 2010 |
| 135 | MacGruber (Universal / Rogue) | $9,736,000 | $4,617,000 | $1,539,000 | May 21, 2010 |
| 136 | The Girl Who Played With Fire (Music Box) | $8,723,000 | $1,033,000 | $344,000 | Jul 09, 2010 |
| 137 | Cyrus (Fox Searchlight) | $8,514,000 | $208,000 | $69,000 | Jun 18, 2010 |
| 138 | Babies (Focus) | $8,359,000 | $2,468,000 | $823,000 | May 07, 2010 |
| 139 | Conviction (Fox Searchlight) | $7,746,000 | $117,000 | $39,000 | Oct 15, 2010 |
| 140 | City Island (Anchor Bay) | $7,618,000 | $37,000 | $12,000 | Mar 19, 2010 |
| 141 | The Last Station (Sony Pictures Classics) | $7,557,000 | $84,000 | $28,000 | Jan 15, 2010 |
| 142 | Winter's Bone (Roadside Attractions) | $7,459,000 | $97,000 | $32,000 | Jun 11, 2010 |
| 143 | Waiting for 'Superman' (Paramount Vantage) | $7,328,000 | $159,000 | $53,000 | Sep 24, 2010 |
| 144 | The Secret in Their Eyes (2010) (Sony Pictures Classics) | $7,299,000 | $192,000 | $64,000 | Apr 16, 2010 |
| 145 | It's Kind of a Funny Story (Focus) | $7,267,000 | $2,299,000 | $766,000 | Oct 08, 2010 |
| 146 | The Warrior's Way (Relativity Media) | $6,461,000 | $3,481,000 | $1,160,000 | Dec 03, 2010 |
| 147 | The Girl Who Kicked the Hornet's Nest (Music Box) | $5,926,000 | $826,000 | $275,000 | Oct 29, 2010 |
| 148 | Biutiful (Roadside Attractions) | $5,825,000 | $52,000 | $17,000 | Dec 29, 2010 |
| 149 | I Am Love (Magnolia) | $5,716,000 | $139,000 | $46,000 | Jun 18, 2010 |
| 150 | Mao's Last Dancer (Samuel Goldwyn) | $5,502,000 | $228,000 | $76,000 | Aug 20, 2010 |
